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First Published
25 Nov 2011
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4 times per year
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English
access type Open Access

Relationship between polymorphism within Peptidoglycan Recognition Protein 1 gene (PGLYRP1) and somatic cell counts in milk of Holstein cows

Published Online: 17 Sep 2021
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Journal Details
License
Format
Journal
First Published
25 Nov 2011
Publication timeframe
4 times per year
Languages
English
Abstract

Bovine peptidoglycan recognition protein 1 (PGLYRP1) is an important receptor that binds to murein peptidoglycans (PGN) of Gram-positive and Gram-negative bacteria and is, therefore, involved in innate immunity. The SNP T>C rs68268284 located in the 1st exon of the PGLYRP1 gene was identified by the PCR-RFLP method in a population of 319 Holstein cows. Somatic cell count (SCC) was measured 7–10 times in each of three completed lactations to investigate whether the PGLYRP1 polymorphism is associated with SCC. Using the GLM model, it was found that cows with the TT genotype showed significantly lower somatic cell counts than those with the CC genotype during the first lactation (P = 0.023). Moreover, during lactations 1–2 and 1–3, cows with the TT genotype reveal significantly lower SCC than CT heterozygotes, at P = 0.025 and P = 0.006, respectively. Computer-aided analysis showed that rs68268284 polymorphism could modify the PGLYRP1 functions because the mutated residue is located in a domain that is important for the binding of other molecules.

Keywords

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