1. bookVolume 11 (2018): Issue 3 (October 2018)
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19 Jun 2009
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access type Open Access

Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration

Published Online: 18 Oct 2019
Page range: 217 - 220
Received: 21 Nov 2017
Accepted: 17 Dec 2017
Journal Details
License
Format
Journal
First Published
19 Jun 2009
Publication timeframe
4 times per year
Languages
English

Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are present in dementia-like disorders. In the present work, we tested whether 6 weeks lasting handling of young adult rats could revert memory impairment induced by trimethyltin (TMT) (7.5 mg/kg, intraperitoneally). Testing rats in Morris water maze revealed significant effect of TMT as well significant effect of handling. We observed improvement of spatial memory also between healthy, non-degenerated rats as well as degenerated rats, represented by shorter latency onto the platform. In our paper, we report beneficial effect of handling on spatial memory that is in compliance with published works about beneficial effect of cognitive therapy and training in patients with early stage of Alzheimer's disease and dementia.

Keywords

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