1. bookVolume 131 (2021): Issue 1 (January 2021)
Journal Details
First Published
23 Apr 2014
Publication timeframe
1 time per year
access type Open Access

Controversies about selenium supplementation

Published Online: 18 Aug 2021
Volume & Issue: Volume 131 (2021) - Issue 1 (January 2021)
Page range: 20 - 26
Journal Details
First Published
23 Apr 2014
Publication timeframe
1 time per year

Introduction. Selenium (Se) is a trace element found mainly in meat, seafood, nuts and grains. Se is found in selenoproteins such as selenocystein or selenomethionin. A well balanced diet provides enough Se. Many regulatory and metabolic enzymes contain Se as their component, which is why Se supplementation is used in the treatment as well as prevention of multiple disorders. Se may, however, be toxic if overdosed.

Aim. The aim of this review is to summarize the data about functions of Se in human body and to discuss its use in treatment and prevention of diseases.

Materials and methods. The search was conducted using the PubMed and Google Scholar databases in March and April 2020. The key words used were: ‘selenium’, ‘cardiovascular disease’, ‘selenium supplementation’, ‘Keshan disease’, ‘source of selenium’. A total of 68 articles were analysed.

Results. The first cases of chronic Se deficiency cases were documented 85 years ago in China. The patients with cardiomyopathy, extensive fibrosis and degenerative changes in the heart were diagnosed with Keshan disease. Human selenoproteonome consists of at least 25 selenoproteins. Se plays a role in immunity and metabolism via its role in functioning of numerous enzymes: glutathione peroxidase, thioredoxine and methionine sulfoxide reductase, methionine-sulfoxide reductase B1. Se plays a role in glucose homeostasis, Alzheimer’s disease, thyroid disorders, infectious, inflammatory diseases, vascular diseases and fertility.

Conclusion. Se deficiency increases the risk of Keshan disease, but there is not enough evidence to recommend its supplementation for prevention of cardiovascular disease. However, Se status is important part of health assessment. Se supplementation should not exceed the dose of 55μg/day.


1. Steinbrenner H, Al-Quraishy S, Dkhil MA, et al. Dietary selenium in adjuvant therapy of viral and bacterial infections. Adv Nutr. 2015;6(1):73-82.10.3945/an.114.007575428828225593145 Search in Google Scholar

2. Yang L, Wang W, Chen J, Wang N, Zheng G. A comparative study of resveratrol and resveratrol-functional selenium nanoparticles: Inhibiting amyloid β aggregation and reactive oxygen species formation properties. J Biomed Mater Res A. 2018;106(12):3034-41.10.1002/jbm.a.3649330295993 Search in Google Scholar

3. Ingles DP, Cruz Rodriguez JB, Garcia H. Supplemental vitamins and minerals for cardiovascular disease prevention and treatment. Curr Cardiol Rep. 2020;22(4):22.10.1007/s11886-020-1270-132067177 Search in Google Scholar

4. Sadat Najib F, Poordast T, Rezvan Nia M, Hossein Dabbaghmanesh M. Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial. Int J Reprod Biomed (Yazd). 2020;18(1):57-64.10.18502/ijrm.v18i1.6201699612432043072 Search in Google Scholar

5. Solovyev N. Selenoprotein P and its potential role in Alzheimer’s disease. Hormones (Athens). 2020;19(1):73-9.10.1007/s42000-019-00112-w31250406 Search in Google Scholar

6. Winther KH, Rayman MP, Bonnema SJ, Hegedüs L. Selenium in thyroid disorders – essential knowledge for clinicians. Nat Rev Endocrinol. 2020;16:165-76.10.1038/s41574-019-0311-632001830 Search in Google Scholar

7. Gombart AF, Pierre A, Maggini S. A review of micronutrients and the immune system – working in harmony to reduce the risk of infection. Nutrients. 2020;12(1):236.10.3390/nu12010236701973531963293 Search in Google Scholar

8. Qian F, Misra S, Prabhu KS. Selenium and selenoproteins in prostanoid metabolism and immunity. Crit Rev Biochem Mol Biol. 2019;54 (6):484-516.10.1080/10409238.2020.1717430712210431996052 Search in Google Scholar

9. Mintziori G, Mousiolis A, Duntas LH, Goulis DG. Evidence for a manifold role of selenium in infertility. Hormones (Athens). 2020;19(1):55-9.10.1007/s42000-019-00140-631701489 Search in Google Scholar

10. Raganová A, Gažová A, Tomo I, Kristová V. Selenium in the prevention and subsidiary therapy of cancer of soft tissues. Ceska Slov Farm. 2018;67(2):66-70. Search in Google Scholar

11. Hargreaves IP, Mantle D. Supplementation with selenium and coenzyme Q10 in critically ill patients. Br J Hosp Med (Lond). 2019;80(10):589-93.10.12968/hmed.2019.80.10.58931589506 Search in Google Scholar

12. Gladyshev VN, Arnér ES, Berry MJ, et al. Selenoprotein gene nomenclature. J Biol Chem. 2016;291(46):24036-40.10.1074/jbc.M116.756155510492927645994 Search in Google Scholar

13. Barale C, Cavalot F, Frascaroli C, et al. Association between high on-aspirin platelet reactivity and reduced superoxide dismutase activity in patients affected by Type 2 Diabetes Mellitus or primary hypercholesterolemia. Int J Mol Sci. 2020;21(14):4983.10.3390/ijms21144983740431832679712 Search in Google Scholar

14. Forgione MA, Cap A, Liao R, et al. Heterozygous cellular glutathione peroxidase deficiency in the mouse - Abnormalities in vascular and cardiac function and structure. Circulation. 2020;106(9):1154-8.10.1161/01.CIR.0000026820.87824.6A12196344 Search in Google Scholar

15. Huang JQ, Ren FZ, Jiang YY, et al. Selenoproteins protect against avian nutritional muscular dystrophy by metabolizing peroxides and regulating redox/apoptotic signaling. Free Radic Biol Med. 2015;83:129-38.10.1016/j.freeradbiomed.2015.01.03325668720 Search in Google Scholar

16. Rose AH, Hoffmann PR. Part – selenoproteins and cardiovascular stress. Thromb Haemost. 2015;113(3):494-504.10.1160/TH14-07-0603570500825354851 Search in Google Scholar

17. Lu J, Holmgren A. The thioredoxin antioxidant system. Free Radic Biol Med. 2014;66:75-87.10.1016/j.freeradbiomed.2013.07.03623899494 Search in Google Scholar

18. Chong CR, Chan WP, Nguyen TH, et al. Thioredoxin – interacting protein: Pathophysiology and emerging pharmacotherapeutics in cardiovascular disease and diabetes. Cardiovasc Drugs Ther. 2014;28(4):347-60.10.1007/s10557-014-6538-525088927 Search in Google Scholar

19. Scalcon V, Bindoli A, Rigobello MP. Significance of the mitochondrial thioredoxin reductase in cancer cells: An update on role, targets and inhibitors. Free Radic Biol Med. 2018;127:62-79.10.1016/j.freeradbiomed.2018.03.04329596885 Search in Google Scholar

20. Iqbal MA, Eftekharpour E. Regulatory role of redox balance in determination of neural precursor cell fate. Stem Cells Int. 2017;2017:9209127. Search in Google Scholar

21. Razavi AC, Bazzano LA, He J, et al. Novel findings from a metabolomics study of left ventricular diastolic function: The Bogalusa Heart Study. J Am Heart Assoc. 2020;9(3):e015118.10.1161/JAHA.119.015118703387531992159 Search in Google Scholar

22. Jiang B, Adams Z, Moonah S, et al The antioxidant enzyme methionine sulfoxide reductase A (MsrA) interacts with Jab1/CSN5 and regulates its function. Antioxidants (Basel). 2020;9(5):452.10.3390/antiox9050452727866032456285 Search in Google Scholar

23. Méndez AA, Pena LB, Benavides MP, Gallego SM. Priming with NO controls redox state and prevents cadmium-induced general up-regulation of methionine sulfoxide reductase gene family in Arabidopsis. Biochimie. 2016;131:128-36.10.1016/j.biochi.2016.09.02127702579 Search in Google Scholar

24. Lourenço Dos Santos S, Petropoulos I, Friguet B. The oxidized protein repair enzymes methionine sulfoxide reductases and their roles in protecting against oxidative stress, in ageing and in regulating protein function. Antioxidants (Basel). 2018;7(12):191.10.3390/antiox7120191631603330545068 Search in Google Scholar

25. Pitts MW, Hoffmann PR. Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis. Cell Calcium. 2018;70:76-86.10.1016/j.ceca.2017.05.001567136928506443 Search in Google Scholar

26. Addinsall AB, Martin SD, Collier F, et al. Differential regulation of cellular stress responses by the endoplasmic reticulum- resident Selenoprotein S (Seps1) in proliferating myoblasts versus myotubes. Physiol Rep. 2018;6(24).10.14814/phy2.13926629645930557449 Search in Google Scholar

27. Prajapati RS, Mitter R, Vezzaro A, Ish-Horowicz D. Greb1 is required for axial elongation and segmentation in vertebrate embryos. Biol Open. 2020;9(2):bio047290.10.1242/bio.047290704445131988092 Search in Google Scholar

28. Addinsall AB, Wright CR, Shaw CS, et al. Deficiency of selenoprotein S, an endoplasmic reticulum resident oxidoreductase, impairs the contrac-tile function of fast-twitch hindlimb muscles. Am J Physiol Regul Integr Comp Physiol. 2018;315(2):380-96.10.1152/ajpregu.00244.201729668323 Search in Google Scholar

29. Moghadaszadeh B, Rider BE, Lawlor MW, et al. Selenoprotein N deficiency in mice is associated with abnormal lung development. FASEB J. 2013;27(4):1585-99.10.1096/fj.12-212688360652723325319 Search in Google Scholar

30. Ardissone A, Bragato C, Blasevich F, et al. SEPN1-related myopathy in three patients: novel mutations and diagnostic clues. Eur J Pediatr. 2016;175(8):1113-8.10.1007/s00431-015-2685-326780752 Search in Google Scholar

31. Scoto M, Cirak S, Mein R, et al SEPN1-related myopathies: clinical course in a large cohort of patients. Neurology. 2011;76(24):2073-8.10.1212/WNL.0b013e31821f467c21670436 Search in Google Scholar

32. Benstoem C, Goetzenich A, Kraemer S, et al. Selenium and its supplementation in cardiovascular disease – What do we know? Nutrients. 2015;7(5):3094-118.10.3390/nu7053094444674125923656 Search in Google Scholar

33. Zhou H, Wang T, Li Q, Li D. Prevention of Keshan disease by selenium supplementation: A systematic review and meta-analysis. Biol Trace Elem Res. 2018;186(1):98-105.10.1007/s12011-018-1302-529627894 Search in Google Scholar

34. Loscalzo J. Keshan disease, selenium deficiency, and the selenoproteome. N Engl J Med. 2014;370(18):1756-60.10.1056/NEJMcibr140219924785212 Search in Google Scholar

35. Gaaloul I, Riabi S, Harrath R, et al. Coxsackievirus B detection in cases of myocarditis, myopericarditis, pericarditis and dilated cardiomyopathy in hospitalized patients. Mol Med Rep. 2014;10(6):2811-8.10.3892/mmr.2014.2578422742525241846 Search in Google Scholar

36. Chen J. An original discovery: Selenium deficiency and Keshan disease (an endemic heart disease). Asia Pac J Clin Nutr. 2012;21(3):320-6. Search in Google Scholar

37. Ju W, Li X, Li Z, et al. The effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of randomized controlled trials. J Trace Elem Med Biol. 2017;44:8-16.10.1016/j.jtemb.2017.04.00928965605 Search in Google Scholar

38. Roman M, Jitaru P, Barbante C. Selenium biochemistry and its role for human health. Metallomics. 2014;6(1):25-54.10.1039/C3MT00185G Search in Google Scholar

39. Lin SM, Yang MH. Arsenic, selenium, and zinc in patients with blackfoot disease. Biol Trace Elem Res. 1998;15:9. Search in Google Scholar

40. Bastola MM, Locatis C, Maisiak R, Fontelo P. Selenium, copper, zinc and hypertension: an analysis of the National Health and Nutrition Examination Survey (2011-2016). BMC Cardiovasc Disord. 2020;20. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995060.]10.1186/s12872-020-01355-x699506032005161 Search in Google Scholar

41. Su L, Jin Y, Unverzagt FW, et al. Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort. J Nutr Health Aging. 2016;20(10):983-8.10.1007/s12603-016-0700-727925137 Search in Google Scholar

42. Kuruppu D, Hendrie HC, Yang L, Gao S. Selenium levels and hypertension: a systematic review of the literature. Public Health Nutr. 2014;17(6):1342-52.10.1017/S1368980013000992399064723590757 Search in Google Scholar

43. Zhang X, Liu C, Guo J, Song Y. Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials. Eur J Clin Nutr. 2016;70(2):162-9.10.1038/ejcn.2015.7825990689 Search in Google Scholar

44. Rayman MP. Selenium intake, status, and health: a complex relationship. Hormones (Athens). 2019;19(1):9-14.10.1007/s42000-019-00125-5703305731388899 Search in Google Scholar

45. Reich HJ, Hondal RJ. Why Nature Chose Selenium. ACS Chem Biol. 2016;11(4):821–841.10.1021/acschembio.6b0003126949981 Search in Google Scholar

46. Rees K, Hartley L, Day C, et al. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013;(1):CD009671.10.1002/14651858.CD009671.pub2743329123440843 Search in Google Scholar

47. Vinceti M, Filippini T, Rothman KJ. Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis. Eur J Epidemiol. 2018;33(9):789-810.10.1007/s10654-018-0422-829974401 Search in Google Scholar

48. Ogawa-Wong AN, Berry MJ, Seale LA. Selenium and metabolic disorders: An emphasis on type 2 diabetes risk. Nutrients. 2016 6;8(2):80.10.3390/nu8020080477204426861388 Search in Google Scholar

49. Jablonska E, Reszka E, Gromadzinska J, et al. The effect of selenium supplementation on glucose homeostasis and the expression of genes related to glucose metabolism. Nutrients. 2016;8(12): E772.10.3390/nu8120772518842727983572 Search in Google Scholar

50. Mehdi Y, Hornick J-L, Istasse L, Dufrasne I. Selenium in the environment, metabolism and involvement in body functions. Molecules. 2013;18(3):3292-311.10.3390/molecules18033292627013823486107 Search in Google Scholar

51. Ren F, Chen X, Hesketh J, et al. Selenium promotes T-Cell response to TCR-stimulation and ConA, but not PHA in primary porcine splenocytes. PLoS One. 2012;7(4). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328446.]10.1371/journal.pone.0035375332844622530011 Search in Google Scholar

52. Sordillo LM. Selenium-dependent regulation of oxidative stress and immunity in periparturient dairy cattle. Vet Med Int. 2013. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557619.]10.1155/2013/154045355761923401850 Search in Google Scholar

53. Mattmiller SA, Carlson BA, Sordillo LM. Regulation of inflammation by selenium and selenoproteins: impact on eicosanoid biosynthesis. J Nutr Sci. 2013;2:e28.10.1017/jns.2013.17415332425191577 Search in Google Scholar

54. Lopreiato V, Mezzetti M, Cattaneo L, et al. Role of nutraceuticals during the transition period of dairy cows: a review. J Anim Sci Biotechnol. 2020;11:96.10.1186/s40104-020-00501-x745057432864127 Search in Google Scholar

55. Sordillo LM. Selenium-dependent regulation of oxidative stress and immunity in periparturient dairy cattle. Vet Med Int. 2013;2013:154045.10.1155/2013/154045355761923401850 Search in Google Scholar

56. Hu XF, Stranges S, Chan LHM. Circulating selenium concentration is inversely associated with the prevalence of stroke: Results from the Canadian Health Measures Survey and the National Health and Nutrition Examination Survey. J Am Heart Assoc. 2019;8(10):e012290.10.1161/JAHA.119.012290658531431084244 Search in Google Scholar

57. Kieliszek M, Lipinski B, Błażejak S. Application of sodium selenite in the prevention and treatment of cancers. Cells. 2017;6(4):39.10.3390/cells6040039575549829064404 Search in Google Scholar

58. Sanmartín C, Plano D, Sharma AK, Palop JA. Selenium compounds, apoptosis and other types of cell death: An overview for cancer therapy. IJMS. 2012;13(8):9649-72.10.3390/ijms13089649343182122949823 Search in Google Scholar

59. Mehdi Y, Hornick JL, Istasse L, Dufrasne I. Selenium in the environment, metabolism and involvement in body functions. Molecules. 2013;18(3):3292-311.10.3390/molecules18033292627013823486107 Search in Google Scholar

60. Natasha, Shahid M, Niazi NK, et al. A critical review of selenium biogeo-chemical behavior in soil-plant system with an inference to human health. Environ Poll. 2018;234:915-34.10.1016/j.envpol.2017.12.01929253832 Search in Google Scholar

61. Kieliszek M. Selenium – fascinating microelement, properties and sources in food. Molecules. 2019;24(7). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480557.]10.3390/molecules24071298648055730987088 Search in Google Scholar

62. He Y, Xiang Y, Zhou Y, et al. Selenium contamination, consequences and remediation techniques in water and soils: A review. Environ Res. 2018;164:288-301.10.1016/j.envres.2018.02.03729554620 Search in Google Scholar

63. Lynam MM, Dvonch JT, Hall NL, et al. Spatial patterns in wet and dry deposition of atmospheric mercury and trace elements in central Illinois, USA. Environ Sci Pollut Res Int. 2014;21(6):4032-43.10.1007/s11356-013-2011-423943079 Search in Google Scholar

64. Burk RF, Hill KE. Regulation of selenium metabolism and transport. Annu Rev Nutr. 2015;35:109-34.10.1146/annurev-nutr-071714-03425025974694 Search in Google Scholar

65. Constantinescu-Aruxandei D, Frîncu R, Capră L, Oancea F. Selenium analysis and speciation in dietary supplements based on next-generation selenium ingredients. Nutrients. 2018;10(10):1466.10.3390/nu10101466621337230304813 Search in Google Scholar

66. Groth S, Budke C, Neugart S, et al. Influence of a selenium biofortification on antioxidant properties and phenolic compounds of apples (Malus domestica). Antioxidants. 2020;9(2):187.10.3390/antiox9020187707092932102431 Search in Google Scholar

67. Schomburg L. The other view: the trace element selenium as a micro-nutrient in thyroid disease, diabetes, and beyond. Hormones (Athens). 2020;19(1):15-24.10.1007/s42000-019-00150-431823341 Search in Google Scholar

68. Rayman MP. Selenium intake, status, and health: a complex relationship. Hormones (Athens). 2020;19(1):9-14.10.1007/s42000-019-00125-5703305731388899 Search in Google Scholar

69. Wojtasik A, Jarosz M, Stoś K. Składniki mineralne. In: M. Jarosz (ed.) Normy żywienia dla populacji Polski. Warszawa: Instytut Żywności i Żywienia; 2017. p. 203-37. Search in Google Scholar

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