1. bookVolume 72 (2022): Issue 2 (June 2022)
Journal Details
License
Format
Journal
eISSN
1846-9558
First Published
28 Feb 2007
Publication timeframe
4 times per year
Languages
English
access type Open Access

Chemical composition, antioxidant, antimicrobial and antiviral activities of the leaf extracts of Syzygium myrtifolium

Published Online: 30 Dec 2021
Page range: 317 - 328
Accepted: 29 Mar 2021
Journal Details
License
Format
Journal
eISSN
1846-9558
First Published
28 Feb 2007
Publication timeframe
4 times per year
Languages
English
Abstract

This study was conducted to evaluate the chemical composition and biological activities of the leaf extracts of Syzygium myrtifolium Walp. (Myrtaceae). The results indicate that the leaf extracts of S. myrtifolium contain various classes of phytochemicals (alkaloids, anthraquinones, flavonoids, phenolics, saponins, tannins and triterpenoids) and possess antioxidant, antibacterial, antifungal and antiviral activities. Ethyl acetate, ethanol, methanol, and water extracts exhibited significantly higher (p < 0.05) oxygen radical absorbance capacity and ferric-reducing antioxidant power than the hexane and chloroform extracts. However, all extracts exhibited stronger inhibitory activity against four tested species of yeasts (minimal inhibitory concentration: 0.02–0.31 mg mL–1) than against six tested species of bacteria (minimal inhibitory concentration: 0.16–1.25 mg mL–1). The ethanolic extract offered the highest protection of Vero cells (viability > 70 %) from the cytopathic effect caused by the Chikungunya virus while the ethyl acetate extract showed significant replication inhibitory activity against the virus (p < 0.001) using the replicon-enhanced green fluorescent protein reporter system.

Keywords

C. M. Boo, O. Kartini and C. L. Ou-Yang, 1001 Garden Plants in Singapore, 2nd ed., National Parks Board, Singapore 2003.Search in Google Scholar

A. H. Memon, Z. Ismail, A. F. A. Aisha, F. S. R. Al-Suede, M. S. Ridzuan Hamil, S. Hashim, M. A. Saeed, M. Laghari and A. M. Abdul Majid, Isolation, characterization, crystal structure elucidation, and anticancer study of dimethyl cardamonin, isolated from Syzygium campanulatum Korth, Evid. Based Complement. Alternat. Med. 2014 (2014) Article ID 470179; https://doi.org/10.1155/2014/47017910.1155/2014/470179422881625530783Search in Google Scholar

A. F. A. Aisha, Z. Ismail, K. M. Abu-Salah, J. M. Siddiqui, G. Ghahar and A. M. S. Abdul Majid, Syzygium campanulatum Korth methanolic extract inhibits angiogenesis and tumor growth in nude mice, BMC Complement. Altern. Med. 13 (2013) Article ID 168; https://doi.org/10.1186/1472-6882-13-16810.1186/1472-6882-13-168371707923842450Search in Google Scholar

A. F. A. Aisha, K. M. Abu Salah, Y. Darwis and A. M. S. Abdul Majid, Screening of antiangiogenic activity of some tropical plants by rat aorta ring assay, Int. J. Pharmacol. 5 (2009) 370–376; https://doi.org/10.3923/ijp.2009.370.37610.3923/ijp.2009.370.376Search in Google Scholar

I. I. Zakaria, N. H. Salin, A. Amanah, S. Othman, F. Khairuddin, M. H. Khawory, R. A. Wahab, M. R. A. Rahaman, P. P. Chern, N. A. Johari and H. Wahab, Potential antiviral compounds from Malaysian Plant Natural Product Repository and Database (MyNature50000) for DENV2, Biotechnol. Biotechnol. Equip. 33 (2019) 379–389; https://doi.org/10.1080/13102818.2019.157818410.1080/13102818.2019.1578184Search in Google Scholar

A. H. Memon, Z. Ismail, F. S. Al-Suede, A. F. Aisha, M. S. Hamil, M. A. Saeed, M. Laghari and A. M. Majid, Isolation, characterization, crystal structure elucidation of two flavanones and simultaneous RP-HPLC determination of five major compounds from Syzygium campanulatum Korth, Molecules 20 (2015) 14212–14233; https://doi.org/10.3390/molecules20081421210.3390/molecules200814212633187626248073Search in Google Scholar

G. Pizzino, N. Irrera, M. Cucinotta, G. Pallio, F. Mannino, V. Arcoraci, F. Squadrito, D. Altavilla and A. Bitto, Oxidative stress: Harms and benefits for human health, Oxid. Med. Cell. Longev. 2017 (2017) Article ID 8416763 (13 pages); https://doi.org/10.1155/2017/841676310.1155/2017/8416763555154128819546Search in Google Scholar

World Health Organization, WHO Methods and Data Sources for Global Burden of Disease Estimates 2000-2016; https://www.who.int/healthinfo/global_burden_disease/GlobalDALY_method_2000_2016.pdf?ua=1; last access date February 29, 2020Search in Google Scholar

F. Bongomin, S. Gago, R. O. Oladele and D. W. Denning, Global and multi-national prevalence of fungal diseases-estimate precision, J. Fungi (Basel) 3 (2017) Article ID 57; https://doi.org/10.3390/jof304005710.3390/jof3040057575315929371573Search in Google Scholar

C. R. Morrison, K. S. Plante and M. T. Heise, Chikungunya virus: Current perspectives on a reemerging virus, Microbiol. Spectrum 4 (2016) Article ID EI10-0017-2016 (14 pages); https://doi.org/10.1128/microbiolspec.EI10-0017-201610.1128/microbiolspec.EI10-0017-2016648830127337473Search in Google Scholar

J. B. Harborne, Phytochemical Methods. A Guide to Modern Techniques of Plant Analysis, 3rd ed., Chapman and Hall, London 1998.Search in Google Scholar

T. J. Herald, P. Gadgil and M. Tilley, High-throughput micro plate assays for screening flavonoid content and DPPH-scavenging activity in sorghum bran and flour, J. Sci. Food Agric. 92 (2012) 2326–2331; https://doi.org/10.1002/jsfa.563310.1002/jsfa.563322419130Search in Google Scholar

K. Pavithra and S. Vadivukkarasi, Evaluation of free radical scavenging activity of various extracts of leaves from Kedrostis foetidissima (Jacq.) Cogn., Food Sci. Hum. Wellness 4 (2015) 42–46; https://doi.org/10.1016/j.fshw.2015.02.00110.1016/j.fshw.2015.02.001Search in Google Scholar

H. Yang, Y. Dong, H. Du, H. Shi, Y. Peng and X. Li, Antioxidant compounds from propolis collected in Anhui, China, Molecules 16 (2011) 3444–3455; https://doi.org/10.3390/molecules1604344410.3390/molecules16043444626063421512452Search in Google Scholar

Y. W. Heng, J. J. Ban, K. S. Khoo and N. W. Sit, Biological activities and phytochemical content of the rhizome hairs of Cibotium barometz (Cibotiaceae), Ind. Crops Prod. 153 (2020) Article ID 112612; https://doi.org/10.1016/j.indcrop.2020.11261210.1016/j.indcrop.2020.112612Search in Google Scholar

Y. S. Chan, K. S. Khoo and N. W. Sit, Investigation of twenty selected medicinal plants from Malaysia for anti-Chikungunya virus activity, Int. Microbiol. 19 (2016) 175–182; https://doi.org/10.2436/20.1501.01.275Search in Google Scholar

N. W. Sit, Y. S. Chan, S. C. Lai, L. N. Lim, G. T. Looi, P. L. Tay, Y. T. Tee, Y. Y. Woon, K. S. Khoo and H. C. Ong, In vitro antidermatophytic activity and cytotoxicity of extracts derived from medicinal plants and marine algae, J. Mycol. Med. 28 (2018) 561–567; https://doi.org/10.1016/j.mycmed.2018.07.00110.1016/j.mycmed.2018.07.00130060991Search in Google Scholar

G. Repetto, A. del Peso and J. L. Zurita, Neutral red uptake assay for the estimation of cell viability/cytotoxicity, Nat. Protoc. 3 (2008) 1125–1131; https://doi.org/10.1038/nprot.2008.7510.1038/nprot.2008.7518600217Search in Google Scholar

M.-K. Liu, J.-J. Lin, C.-Y. Chen, S.-C. Kuo, Y.-M. Wang, H.-L. Chan and T. Y. Wu, Topoisomerase II inhibitors can enhance baculovirus-mediated gene expression in mammalian cells through the DNA damage response, Int. J. Mol. Sci. 17 (2016) Article ID 931 (15 pages); https://doi.org/10.3390/ijms1706093110.3390/ijms17060931492646427314325Search in Google Scholar

M. Insanu, Z. M. Ramadhania, E. N. Halim, R. Hartati and K. R. Wirasutisna, Isolation of 5,7-dihydroxy, 6,8-dimethyl flavanone from Syzygium aqueum with its antioxidant and xanthine oxidase inhibitor activities, Pharmacogn. Res. 10 (2018) 60–63; https://doi.org/10.4103/pr.pr_59_17Search in Google Scholar

L. Woźniak, S. Skąpska and K. Marszalek, Ursolic acid – a pentacyclic triterpenoid with a wide spectrum of pharmacological activities, Molecules 20 (2015) 20614–20641; https://doi.org/10.3390/molecules20111972110.3390/molecules201119721633238726610440Search in Google Scholar

J. L. Ríos and S. Máñez, New pharmacological opportunities for betulinic acid, Planta Med. 84 (2018) 8–19; https://doi.org/10.1055/s-0043-12347210.1055/s-0043-12347229202513Search in Google Scholar

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