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  1. bookVolume 49 (2015): Issue 1 (March 2015)
Radiology and Oncology's Cover Image
Radiology and Oncology
Journal Details
License
Format
Journal
First Published
30 Apr 2007
Publication timeframe
4 times per year
Languages
English
access type Open Access

Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer

Maja Sereg-Bahar
Ales Jerin
Irena Hocevar-Boltezar
Published Online: 03 Mar 2015
Page range: 59 - 64
Received: 19 Jan 2014
Accepted: 21 Mar 2014
Journal Details
License
Format
Journal
First Published
30 Apr 2007
Publication timeframe
4 times per year
Languages
English
Abstract

Background. Gastroesophageal reflux is suspected to be an etiological factor in laryngeal and pharyngeal cancer. The aim of this study was to establish, using a non-invasive method, whether laryngopharyngeal reflux (LPR) appears more often in patients with early laryngeal cancer than in a control group.

Patients and methods. We compared the pH, the level of bile acids, the total pepsin and the pepsin enzymatic activity in saliva in a group of 30 patients with T1 laryngeal carcinoma and a group of 34 healthy volunteers.

Results. The groups differed significantly in terms of levels of total pepsin and bile acids in the saliva sample. Higher levels of total pepsin and bile acids were detected in the group of cancer patients. No significant impact of other known factors influencing laryngeal mucosa (e.g. smoking, alcohol consumption, and the presence of irritating substances in the workplace) on the results of saliva analysis was found.

Conclusions. A higher level of typical components of LPR in the saliva of patients with early laryngeal cancer than in the controls suggests the possibility that LPR, especially biliary reflux, has a role in the development of laryngeal carcinoma.

Keywords

  • laryngopharyngeal reflux
  • gastric acid
  • pepsin
  • bile acids
  • laryngeal carcinoma

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