1. bookVolume 26 (2018): Issue 2 (December 2018)
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08 Aug 2013
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access type Open Access

Synthesis and Evaluation of Cytotoxic Activity on Mcf-7 Cell Line of Some Diesters Derived from 5-(Hydroxybenzylidene)Thiazolidine-2,4-Diones

Published Online: 03 Jan 2019
Page range: 233 - 248
Journal Details
License
Format
Journal
First Published
08 Aug 2013
Publication timeframe
2 times per year
Languages
English

Knoevenagel condensation of thiazolidine-2,4-dione, which were prepared from chloroacetic acid and thioure by 1,3 dipolar cycloaddition reaction, with 2-hydroxybenzaldehyde, 5-bromo-2-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde and 4-hydoxy-3-methoxybezaldehyde gave five corresponding 5-(hydroxybenzylidene)thiazolidine-2,4-dione compounds. The reaction of 5-(hydroxybenzylidene)thiazolidine-2,4-diones and ethyl chlorofomate or ethyl chloroacetate occurred at both NH and OH centers and gave ten corresponding diesters. The structures of the diesters were confirmed by IR, MS, 1H and 13C-NMR spectral data. However, in test for cytotoxic activity against MCF-7 cells, none of the diester compounds exhibited significant activity.

Keywords

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