1. bookVolume 13 (2020): Issue 2 (October 2020)
Journal Details
License
Format
Journal
First Published
10 Dec 2012
Publication timeframe
2 times per year
Languages
English
access type Open Access

Impact of packing density on primary drying rate

Published Online: 18 Nov 2020
Page range: 30 - 37
Journal Details
License
Format
Journal
First Published
10 Dec 2012
Publication timeframe
2 times per year
Languages
English
Abstract

This work aimed to determine the effect of packing density on the sublimation rate in a laboratory freeze dryer. Total amount of sublimed water was determined by gravimetric method while a total of seven experiments were performed under the same conditions (pressure, temperature, and drying time), at different configuration of the vials. The experiments confirmed that the higher the packing density, the lower the drying rate, and vice versa, the lower the packing density, the higher the drying rate. The effect of vials packing density was confirmed by experiments using a plastic rack, while the vials were separated and thus the packing density was lower. In this case, the drying rate was more homogeneous, which contributes to the higher quality of the final product.

Keywords

Assegehegn G, Fuente EB, Franco JM, Gallegos C (2018) The importance of understanding the freezing step and its impact on freeze-drying process performance. Journal of Pharmaceutical Science. 108: 1378—1395.Search in Google Scholar

Daller S, Friess W, Schroeder R (2020) Energy transfer in vials nested in a rack system during lyophilization. Pharmaceutics 12.Search in Google Scholar

Hibler S, Wagner Ch, Gieseler F (2012) Vial freeze-drying, Part 1: New insights into heat transfer characteristics of tubing and molded vials. Journal of Pharmaceutical Sciences. 101: 1189—1201.Search in Google Scholar

Pikal MJ, Roy ML, Shah S (1983) Mass and heat transfer in vial freeze-drying of pharmaceuticals: Role of the vial. Journal of Pharmaceutical Sciences. 73: 1224—1237.Search in Google Scholar

Pisano R, Fissore D, Barresi AA (2011) Heat transfer in Freeze-Drying Apparatus. Developments in Heat Transfer.Search in Google Scholar

Placek J (2001) Heat transfer limitations, their reduction and control. Proceed. Freeze-Drying Pharm Biologic, Breckenridge.Search in Google Scholar

Rambhatla S, Pikal MJ (2003) Heat and mass transfer scale-up issues during freeze-drying, I: Atypical radiation and the edge vial effect. AAPS PharmSciTech 4(2).Search in Google Scholar

Tang X, Pikal MJ (2004) Design of freeze-drying processes for pharmaceuticals: practical advice. Pharm. Res. 21: 191—200.Search in Google Scholar

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