1. bookVolume 8 (2018): Issue 2 (April 2018)
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Zeitschrift
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30 Dec 2014
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access type Open Access

Texture and Gene Expression Analysis of the MRI Brain in Detection of Alzheimer’s Disease

Online veröffentlicht: 01 Nov 2017
Seitenbereich: 111 - 120
Eingereicht: 21 Feb 2017
Akzeptiert: 27 Mar 2017
Zeitschriftendaten
License
Format
Zeitschrift
Erstveröffentlichung
30 Dec 2014
Erscheinungsweise
4 Hefte pro Jahr
Sprachen
Englisch

Alzheimer’s disease is a type of dementia that can cause problems with human memory, thinking and behavior. This disease causes cell death and nerve tissue damage in the brain. The brain damage can be detected using brain volume, whole brain form, and genetic testing. In this research, we propose texture analysis of the brain and genomic analysis to detect Alzheimer’s disease. 3D MRI images were chosen to analyze the texture of the brain, and microarray data were chosen to analyze gene expression. We classified Alzheimer’s disease into three types: Alzheimer’s, Mild Cognitive Impairment (MCI), and Normal. In this study, texture analysis was carried out by using the Advanced Local Binary Pattern (ALBP) and the Gray Level Co-occurrence Matrix (GLCM). We also propose the bi-clustering method to analyze microarray data. The experimental results from texture analysis show that ALBP had better performance than GLCM in classification of Alzheimer’s disease. The ALBP method achieved an average value of accuracy of between 75% - 100% for binary classification of the whole brain data. Furthermore, Biclustering method with microarray data shows good performance gene expression, where this information show influence Alzheimer’s disease with total of bi-cluster is 6.

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