1. bookVolume 64 (2017): Issue 2 (November 2017)
Journal Details
License
Format
Journal
eISSN
2453-6725
First Published
25 Nov 2011
Publication timeframe
2 times per year
Languages
English
access type Open Access

Partial molecular volumes of cholesterol and phosphatidylcholine in mixed bilayers

Published Online: 30 Nov 2017
Volume & Issue: Volume 64 (2017) - Issue 2 (November 2017)
Page range: 1 - 3
Received: 22 Jun 2016
Accepted: 19 Jul 2016
Journal Details
License
Format
Journal
eISSN
2453-6725
First Published
25 Nov 2011
Publication timeframe
2 times per year
Languages
English
Abstract

Dispersion of multilamellar liposomes of dimyristoylphosphatidylcholine (DMPC) and cholesterol (CHOL) were studied by vibrational densitometer for the CHOL mole fractions X = 0−0.54 in the temperature range 18−50 °C, both below and above the main phase transition. DMPC-CHOL bilayers served as a simple model for lipidic part of biological membrane. Volumetric parameters are essential not only to evaluate the data obtained by scattering and diffraction methods on model membranes but can provide valuable information about molecular packing in bilayers and the phase behaviour of lipid-CHOL mixtures. In this paper, preliminary results regarding the changes in the specific volume of lipid bilayer with increasing temperature and CHOL content are presented. Different values of apparent molecular volume of CHOL for different CHOL mole fraction pointed out the non-ideal mixing of DMPC and CHOL.

Keywords

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