1. bookVolume 23 (2022): Issue 1 (March 2022)
Journal Details
License
Format
Journal
eISSN
2353-8627
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
access type Open Access

Consequences of the rs6265 (Val66Met) polymorphism in the BDNF gene in selected mental disorders and sport

Published Online: 11 Jul 2022
Volume & Issue: Volume 23 (2022) - Issue 1 (March 2022)
Page range: 24 - 33
Received: 21 Mar 2022
Accepted: 31 May 2022
Journal Details
License
Format
Journal
eISSN
2353-8627
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
Abstract

Introduction: Brain-derived neurotrophic factor (BDNF) is a polypeptide of 247 amino acid residues and is widely distributed throughout the central nervous system of the CNS. It plays an important role in the survival, differentiation, growth, and development of neurons in the central nervous system. The human BDNF gene is located on chromosome 11 in the p13-14 region and covers approximately 70 kb. The gene has a complex structure as it consists of 11 exons (I-IX, plus Vh and VIIIh) and nine functional promoters. BDNF expression in the brain is relatively low but it is found in most major regions of the brain.

Material and methods: The gene encoding the brain-derived neurotrophic factor BDNF has many polymorphisms, but one of them mainly attracts the attention of researchers. This is a common, non-conservative polymorphism - rs6265 - a single nucleotide SNP polymorphism that results in an amino acid change – valine (Val) to methionine (Met) - at codon 66.

Results: Polymorphism rs6265 is associated with many neuropsychiatric disorders, including depression or a higher risk of addiction, but it also determines other features, such as e.g. sports performance. Few studies are investigating the relationship between rs6265 polymorphism and predisposition to play sports.

Conclusions: The results on the effect of rs6265 BDNF polymorphic variants on the risk of depression and addition are inconsistent, indicating a significant association in some studies and none in others. Therefore, more studies are needed to determine how rs6265 affects gene expression and function.

Keywords

1. Ayyadhury, S.; Heese, K. Neurotrophins - More than Neurotrophic. Current Immunology Reviews 2007, 3, 189–215, doi:10.2174/157339507781483504. Open DOISearch in Google Scholar

2. Kelley, A.E.; Berridge, K.C. The Neuroscience of Natural Rewards: Relevance to Addictive Drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience 2002, 22, 3306–3311, doi:10.1523/JNEUROSCI.22-09-03306.2002. Open DOISearch in Google Scholar

3. Li, Y.; Xia, B.; Li, R.; Yin, D.; Liang, W. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Medical Science Monitor 2017, 23, 2805–2815, doi:10.12659/MSM.904670. Open DOISearch in Google Scholar

4. le Foll, B.; Diaz, J.; Sokoloff, P. A Single Cocaine Exposure Increases BDNF and D3 Receptor Expression: Implications for Drug-Conditioning. NeuroReport 2005, 16, 175–178, doi:10.1097/00001756-200502080-00022. Open DOISearch in Google Scholar

5. Robinson, T.E.; Berridge, K.C. The Neural Basis of Drug Craving: An Incentive-Sensitization Theory of Addiction. Brain Research Reviews 1993, 18, 247–291. Search in Google Scholar

6. Barde, Y.A.; Edgar, D.; Thoenen, H. Purification of a New Neurotrophic Factor from Mammalian Brain. The EMBO Journal 1982, 1, 549, doi:10.1002/j.1460-2075.1982.tb01207.x. Open DOISearch in Google Scholar

7. Chao, M. V.; Bothwell, M. Neurotrophins: To Cleave or Not to Cleave. Neuron 2002, 33, 9–12, doi:10.1016/S0896-6273(01)00573-6. Open DOISearch in Google Scholar

8. Lee, R.; Kermani, P.; Teng, K.K.; Hempstead, B.L. Regulation of Cell Survival by Secreted Proneurotrophins. Science (New York, N.Y.)2001, 294, 1945–1948, doi:10.1126/SCIENCE.1065057.11729324 Open DOISearch in Google Scholar

9. Pang, P.T.; Teng, H.K.; Zaitsev, E.; Woo, N.T.; Sakata, K.; Zhen, S.; Teng, K.K.; Yung, W.H.; Hempstead, B.L.; Lu, B. Cleavage of ProBDNF by TPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity. Science (New York, N.Y.)2004, 306, 487–491, doi:10.1126/SCIENCE.1100135. Open DOISearch in Google Scholar

10. Teng, H.K.; Teng, K.K.; Lee, R.; Wright, S.; Tevar, S.; Almeida, R.D.; Kermani, P.; Torkin, R.; Chen, Z.Y.; Lee, F.S.; et al. ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of P75NTR and Sortilin. The Journal of neuroscience : the official journal of the Society for Neuroscience 2005, 25, 5455–5463, doi:10.1523/JNEUROSCI.5123-04.2005.672499215930396 Open DOISearch in Google Scholar

11. Fleitas, C.; Piñol-Ripoll, G.; Marfull, P.; Rocandio, D.; Ferrer, I.; Rampon, C.; Egea, J.; Espinet, C. ProBDNF Is Modified by Advanced Glycation End Products in Alzheimer’s Disease and Causes Neuronal Apoptosis by Inducing P75 Neurotrophin Receptor Processing 11 Medical and Health Sciences 1109 Neurosciences. Molecular Brain 2018, 11, 1–16, doi:10.1186/S13041-018-0411-6/FIGURES/5. Open DOISearch in Google Scholar

12. Minichiello, L. TrkBSignalling Pathways in LTP and Learning. Nature reviews. Neuroscience 2009, 10, 850–860, doi:10.1038/NRN2738. Open DOISearch in Google Scholar

13. Zhang, J.; Yao, W.; Hashimoto, K. Brain-Derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-Related Depression and Potential Therapeutic Target s. Current neuropharmacology 2016, 14, 721–731, doi:10.2174/1570159X14666160119094646. Open DOISearch in Google Scholar

14. Finn, R.D.; Coggill, P.; Eberhardt, R.Y.; Eddy, S.R.; Mistry, J.; Mitchell, A.L.; Potter, S.C.; Punta, M.; Qureshi, M.; Sangrador-Vegas, A.; et al. The Pfam Protein Families Database: Towards a More Sustainable Future. Nucleic acids research 2016, 44, D279–D285, doi:10.1093/NAR/GKV1344. Open DOISearch in Google Scholar

15. Seidaha, N.G.; Benjannet, S.; Pareek, S.; Chrétien, M.; Murphy, R.A. Cellular Processing of the Neurotrophin Precursors of NT3 and BDNF by the Mammalian Proprotein Convertases. FEBS letters 1996, 379, 247–250, doi:10.1016/0014-5793(95)01520-5. Open DOISearch in Google Scholar

16. Pagni, M.; Ioannidis, V.; Cerutti, L.; Zahn-Zabal, M.; Jongeneel, C.V.; Hau, J.; Martin, O.; Kuznetsov, D.; Falquet, L. MyHits: Improvements to an Interactive Resource for Analyzing Protein Sequences. Nucleic Acids Research 2007, 35, W433, doi:10.1093/NAR/GKM352. Open DOISearch in Google Scholar

17. Notaras, M.; van den Buuse, M. Brain-Derived Neurotrophic Factor (BDNF): Novel Insight s into Regulation and Genetic Variation. Neuroscientist 2019, 25, 434–454, doi:10.1177/1073858418810142.30387693 Open DOISearch in Google Scholar

18. Mowla, S.J.; Farhadi, H.F.; Pareek, S.; Atwal, J.K.; Morris, S.J.; Seidah, N.G.; Murphyl, R.A. Biosynthesis and Post-Translational Processing of the Precursor to Brain-Derived Neurotrophic Factor. The Journal of biological chemistry 2001, 276, 12660–12666, doi:10.1074/JBC.M008104200.11152678 Open DOISearch in Google Scholar

19. D’Addario, C.; Dell’Osso, B.; Galimberti, D.; Palazzo, M.C.; Benatti, B.; Di Francesco, A.; Scarpini, E.; Altamura, A.C.; MacCarrone, M. Epigenetic Modulation of BDNF Gene in Patients with Major Depressive Disorder. Biological psychiatry 2013, 73, doi:10.1016/J.BIOPSYCH.2012.07.009.22901293 Open DOISearch in Google Scholar

20. Pruunsild, P.; Kazantseval, A.; Aid, T.; Palm, K.; Timmusk, T. Dissecting the Human BDNF Locus: Bidirectional Transcription, Complex Splicing, and Multiple Promoters. Genomics 2007, 90, 397–406, doi:10.1016/J.YGENO.2007.05.004.256888017629449 Open DOISearch in Google Scholar

21. An, J.J.; Gharami, K.; Liao, G.Y.; Woo, N.H.; Lau, A.G.; Vanevski, F.; Torre, E.R.; Jones, K.R.; Feng, Y.; Lu, B.; et al. Distinct Role of Long 3’ UTR BDNF MRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons. Cell 2008, 134, 175–187, doi:10.1016/J.CELL.2008.05.045.252720718614020 Open DOISearch in Google Scholar

22. Lau, A.G.; Irier, H.A.; Gu, J.; Tian, D.; Ku, L.; Liu, G.; Xia, M.; Fritsch, B.; Zheng, J.Q.; Dingledine, R.; et al. Distinct 3’UTRs Differentially Regulate Activity-Dependent Translation of Brain-Derived Neurotrophic Factor (BDNF). Proceedings of the National Academy of Sciences of the United States of America 2010, 107, 15945–15950, doi:10.1073/PNAS.1002929107. Open DOISearch in Google Scholar

23. Matsumoto, T.; Rauskolb, S.; Polack, M.; Klose, J.; Kolbeck, R.; Korte, M.; Barde, Y. A. Biosynthesis and Processing of Endogenous BDNF: CNS Neurons Store and Secrete BDNF, Not pro-BDNF. Nature neuroscience 2008, 11, 131–133, doi:10.1038/NN2038. Open DOISearch in Google Scholar

24. Lein, E.S.; Hawrylycz, M.J.; Ao, N.; Ayres, M.; Bensinger, A.; Bernard, A.; Boe, A.F.; Boguski, M.S.; Brockway, K.S.; Byrnes, E.J.; et al. Genome-Wide Atlas of Gene Expression in the Adult Mouse Brain. Nature 2006 445:71242006, 445, 168–176, doi:10.1038/nature05453. Open DOISearch in Google Scholar

25. Sohrabji, F.; Miranda, R.C.G.; Toran-Allerand, C.D. Identification of a Putative Estrogen Response Element in the Gene Encoding Brain-Derived Neurotrophic Factor. Proceedings of the National Academy of Sciences of the United States of America 1995, 92, 11110, doi:10.1073/PNAS.92.24.11110. Open DOISearch in Google Scholar

26. Hill, R.A.; Wu, Y.W.C.; Kwek, P.; Van den Buuse, M. Modulatory Effects of Sex Steroid Hormones on Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Expression during Adolescent Development in C57Bl/6 Mice. Journal of neuroendocrinology 2012, 24, 774–788, doi:10.1111/J.1365-2826.2012.02277.X. Open DOISearch in Google Scholar

27. Yang, J.; Siao, C.J.; Nagappan, G.; Marinic, T.; Jing, D.; McGrath, K.; Chen, Z.Y.; Mark, W.; Tessarollo, L.; Lee, F.S.; et al. Neuronal Release of ProBDNF. Nature neuroscience 2009, 12, 113–115, doi:10.1038/NN.2244. Open DOISearch in Google Scholar

28. Egan, M.F.; Kojima, M.; Callicott, J.H.; Goldberg, T.E.; Kolachana, B.S.; Bertolino, A.; Zaitsev, E.; Gold, B.; Goldman, D.; Dean, M.; et al. The BDNF Val66met Polymorphism Affects Activity-Dependent Secret ion of BDNF and Human Memory and Hippocampal Function. Cell 2003, 112, 257–269, doi:10.1016/S0092-8674(03)00035-7. Open DOISearch in Google Scholar

29. Chen, Z.Y.; Patel, P.D.; Sant, G.; Meng, C.X.; Teng, K.K.; Hempstead, B.L.; Lee, F.S. Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons. Journal of Neuroscience 2004, 24, 4401–4411, doi:10.1523/JNEUROSCI.0348-04.2004.672945015128854 Open DOISearch in Google Scholar

30. Depression Available online: https://www.who.int/health-topics/depression#tab=tab_1 (accessed on 10 March 2022). Search in Google Scholar

31. Fratelli, C.F.; Siqueira, J.W.; Gontijo, B.R.; Santos, M. de L.; Silva, C.M. de S.; Silva, I.C.R. da BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder. Behavioural Neurology 2021, 2021, 1–16, doi:10.1155/2021/7117613.857559834760029 Open DOISearch in Google Scholar

32. Aldoghachi, A.F.; Tor, Y.S.; Redzun, S.Z.; Bin Lokman, K.A.; Abdul Razaq, N.A.; Shahbudin, A.F.; Badamasi, I.M.; Cheah, P.S.; Stanslas, J.; Veerakumarasivam, A.; et al. Screening of Brain-Derived Neurotrophic Factor (BDNF) Single Nucleotide Polymorphisms and Plasma BDNF Levels among Malaysian Major Depressive Disorder Patients. PLoS ONE2019, 14, doi:10.1371/JOURNAL.PONE.0211241.634545930677092 Open DOISearch in Google Scholar

33. Hwang, J.P.; Tsai, S.J.; Hong, C.J.; Yang, C.H.; Lirng, J.F.; Yang, Y.M. The Val66Met Polymorphism of t he Brain-Derived Neurotrophic-Factor Gene Is Associated with Geriatric Depression. Neurobiology of Aging 2006, 27, 1834–1837, doi:10.1016/J.NEUROBIOLAGING.2005.10.013.16343697 Open DOISearch in Google Scholar

34. Taylor, W.D.; Züchner, S.; Mcquoid, D.R.; Steffens, D.C.; Speer, M.C.; Krishnan, K.R.R. Allelic Differences in the Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Late-Life Depression. The American Journal of Geriatric Psychiatry 2007, 15, 850–857, doi:10.1097/JGP.0B013E318050C9D5.17911362 Open DOISearch in Google Scholar

35. Ribeiro, L.; Busnello, J. V.; Cantor, R.M.; Whelan, F.; Whittaker, P.; Deloukas, P.; Wong, M.-L.; Licinio, J. The Brain-Derived Neurotrophic Factor Rs6265 (Val66Met) Polymorphism and Depression in Mexican-Americans. Neuroreport 2007, 18, 1291, doi:10.1097/WNR.0B013E328273BCB0.268683617632285 Open DOISearch in Google Scholar

36. Youssef, M.M.; Underwood, M.D.; Huang, Y.Y.; Hsiung, S. chi; Liu, Y.; Simpson, N.R.; Bakalian, M.J.; Rosoklija, G.B.; Dwork, A.J.; Arango, V.; et al. Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide. International Journal of Neuropsychopharmacology 2018, 21, 528, doi:10.1093/IJNP/PYY008. Open DOISearch in Google Scholar

37. Cruz-Fuentes, C.S.; Benjet, C.; Martínez-Levy, G.A.; Pérez-Molina, A.; Briones-Velasco, M.; Suárez-González, J. BDNF Met66 Modulates the Cumulative Effect of Psychosocial Childhood Adversities on Major Depression in Adolescents. Brain and Behavior 2014, 4, 290, doi:10.1002/BRB3.220. Open DOISearch in Google Scholar

38. Sun, M.M.; Yang, L.M.; Wang, Y.; Feng, X.; Cui, K.Y.; Liu, L.F.; Chen, Z.Y. BDNF Val66Met Polymorphism and Anxiety/Depression Symptoms in Schizophrenia in a Chinese Han Population. Psychiatric genetics 2013, 23, 124–129, doi:10.1097/YPG.0B013E328360C866.23532065 Open DOISearch in Google Scholar

39. Kang, H.J.; Bae, K.Y.; Kim, S.W.; Shin, I.S.; Hong, Y.J.; Ahn, Y.; Jeong, M.H.; Yoon, J.S.; Kim, J.M. BDNF Val66met Polymorphism and Depressive Disorders in Patients with Acute Coronary Syndrome. Journal of affective disorders 2016, 194, 1–8, doi:10.1016/J.JAD.2016.01.033.26795846 Open DOISearch in Google Scholar

40. Verhagen, M.; Van Der Meij, A.; Van Deurzen, P.M.; Janzing, J.; Arias-Vásquez, A.; Buitelaar, J.; Franke, B. Meta-Analysis of the BDNF Val66Met Polymorphism in Major Depressive Disorder: Effects of Gender and Ethnicity. Molecular Psychiatry 2010 15:32008, 15, 260–271, doi:10.1038/mp.2008.109.18852698 Open DOISearch in Google Scholar

41. Gyekis, J.P.; Yu, W.; Dong, S.; Wang, H.; Qian, J.; Kota, P.; Yang, J. No Association of Genetic Variants in BDNF With Major Depression: A Meta- and Gene-Based Analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2013, 162, 61, doi:10.1002/AJMG.B.32122.372512823184535 Open DOISearch in Google Scholar

42. Pei, Y.; Smith, A.K.; Wang, Y.; Pan, Y.; Yang, J.; Chen, Q.; Pan, W.; Bao, F.; Zhao, L.; Tie, C.; et al. The Brain-Derived Neurotrophic-Factor (BDNF) Val66met Polymorphism Is Associated with Geriatric Depression: A Meta-Analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2012, 159B, 560–566, doi:10.1002/AJMG.B.32062. Open DOISearch in Google Scholar

43. Verhagen, M.; van der Meij, A.; van Deurzen, P.M.; Janzing, J.; Arias-Vásquez, A.; Buitelaar, J.; Franke, B. Meta-Analysis of the BDNF Val66Met Polymorphism in Major Depressive Disorder: Effects of Gender and Ethnicity. Molecular Psychiatry 2010 15:32008, 15, 260–271, doi:10.1038/mp.2008.109.18852698 Open DOISearch in Google Scholar

44. Zou, Z.; Wang, H.; d’OleireUquillas, F.; Wang, X.; Ding, J.; Chen, H. Definition of Substance and Non-Substance Addiction. Advances in experimental medicine and biology 2017, 1010, 21–41, doi:10.1007/978-981-10-5562-1_2.29098666 Open DOISearch in Google Scholar

45. Feng, J.; Nestler, E.J. Epigenetic Mechanisms of Drug Addiction. Current opinion in neurobiology 2013, 23, 521–528, doi:10.1016/J.CONB.2013.01.001. Open DOISearch in Google Scholar

46. GLOBAL OVERVIEW: DRUG DEMAND DRUG SUPPLY. Search in Google Scholar

47. Europejski Raport Narkotykowy Tendencje i Osiągnięcia., doi:10.2810/251039. Open DOISearch in Google Scholar

48. Morris, R.G.M. Long-Term Potentiation and Memory. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003, 358, 643–647, doi:10.1098/RSTB.2002.1230.169317112740109 Open DOISearch in Google Scholar

49. Suriyaprom, K.; Tungtrongchitr, R.; Thawnashom, K.; Pimainog, Y. BDNF Val66Met Polymorphism and Serum Concentrations of BDNF with Smoking in Thai Males. Genetics and molecular research : GMR2013, 12, 4925–4933, doi:10.4238/2013.OCTOBER.24.3.24301752 Open DOISearch in Google Scholar

50. Zhang, X.Y.; Chen, D.C.; Xiu, M.H.; Luo, X.; Zuo, L.; Haile, C.N.; Kosten, T.A.; Kosten, T.R. BDNF Val66Met Variant and Smoking in a Chinese Population. PloS one 2012, 7, doi:10.1371/JOURNAL.PONE.0053295.353229423285275 Open DOISearch in Google Scholar

51. Nees, F.; Wit t, S.H.; Dinu-Biringer, R.; Lourdusamy, A.; Tzschoppe, J.; Vollstädt-Klein, S.; Millenet, S.; Bach, C.; Poustka, L.; Banaschewski, T.; et al. BDNF Val66Met and Reward-Related Brain Function in Adolescents: Role for Early Alcohol Consumption. Alcohol (Fayetteville, N.Y.)2015, 49, 103–110, doi:10.1016/J.ALCOHOL.2014.12.004. Open DOISearch in Google Scholar

52. Su, H.; Tao, J.; Zhang, J.; Xie, Y.; Sun, Y.; Li, L.; Xu, K.; Han, B.; Lu, Y.; Sun, H.; et al. An Association between BDNF Val66Met Polymorphism and Impulsivity in Methamphetamine Abusers. Neuroscience Letters 2014, 582, 16–20, doi:10.1016/J.NEULET.2014.08.030.25168604 Open DOISearch in Google Scholar

53. Montag, C.; Basten, U.; Stelzel, C.; Fiebach, C.J.; Reuter, M. The BDNF Val66Met Polymorphism and Smoking. Neuroscience letters 2008, 442, 30–33, doi:10.1016/J.NEULET.2008.06.064.18602452 Open DOISearch in Google Scholar

54. Wojnar, M.; Brower, K.J.; Strobbe, S.; Ilgen, M.; Matsumoto, H.; Nowosad, I.; Sliwersk a, E.; Burmeister, M. A ssociation between Val66Met Brain-Derived Neurotrophic Factor (BDNF) Gene Polymorphism and Post-Treatment Relapse in Alcohol Dependence. Alcoholism, clinical and experimental research 2009, 33, 693, doi:10.1111/J.1530-0277.2008.00886.X. Open DOISearch in Google Scholar

55. Hou, H.; Qing, Z.; Jia, S.; Zhang, X.; Hu, S.; Hu, J. Influence of Brain-Derived Neurotrophic Factor (Val66Met) Genetic Polymorphism on the Ages of Onset for Heroin Abuse in Males. Brain Research 2010, 1353, 245–248, doi:10.1016/J.BRAINRES.2010.07.022. Open DOISearch in Google Scholar

56. Iamjan, S.A.; Thanoi, S.; Watiktinkorn, P.; Nudmamud-Thanoi, S.; Reynolds, G.P. BDNF (Val66Met) Genetic Polymorphism Is Associated with Vulnerability for Methamphetamine Dependence. PHARMACOGENOMICS 2015, 16, 1541–1545, doi:10.2217/PGS.15.96. Open DOISearch in Google Scholar

57. Nedic, G.; NikolacPerkovic, M.; NenadicSviglin, K.; Muck-Seler, D.; Borovecki, F.; Pivac, N. Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Alcohol-Related Phenotypes. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2013, 40, 193–198, doi:10.1016/J.PNPBP.2012.09.005. Open DOISearch in Google Scholar

58. Meng, C.; Lan, J.; Wang, Y.; Song, M.; Gao, X.; Ran, L.; Moira, S.; Wang, W. Influence of Brain-Derived Neurotrophic Factor Genetic Polymorphisms on the Ages of Onset for Heroin Dependence in a Chinese Population. Genetic testing and molecular biomarkers 2012, 16, 1044–1050, doi:10.1089/GTMB.2012.0016. Open DOISearch in Google Scholar

59. Su, N.; Zhang, L.; Fei, F.; Hu, H.; Wang, K.; Hui, H.; Jiang, X.F.; Li, X.; Zhen, H.N.; Li, J.; et al. The Brain-Derived Neurotrophic Factor Is Associated with Alcohol Dependence-Related Depression and Antidepressant Response. Brain research 2011, 1415, 119–126, doi:10.1016/J.BRAINRES.2011.08.005. Open DOISearch in Google Scholar

60. Tajbakhsh, A.; Alimardani, M.; A sghari, M.; Abedini, S.; SaghafiKhadem, S.; NesaeiBajestani, A.; Alipoor, F.; Alidoust, M.; Savardashtaki, A.; Hashemian, P.; et al. Association of PICK1 and BDNF Variations with Increased Risk of Methamphetamine Dependence among Iranian Population: A Case-Control Study. BMC medical genomics 2021, 14, doi:10.1186/S12920-021-00873-7. Open DOISearch in Google Scholar

61. De Moor, M.H.M.; Spector, T.D.; Cherkas, L.F.; Falchi, M.; Hottenga, J.J.; Boomsma, D.I.; De Geus, E.J.C. Genome-Wide Linkage Scan for Athlete Status in 700 British Female DZ Twin Pairs. Twin research and human genetics : the official journal of the International Society for Twin Studies 2007, 10, 812–820, doi:10.1375/TWIN.10.6.812. Open DOISearch in Google Scholar

62. Egan, M.F.; Kojima, M.; Callicott, J.H.; Goldberg, T.E.; Kolachana, B.S.; Bertolino, A.; Zaitsev, E.; Gold, B.; Goldman, D.; Dean, M.; et al. The BDNF Val66met Polymorphism Affects Activity-Dependent Secret ion of BDNF and Human Memory and Hippocampal Function. Cell 2003, 112, 257–269, doi:10.1016/S0092-8674(03)00035-7. Open DOISearch in Google Scholar

63. Murtagh, C.F.; Brownlee, T.E.; Rienzi, E.; Roquero, S.; Moreno, S.; Huertas, G.; Lugioratto, G.; Baumert, P.; Turner, D.C.; Lee, D.; et al. The Genetic Profile of Elite Youth Soccer Players and Its Association with Power and Speed Depends on Maturity Status. PLoS ONE2020, 15, doi:10.1371/JOURNAL.PONE.0234458.730777632569264 Open DOISearch in Google Scholar

64. Kambouris, M.; Ntalouka, F.; Ziogas, G.; Maffulli, N. Predictive Genomics DNA Profiling for Athletic Performance. Recent Patents on DNA and Gene Sequences 2012, 6, 229–239, doi:10.2174/187221512802717321.22827597 Open DOISearch in Google Scholar

65. Lemos, J.R.; Alves, C.R.; de Souza, S.B.C.; Marsiglia, J.D.C.; Silva, M.S.M.; Pereira, A.C.; Teixeira, A.L.; Vieira, E.L.M.; Krieger, J.E.; Negrão, C.E.; et al. Peripheral Vascular Reactivity and Serum BDNF Responses to Aerobic Training Are Impaired by the BDNF Val66Met Polymorphism. Physiological genomics 2016, 48, 116–123, doi:10.1152/PHYSIOLGENOMICS.00086.2015.26603150 Open DOISearch in Google Scholar

66. Asai, T.; Abe, D.; Doi, H.; Tanaka, C.; Ohishi, K.; Maeda, H.; Wada, T.; Takahashi, Y.; Nakahata, Y.; Shinohara, K. Characteristics of the BDNF Val66Met Polymorphism in Competitive Swimmers and Judo Athletes. Acta Medica Nagasakiensia 2020, 64, 23–29, doi:10.11343/AMN.64.23. Open DOISearch in Google Scholar

67. Jacob, Y.; Chivers, P.; Anderton, R.S. Genetic Predictors of Match Performance in Sub-Elite Australian Football Players: A Pilot Study. Journal of Exercise Science & Fitness 2019, 17, 41–46, doi:10.1016/J.JESF.2018.10.007.635372930740132 Open DOISearch in Google Scholar

68. Mang, C.S.; McEwen, L.M.; MacIsaac, J.L.; Snow, N.J.; Campbell, K.L.; Kobor, M.S.; Ross, C.J.D.; Boyd, L.A. Exploring Genetic Influences Underlying Acute Aerobic Exercise Effects on Motor Learning. Scientific Reports 2017 7:12017, 7, 1–10, doi:10.1038/s41598-017-12422-3.560896728935933 Open DOISearch in Google Scholar

69. Hashimoto, K. BDNF Variant Linked to Anxiety-Related Behaviors. BioEssays : news and reviews in molecular, cellular and developmental biology 2007, 29, 116–119, doi:10.1002/BIES.20534.17226799 Open DOISearch in Google Scholar

70. Fratelli, C.F.; Siqueira, J.W.; Gontijo, B.R.; Santos, M. de L.; Silva, C.M. de S.; Silva, I.C.R. da BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder. Behavioural Neurology 2021, 2021, 1–16, doi:10.1155/2021/7117613.857559834760029 Open DOISearch in Google Scholar

71. Tajbakhsh, A.; Alimardani, M.; A sghari, M.; Abedini, S.; SaghafiKhadem, S.; NesaeiBajestani, A.; Alipoor, F.; Alidoust, M.; Savardashtaki, A.; Hashemian, P.; et al. Association of PICK1 and BDNF Variations with Increased Risk of Methamphetamine Dependence among Iranian Population: A Case-Control Study. BMC medical genomics 2021, 14, doi:10.1186/S12920-021-00873-7. Open DOISearch in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo