Acne Conglobata Associated with Hidradenitis Suppurativa, Disorders of Follicular Occlusion (Case Report)

K. Pecova

Journal & Issue Details

Journal Details

Format: Journal
First Published: 03 Jun 2011
Publication timeframe: 3 times per year
Languages: English

The author is presenting the case of a 23-year-old female patient with a severe form of acne conglobata, with the first symptoms of the disease occurring as far back as the prepubertal age. In the past year the disease has combined with hidradenitis suppurativa (to be referred to henceforth as “HS”), Hurley stage I, in the axillae and both sides of the inguinal region, with a family history of acne conglobata (both her mother and brother were affected). Further examinations ruled out inflammatory bowel disease because of a lack of further associated symptoms, except for sideropenic anaemia (lesser form) and lower serum values of vitamin D. Up until now the disease has been resistant to treatment, including the long-term treatment of methylprednisolone in combination with isotretinoid as well as dapsone and antibiotics.

Keywords

acne conglobata
hidradenitis suppurativa
treatment

References

1. Margesson, L.J., Danby, F.W.: Hidradenitis suppurativa. Best Pract Research Obstet & Gynecol 2014; 28: 1013 - 1027.Search in Google Scholar

2. Kahn, M.F., Chamot, A.M.: SAPHO syndrome. Rheum Dis Clin North Am 1992; 18(1): 225 - 246.Search in Google Scholar

3. Van der Zee, H.H., van der Woude, C.J., Florencia, E.F. et al.: Hidradenitis suppurativa and inflammatory bowel disease: are they associated? Results of a pilot study. Br J Dermatol 2010; 162(1): 195 - 197.Search in Google Scholar

4. Alikhan, A., Lynch, P.J., Eisen, D.B.: Hidradenitis suppurativa : a comprehensive review. J Am Acad Dermatol 2009; 60(4): 539 - 561.Search in Google Scholar

5. Han, G.: Biologics in dermatology beyond psoriasis. Cutis 2014; 93(5):E21 - E27.Search in Google Scholar

6. Danby, F.W., Jemec, G.B., Marsch, W. et al.: Preliminary findings suggest hidradenitis suppurativa may be due to defective follicular support. Br J Dermatol 2013;168(5): 1034 - 1039.Search in Google Scholar

7. Gniadecki, R., Jemec, G.B.: Lipid raft-enriched stem cell-like keratinocytes in the epidermis, hair follicles and sinus tracts in hidradenitis suppurativa. Exp Dermatol 2004;13(6): 361 - 363.Search in Google Scholar

8. Melnik, B.C., Zouboulis, C.C.: Potentional role of FoxO1 and mTORC1 in the pathogenesis of western dietinduced acne. Exp Dermatol 2013;22(5): 311 - 315.Search in Google Scholar

9. von der Werth, J.M., Williams, H.C., Raeburn, J.A.: The clinical genetics of hidradenitis suppurativa revisited. Br J Dermatol 2000;142: 947 - 953Search in Google Scholar