1. bookVolume 67 (2021): Issue 3 (September 2021)
Journal Details
License
Format
Journal
eISSN
2449-8343
First Published
04 Apr 2014
Publication timeframe
4 times per year
Languages
English
access type Open Access

Phytochemical analysis and cytotoxicity evaluation of flowering buds of Bauhinia variegata L.

Published Online: 15 Nov 2021
Volume & Issue: Volume 67 (2021) - Issue 3 (September 2021)
Page range: 27 - 36
Received: 25 Oct 2020
Accepted: 20 May 2021
Journal Details
License
Format
Journal
eISSN
2449-8343
First Published
04 Apr 2014
Publication timeframe
4 times per year
Languages
English
Summary

Introduction: Bauhinia variegata is used in traditional medicine in Pakistan.

Objective: The present study was designated to analyze phytochemical screening and cytotoxicity assay of crude aqueous and methanol extracts of flowering buds of Bauhinia variegata.

Methods: Qualitative and quantitative phytochemical screening of both extracts were performed by using standard protocols while brine shrimp lethality assay was conducted for cytotoxicity analysis of both extracts.

Results: The highest levels of phenolics, flavonoids and terpenoids were observed in methanol extract with respective standard drugs. The aminoacid content was highest followed by phenol and flavonoids in crude aqueous extract of the raw materials. In cytotoxic studies (brine shrimp lethality assay) the use of methanol extract was reported as potent with LD50 of 241.778 µg/ml as compared to aqueous extract with LD50 of 489.7061 µg/ml.

Conclusion: This study reveals that the presence of bioactive compounds in both extracts are responsible for the treatment of various ailments and being utilized by the traditional folks as a food as well. And showed that methanol extract possess cytotoxic activity and thus needs further scientific intervention for its value addition.

Keywords

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