1. bookVolume 27 (2019): Issue 3 (July 2019)
Journal Details
License
Format
Journal
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English
Copyright
© 2020 Sciendo
Journal Details
License
Format
Journal
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English
Copyright
© 2020 Sciendo

Background: Fungal infections are a health issue paradoxically fuelled by the developments in medical care. Objectives: Our study is an investigation on the correlation between the infection site and the genotypes of Candida albicans strains isolated from Romanian patients. Methods: A total number of 301 isolates from different clinical sites were investigated in terms of genotype determination. Results: The isolates were clustered in three groups according to their genotype: 55.81% showed genotype A, 14.62% genotype B, and 29.57% genotype C. Conclusions: No significant correlation was found between the genotype and the infection site, but a significant correlation was found between genotype C and isolates from HIV patients proving that C. albicans pathogenicity probably relies on factors related to the host.

Keywords

1. Brown GD, Denning DW, Gow NAR, Levitz SM, Netea MG, White TC. Hidden Killers: Human Fungal Infections. Sci Transl Med. 2012;4(165):165rv13. DOI: 10.1126/scitranslmed.300440410.1126/scitranslmed.3004404Open DOISearch in Google Scholar

2. Odds FC, Bougnoux ME, Shaw DJ, Bain JM, Davidson AD, Diogo D, Mette DJ, et al. Molecular phylogenetics of Candida albicans. Eukaryotic cell. 2007;6(6):1041-52. DOI: 10.1128/EC.00041-0710.1128/EC.00041-07Open DOISearch in Google Scholar

3. Roșca I, Bostănaru A-C, Minea B, Năstasă V, Gherghel I, Pânzaru C-V, et al. Phenotypic and genotypic variations in Candida albicans isolates from Romanian patients. Rev Română Med Lab. 2018;26(4):405-13. DOI: 10.2478/rrlm-2018-002310.2478/rrlm-2018-0023Open DOISearch in Google Scholar

4. Barros LM, Boriollo MFG, Alves AC, Klein MI, Gonclaves RB, Hofling JF. Genetic diversity and exoenzyme activities of Candida albicans and Candida dubliniensis isolated from the oral cavity of Brazilian periodontal patients. Arch Oral Biol. 2008 Dec;53(12):1172-8. DOI: 10.1016/j.archoralbio.2008.06.003Search in Google Scholar

5. Li W, Yu D, Gao S, Liu J, Chen Z, Zhao W. Role of Candida albicans secreted aspartyl proteinases (Saps) in severe early childhood caries. Int J Mol Sci. 2014 Jun 13;15(6):10766-79. DOI: 10.3390/ijms15061076610.3390/ijms150610766Open DOISearch in Google Scholar

6. Tamura M, Watanabe K, Mikami J, Yazawa K, Nishimura K. Molecular characterization of new clinical isolates of Candida albicans and C. dubliniensis in Japan: analysis reveals a new genotype of C. albicans with group I intron. J Clin Microbiol. 2001 Dec;39(12):4309-15. DOI: 10.1128/JCM.39.12.4309-4315.200110.1128/JCM.39.12.4309-4315.2001Open DOISearch in Google Scholar

7. She XD, Wang XJ, Fu MH, Shen YN, Liu WD. Geno-type comparisons of strains of Candida albicans from patients with cutaneous candidiasis and vaginal candidiasis. Chin Med J (Engl). 2008 Aug 5;121(15):1450-5. DOI: 10.1097/00029330-200808010-0002110.1097/00029330-200808010-00021Open DOISearch in Google Scholar

8. Schaller M, Bein M, Korting HC, Baur S, Hamm G, Monod M, et al. The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium. Infect Immun. 2003 Jun;71(6):3227-34. DOI: 10.1128/IAI.71.6.3227-3234.2003Search in Google Scholar

9. Al-Karaawi ZM, Manfredi M, Waugh ACW, McCullough MJ, Jorge J, Scully C, et al. Characterization of Candida spp. isolated from the oral cavities of patients from diverse clinical settings. Oral Microbiol Immunol. 2002 Feb;17(1):44-9. DOI: 10.1046/j.0902-0055.2001.00081.x10.1046/j.0902-0055.2001.00081.xOpen DOISearch in Google Scholar

10. McCullough MJ, Clemons KV, Stevens DA. Molecular and phenotypic characterization of genotypic Candida albicans subgroups and comparison with Candida dubliniensis and Candida stellatoidea. J Clin Microbiol. 1999;37(2):417-21.Search in Google Scholar

11. Abdulrahim MH, McManus, BA, Fliut SR, Coleman DC. 2016. Genotyping Candida albicans from Candida leukoplakia and non-Candida leukoplakia shows no enrichment of multilocus sequence typing clades but enrichment of ABC genotype C in Candida leukoplakia. PLoS One. 2013;8(9):e73738. DOI: 10.1371/journal.pone.0073738Search in Google Scholar

12. da Silva-Rocha WP, Lemos VL, Svidizisnki TI, Milan EP, Chaves GM. Candida species distribution, genotyping and virulence factors of Candida albicans isolated from the oral cavity of kidney transplant recipients of two geographic regions of Brazil. BMC Oral Health. 2014;14:20. DOI: 10.1186/1472-6831-14-2010.1186/1472-6831-14-20Open DOISearch in Google Scholar

13. Yaseen MM, Abuharfeil NM, Yaseen MM, Shabsoug BM. The role of polymorphonuclear neutrophils during HIV-1 infection. Arch Virol. 2018;163(1):1-21. DOI: 10.1007/s00705-017-3569-910.1007/s00705-017-3569-9Open DOISearch in Google Scholar

Plan your remote conference with Sciendo