1. bookVolume 42 (2021): Issue 2 (October 2021)
Journal Details
License
Format
Journal
First Published
08 Sep 2014
Publication timeframe
2 times per year
Languages
English
access type Open Access

Leptin, Obesity Parameters, and Atopy Among Children with Asthma

Published Online: 26 Oct 2021
Page range: 79 - 88
Journal Details
License
Format
Journal
First Published
08 Sep 2014
Publication timeframe
2 times per year
Languages
English
Abstract

Leptin, as a major adipokine, positively correlates with the body’s fat, while atopy is an important feature in the development of childhood asthma. We aimed to evaluate the relationship between leptin, parameters of obesity, and atopy in children with asthma. The study included 112 children (73 boys, 39 girls, mean age 11.1±2.4). 41 were overweight, 38 had asthma and a normal body mass index (BMI), and 33 were overweight asthmatics. Serum leptin levels, BMI, waist circumference (WC), and waist to hips ratio (WHR) were measured. Skin prick test (SPT)/CAP, total serum IgE, fractional exhaled nitric oxide (FeNO), and pulmonary function tests were performed. In asthmatic children, serum leptin median level was 9.2±16.2 ng/ml, in overweight children was 30.6±21.6 ng/ml, and in overweight asthmatics was 31.1±20.3 ng/ml with a significant difference between the groups (p=0.0374), yet with a significantly lower median level in the group of children with asthma compared to the overweight children: with asthma (p=0.00001) and without asthma (p=0.00001). In the three groups of patients, BMI and WC displayed a significant positive correlation with leptin (for BMI r=0.652 vs. r=0.530 vs. r=0.563, respectively and for WC r=0.508 vs. r=0.426 vs. r=0.527, respectively). No significant correlations of leptin within atopy parameters (Eo, IgE, SPT/CAP, FeNO) in all three analyzed groups (p>0.05) was detected.

Conclusion: Atopy was not confirmed as an underlying mechanism of the association between asthma and being overweight. Leptin had a significant linear correlation as a parameter of central obesity with BMI and WC in all three groups, but not with WHR.

Keywords

1. Masoli M, Fabian D, Holt S, Beasley R. Global Initiative for Asthma (GINA) Program The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004; 59:469–78. Search in Google Scholar

2. Влашки Е., Ставриќ К., Сечкова Л. и сор. Преваленција и тежина на астма, алергиски ринит и егзема кај школските деца во Скопје (Интернационална студија за астма и алергии во детството, фаза 3). Мак Спи Мед 2005; 51(1-2):11-23. Search in Google Scholar

3. Vlaski E, Stavrikj K, Kimovska M, Cvejoska Cholakovska V, Lawson J. Divergent trends in the prevalence of asthma-like symptoms and asthma in a developing country: three repeated surveys between 2002 and 2016. Allergol et Immunopathol (Madr) 2020;48(5):475-83. Search in Google Scholar

4. Vlaski E, Stavric K, Isjanovska R, et al. Over-weight hypothesis in asthma and eczema in young adolescents. Allergol et Immunopathol (Madr) 2006;34(5):199-205. Search in Google Scholar

5. Obesity and overweight. World Heаlth Statistics 2017. WHO Search in Google Scholar

6. Vlashki E. Cvejoska Colakovska V, Kimovska M, et al. Body mass index and risk of asthma and asthma-like symptoms in childhood [abstract]. In: Proceedings of the Annual Congress of the European Academy of Allergology and Clinical Immunology 2017 June 17-21, Helsinki, Finland: EAACI; 2017. Abstract nr 1166. Search in Google Scholar

7. Permaul P, Kanchongkittiphon W, Phipatanakul W. Childhood asthma and obesity-what is the true link? Ann Allergy Asthma Immunol. 2014; 113(3):244-46. Search in Google Scholar

8. Peters L, McKinney JM, Smith B, et al. Impact of obesity in asthma: evidence from a large prospective disease management study. Ann Allergy Asthma Immunol 2011;106:30–35 Search in Google Scholar

9. Ferrante AW Jr. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med 2007;262:408–14 Search in Google Scholar

10. Bruunsgaard H, Pedersen BK. Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am. 2003;23:15-39. Search in Google Scholar

11. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1:1155–1161. Search in Google Scholar

12. Erhardt E, Foraita R, Pigeot I et al. Reference values for leptin, adiponectin in children below the age of 10 based on the IDEFICS cohort. International J Obesity 2014;38:532-538. Search in Google Scholar

13. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child over-weight and obesity worldwide: international survey. BMJ 2000;320:1240-3. Search in Google Scholar

14. Waist Circumference and Waist-Hip Ratio, Report of a WHO Expert Consultation”. WHO 8–11 December 2008. Retrieved March 21, 2012. Search in Google Scholar

15. Peter Schwandt and Gerda-Maria Haas. Waist Circumference in Children and Adolescents from Different Ethnicities. Childhood obesity ISBN 978-953-51-0374-5. 2012;79-94. Search in Google Scholar

16. Yunginger JW. Clinical significance of IgE, In: Middleton E, et al editors. Allergy principles and practice 1988;2:849-60. Search in Google Scholar

17. Hoffman DR. Comparison of methods of performing the radioallergosorbent test: Phadebas, Fada-Nalebuff and Hoffman protocols. Ann Allergy 1980;45:343-6. Search in Google Scholar

18. Bouscquet J, Heinzerling L, Bachert C, et al. Practical guidе to skin prick tests in allergy to aeroallergens. Allergy 2012;67:18-24. Search in Google Scholar

19. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 1995;152(3):1107-36. Search in Google Scholar

20. American Thoracic Society: Guidelines for Methacholine and Exercise Challenge Testing. Am J Respir Crit Care Med 2000;161:309-29. Search in Google Scholar

21. Минов Ј. Спирометрија. Минов Ј. Во: Респираторен систем – функционална дијагностика. Пристоп МК, Скопје 2010,49-81. Search in Google Scholar

22. American Thoracic Society Clinical Practice Guidelines: Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications. Am J Respir Crit Care Med 2011;184:602-15. Search in Google Scholar

23. Flaherman V, Rutherford GW. A meta-analysis of the effect of high weight on asthma. Arch Dis Child 2006; 91: 334–339. Search in Google Scholar

24. Lang JE. Obesity, Nutrition, and Asthma in Children. Pediatric allergy, immunology, and pulmonology. 2012 Jun; 25(2):64–75. Search in Google Scholar

25. Mamun AA, Lawlor DA, Alati R, O’Callaghan MJ, Williams GM,Najman JM. Increasing body mass index from age 5 to 14 years predicts asthma among adolescents: evidence from a birth cohort study. Int J Obesity 2007; 31: 578–583. Search in Google Scholar

26. Gilliland FD, Berhane K, Islam T, et al. Obesity and the risk of newly diagnosed asthma in school-age children. Am J Epidemiol 2003; 158: 406–415. Search in Google Scholar

27. Azizpour et al. Effect of childhood BMI on asthma: a systematic review and meta-analysis of case-control studies.BMC Pediatr 2018;18(1)143. doi:10.1186/s12887-018-1093-z. Search in Google Scholar

28. Scott HA, Gibson PG, Garg ML, Wood LG. Airway inflammation is augmented by obesity and fatty acids in asthma. Eur Respir J 2011;38:594–602. Search in Google Scholar

29. Visness CM, London SJ, Daniels JL, et al. Association of childhood obesity with atopic and nonatopic asthma: results from the National Health and Nutrition Examination Survey 1999–2006. J Asthma 2010;47:822–9. Search in Google Scholar

30. Von Mutius EV, Schwartz J, Neas LM, Dock-ery D, Weis ST. Relation of body mass index to asthma and atopy in children: NHNES Study III. Thorax 2001;56:835-8. Search in Google Scholar

31. Henkin S, Brugge D, Bermudez O et al. A case-control study of body mass index and asthma in Asian children. Ann of Allergy Asthma Immunol. 2008;100:447-451. Search in Google Scholar

32. Papoutsakis C, Chondronikola M, Antonogeorgos G et al. Associations between central obesity and asthma in children and adolescents: a case control study. J Asthma 2015;52(2):128-134. Search in Google Scholar

33. Visness C, London S, Daniels J et al. Association of Obesity with IgE and Allergy Symptoms in Children and Adolescents: Results from NHANES 2005–2006. J Allergy Clin Immunol 2009; 123(5):1163–1169. Search in Google Scholar

34. Baraldi E, de Jongste JC. Measurement of exhaled nitic oxide in children. Eur Respir J 2002;20:223-37. Search in Google Scholar

35. Franklin P, Taplin R, Stick S. A community study of exhaled nitric oxide in healthy children. Am J Respir Crit Care Med 1999;159:69-72. Search in Google Scholar

36. Ferrante AW Jr. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med 2007;262:408–14. Search in Google Scholar

37. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1:1155–1161. Search in Google Scholar

38. Loffreda S, Yang SQ, Lin HZ, et al. Leptin regulates proinflammatory immune responses. FASEB J 1998;12:57–65. Search in Google Scholar

39. Kocova M, Sukarova-Angelovska E, Tanaskoska M et al. Metabolic setup and risks in obese children. J Med Biochem 2015;34(1):31-7 Search in Google Scholar

40. Palchevska S, Krstesvska М, Shukarova Е, et al. Comparing preterm and term newborns serum adiponectin and leptin concentrations and their correlations with anthropometric parameters Macedonian Journal of Medical Sciences 2012;5(3):317-323. Search in Google Scholar

41. Palchevska S, Aluloska N, Krstevska M, et al. Correlation of serum adiponectin and leptin concentrations with anthropometric parameters in newborns. Srpski Archiv za Celokupno Lekarstvo 2012;140(9-10):595-9. Search in Google Scholar

42. Blum WF, Englaro P, Hanitsch S, et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab 1997;82:2904-10. Search in Google Scholar

43. Garcia-Mayor RV, Andrade MA, Rios M, Lage M, Dieguez C, Casanueva FF. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal Search in Google Scholar

44. stage. J Clin Endocrinol Metab 1997;82:2849-55. Search in Google Scholar

45. Lugogo N, Bappanad, Kraft M. Obesity, metabolic dysregulation, and oxidative stress in asthma. Biochem Biophys Acta 2011;1810:1120-1126. Search in Google Scholar

46. Guler N, Kirerleri E, Ones U, et al. Leptin: does it have any role in childhood asthma? J Allergy Clin Immunol 2004:114:254–9. Search in Google Scholar

47. Nagel G, Koenig W, Rapp K, et al. Associations of adipokines with asthma, rhino conjunctivitis, and eczema in German schoolchildren. Pediatric Allergy Immunol 2009; 20: 81–88. Search in Google Scholar

48. Yuksel H, Sogut A, Yilmaxz O et al. Role of adipokines and hormones on obesity in childhood asthma. Allergy Asthma Immunol Res 2012;4(2):98-103. Search in Google Scholar

49. Appleton SL, Adams RJ, Wilson DH, Taylor AW, Ruffin RE; North West Adelaide Health Study Team. Central obesity is associated with nonatopic but not atopic asthma in a representative population sample. J Allergy Clin Immunol 2006;118:1284–1291. Search in Google Scholar

50. Appleton SL, Adams RJ, Wilson DH, et al. Central obesity is associated with nonatopic but not atopic asthma in a representative population sample. J Allergy Clin Immunol 2006;118:1284–1291. Search in Google Scholar

51. Bustos P, Amigo H, Oyarzun M, Rona RJ. Is there a causal relation between obesity and asthma? Evidence from Chile. Int J Obes Relat Metab Disord 2005;29:804-9. Search in Google Scholar

52. Janssen I, Katzmarzyk P, Ross R. Waist circumference and not body mass index explains obesity-related health risk. Am J Clin Nutr 2004;79:379-84. Search in Google Scholar

53. Bronwyn KB, Kull I, Garden F, et al. Breast-feeding, asthma and allergy: a tale of two cities. Pediatr Allergy Immunol 2012; 23: 75-82. Search in Google Scholar

54. Tarrant M, Kwok MK, Lam TH, et al. Breast-feeding and childhood hospitalizations for infections. Epidemiology 2010; 21: 947-54. Search in Google Scholar

55. Gillmann MW, Rifas-Shiman SL, Camargo CA, et al. Risk of overweight among adolescents who were breastfed as infants. JAMA 2001;285:2461-7. Search in Google Scholar

56. Fiocchi AG, Martelli A, De Chiara A, et al. Primary dietary prevention of food allergy. Ann Allergy Asthma Immunol. 2003; 91(1): 3-12. Search in Google Scholar

57. Jwa SC, Fujiwara T, Kondo N. Latent protective effects of breastfeeding on late childhood over-weight and obesity: A nationwide prospective study. J Obes 2014;22:1527–1537. Search in Google Scholar

58. Schellong K, Schulz S, Harder T, Plagemann A. Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally. PloS One 2012; 7: e47776. Search in Google Scholar

59. Oldroyd J, Renzaho A, Skouteris H. Low and high birth weight as risk factors for obesity among 4 to 5-year-old Australian children: does gender matter? Eur J Pediatr 2011;170:899–906. Search in Google Scholar

60. Rugholm S, Baker JL, Olsen LW, et al. Stability of the association between birth weight and childhood overweight during the development of the obesity epidemic. Obes Res 2005; 13: 2187–2194. Search in Google Scholar

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