1. bookVolume 28 (2011): Issue 2011 (June 2011)
Journal Details
License
Format
Journal
First Published
13 Jan 2009
Publication timeframe
5 times per year
Languages
English
Journal Details
License
Format
Journal
First Published
13 Jan 2009
Publication timeframe
5 times per year
Languages
English

Alpha-actinins are an ancient family of actin-binding proteins that play structural and regulatory roles in cytoskeletal organization. In skeletal muscle, α-actinin-3 protein is an important structural component of the Z disc, where it anchors actin thin filaments, helping to maintain the myofibrillar array. A common nonsense polymorphism in codon 577 of the ACTN3 gene (R577X) results in α-actinin-3 deficiency in XX homozygotes. Based on knowledge about the role of ACTN3 R557X polymorphism in skeletal muscle function, we postulated that the genetic polymorphism of ACTN3 could also improve sprint and power ability.

Keywords

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