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  1. bookVolume 49 (2015): Issue 4 (December 2015)
Radiology and Oncology's Cover Image
Radiology and Oncology
Journal Details
License
Format
Journal
First Published
30 Apr 2007
Publication timeframe
4 times per year
Languages
English
access type Open Access

Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CT

Sebastijan Rep
Luka Lezaic
Tomaz Kocjan
Marija Pfeifer
Mojca Jensterle Sever
Urban Simoncic
Petra Tomse
Marko Hocevar
Published Online: 27 Nov 2015
Page range: 327 - 333
Received: 06 Jan 2015
Accepted: 31 Mar 2015
Journal Details
License
Format
Journal
First Published
30 Apr 2007
Publication timeframe
4 times per year
Languages
English
Abstract

Background. Parathyroid adenomas, the most common cause of primary hyperparathyroidism, are benign tumours which autonomously produce and secrete parathyroid hormone. [18F]-fluorocholine (FCH), PET marker of cellular proliferation, was recently demonstrated to accumulate in lesions representing enlarged parathyroid tissue; however, the optimal time to perform FCH PET/CT after FCH administration is not known. The aim of this study was to determine the optimal scan time of FCH PET/CT in patients with primary hyperparathyroidism.

Patients and methods. 43 patients with primary hyperparathyroidism were enrolled in this study. A triple-phase PET/CT imaging was performed five minutes, one and two hours after the administration of FCH. Regions of interest (ROI) were placed in lesions representing enlarged parathyroid tissue and thyroid tissue. Standardized uptake value (SUVmean), retention index and lesion contrast for parathyroid and thyroid tissue were calculated.

Results. Accumulation of FCH was higher in lesions representing enlarged parathyroid tissue in comparison to the thyroid tissue with significantly higher SUVmean in the second and in the third phase (p < 0.0001). Average retention index decreased significantly between the first and the second phase and increased significantly between the second and the third phase in lesions representing enlarged parathyroid tissue and decreased significantly over all three phases in thyroid tissue (p< 0.0001). The lesion contrast of lesions representing enlarged parathyroid tissue and thyroid tissue was significantly better in the second and the third phase compared to the first phase (p < 0.05).

Conclusions. According to the results the optimal scan time of FCH PET/CT for localization of lesions representing enlarged parathyroid tissue is one hour after administration of the FCH.

Keywords

  • [F]-fluorocholine PET/CT
  • lesions representing enlarged parathyroid tissue
  • triple-phase
  • standardized up-take value
  • retention index
  • lesion contrast

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