1. bookTom 74 (2020): Zeszyt 6 (December 2020)
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Format
Czasopismo
eISSN
2255-890X
Pierwsze wydanie
14 Sep 2008
Częstotliwość wydawania
6 razy w roku
Języki
Angielski
access type Otwarty dostęp

Mental Disorders Following Covid-19 Infection: A Systematic Review of Acute and Long-Term Psychiatric Manifestations and Associated Brain Changes

Data publikacji: 05 Jan 2021
Tom & Zeszyt: Tom 74 (2020) - Zeszyt 6 (December 2020)
Zakres stron: 347 - 357
Otrzymano: 17 Nov 2020
Przyjęty: 27 Nov 2020
Informacje o czasopiśmie
License
Format
Czasopismo
eISSN
2255-890X
Pierwsze wydanie
14 Sep 2008
Częstotliwość wydawania
6 razy w roku
Języki
Angielski
Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory tract, but sometimes also other organs, including the central nervous system (CNS). It is not well understood how the virus affects the CNS and how frequently it happens. Our review provides insight into the occurrence of mental disorders in Corona Virus Disease 2019 (COVID-19) patients. We also collected information about the biological basis of the susceptibility of brain cells to SARS-CoV-2 and its implication to psychiatric manifestations. We included 24 publications in our review, reporting psychiatric manifestations published between 31 December 2019 and 30 July 2020, using the Preferred Reporting Items for Systemic Review and Meta-Analysis statement. Mental disorders occurred in up to one-fifth of patients during the acute phase of the infection. The most common disorders included anxiety-related disorders, mood-spectrum disorders, impaired consciousness, confusion, delirium and psychosis. The onset of psychiatric manifestations is not always preceded by respiratory symptoms, but occurs initially in COVID-19 patients. Long-term manifestations are mainly depression and post-traumatic stress symptoms. The obtained data allow the statement that direct infection of the CNS by SARS-CoV-2 could be responsible for the observed findings. To further investigate long-term psychiatric manifestations, randomised controlled studies must be initiated.

Keywords

Abad, C., Fearday, A., Safdar, N. (2010). Adverse effects of isolation in hospitalised patients: A systematic review. J. Hosp. Infect.,76 (2), 97–102.10.1016/j.jhin.2010.04.027Search in Google Scholar

Ahmed, H., Patel, K., Greenwood, D. C., Halpin, S., Lewthwaite, P., Salawu, A., Eyre, L., Breen, A., O’Connor, R., Jones, A., Sivan, M. (2020). Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: A systematic review and meta-analysis. J. Rehabil. Med.,52 (5), jrm00063.10.2340/16501977-2694Search in Google Scholar

Alam, S. B., Willows, S., Kulka, M., Sandhu, J. K. (2020). Severe acute respiratory syndrome coronavirus-2 may be an underappreciated pathogen of the central nervous system. Eur. J. Neurol.,27 (11), 2348–2360.10.1111/ene.14442Search in Google Scholar

Alhajjaj, A., Abduljaber, T., Alsadeq, Z., Alkhabbaz, F., Alobaidan, H., Saeed, F., Al-Jishi, J., Aljanobi, G. (2020). Psychological and mental health among isolated hospitalized suspected and confirmed COVID-19 patients, Qatif Central Hospital, Eastern Province, Saudi Arabia: A single-center descriptive study. Open J. Int. Med.,10, 245–255.10.4236/ojim.2020.103026Search in Google Scholar

Alkeridy, W. A., Almaghlouth, I., Alrashed, R., Alayed, K., Binkhamis, K., Alsharidi, A., Liu-Ambrose, T. (2020). A unique presentation of delirium in a patient with otherwise asymptomatic COVID-19. J. Amer. Geriatr. Soc.,68 (7), 1382–1384.10.1111/jgs.16536Search in Google Scholar

Amerio, A., Aguglia, A., Odone, A., Gianfredi, V., Serafini, G., Signorelli, C., Amore, M. (2020). Covid-19 pandemic impact on mental health of vulnerable populations. Acta Biomed.,91 (9-s), 95–96.Search in Google Scholar

Anonymous (2020). Worldometers.info. Available from: https://www.worldometers.info/coronavirus/ (accessed 14 October 2020).Search in Google Scholar

Anzalone, N., Castellano, A., Scotti, R., Scandroglio, A. M., Filippi, M., Ciceri, F., Tresoldi, M., Falini, A. (2020). Multifocal laminar cortical brain lesions: A consistent MRI finding in neuro-COVID-19 patients. J. Neurol.,267 (10), 2806–2809.10.1007/s00415-020-09966-2Search in Google Scholar

Bo, H.-X., Li, W., Yang, Y., Wang, Y., Zhang, Q., Cheung, T., Wu, X., Xiang, Y.-T. (2020). Posttraumatic stress symptoms and attitude toward crisis mental health services among clinically stable patients with COVID-19 in China. Psychol. Med., 1–2.Search in Google Scholar

Byrne, A., Zibin, T., O’Croinin, F. (1993). Viral infections and psychiatric illness. Can. J. Psychiatry,38 (9), 631.10.1177/070674379303800920Search in Google Scholar

Cebrian, J., Gonzalez-Martinez, A., Garcia-Blanco, M. J., Celdran-Vivancos, D., Palacios, E. L., Reig-Rosello, G., Casado-Fernandez, L., Vivancos, J., Gago-Veiga, A. B. (2020). Headache and impaired consciousness level associated with SARS-CoV-2 in CSF: A case report. Neurology,95 (6), 266–268.10.1212/WNL.0000000000010213Search in Google Scholar

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J. A., Yu, T., Zhang, X., Zhang, L. (2020). Epidemio-logical and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. The Lancet,395 (10223), 507–513.10.1016/S0140-6736(20)30211-7Search in Google Scholar

Chen, X., Laurent, S., Onur, O. A., Kleineberg, N. N., Fink, G. R., Schweitzer, F., Warnke, C. (2020). A systematic review of neurological symptoms and complications of COVID-19. J. Neurol., 1–11.Search in Google Scholar

Cheng, S. K., Tsang, J. S., Ku, K. H., Wong, C. W., Ng, Y. K. (2004). Psychiatric complications in patients with severe acute respiratory syndrome (SARS) during the acute treatment phase: A series of 10 cases. Brit. J. Psychiatry,184, 359–360.10.1192/bjp.184.4.35915056583Search in Google Scholar

Davis, D. H., Muniz Terrera, G., Keage, H., Rahkonen, T., Oinas, M., Matthews, F. E., Cunningham, C., Polvikoski, T., Sulkava, R., MacLullich, A. M., Brayne, C. (2012). Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study. Brain,135 (Pt 9), 2809–2816.10.1093/brain/aws190343702422879644Search in Google Scholar

Epstein, D., Andrawis, W., Lipsky, A. M., Ziad, H. A., Matan, M. (2020). Anxiety and suicidality in a hospitalized patient with COVID-19 infection. Eur. J. Case Rep. Intern. Med.,7 (5), 001651.10.12890/2020_001651721382232399450Search in Google Scholar

Ferner, R. E., Aronson, J. K. (2020). Chloroquine and hydroxychloroquine in Covid-19. Brit. Med. J.,369, 2369, m1432.10.1136/bmj.m143232269046Search in Google Scholar

Ferrando, S. J., Klepacz, L., Lynch, S., Tavakkoli, M., Dornbush, R., Baharani, R., Smolin, Y., Bartell, A. (2020). COVID-19 psychosis: A potential new neuropsychiatric condition triggered by novel coronavirus infection and the inflammatory response? Psychosomatics,61 (5), 551–555.10.1016/j.psym.2020.05.012723674932593479Search in Google Scholar

Fong, T. G., Tulebaev, S. R., Inouye, S. K. (2009). Delirium in elderly adults: diagnosis, prevention and treatment. Nat. Rev. Neurol., 5 (4), 210–220.10.1038/nrneurol.2009.24306567619347026Search in Google Scholar

Fu, L., Wang, B., Yuan, T., Chen, X., Ao, Y., Fitzpatrick, T., Li, P., Zhou, Y., Lin, Y.-F. et al. (2020). Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis. J. Inf.,80 (6), 656–665.10.1016/j.jinf.2020.03.041715141632283155Search in Google Scholar

Heurich, A., Hofmann-Winkler, H., Gierer, S., Liepold, T., Jahn, O., Pöhlmann, S. (2014). TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. J. Virol.,88 (2), 1293–1307.10.1128/JVI.02202-13391167224227843Search in Google Scholar

Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., Müller, M. A., Drosten, C., Pöhlmann, S. (2020). SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell,181 (2), 271–280.e8.10.1016/j.cell.2020.02.052710262732142651Search in Google Scholar

Hosseini, A. A., Shetty, A. K., Sprigg, N., Auer, D. P., Constantinescu, C. S. (2020). Delirium as a presenting feature in COVID-19: Neuroinvasive infection or autoimmune encephalopathy? Brain Behav. Immun.,88, 68–70.10.1016/j.bbi.2020.06.012728278932531427Search in Google Scholar

Hu, T., Liu, Y., Zhao, M., Zhuang, Q., Xu, L., He, Q. (2020). A comparison of COVID-19, SARS and MERS. Peer J., 8, e9725.10.7717/peerj.9725744308132879801Search in Google Scholar

Huang, Y., Zhou, H., Yang, R., Xu, Y., Feng, X., Gong, P. (2020). Clinical characteristics of 36 non-survivors with COVID-19 in Wuhan, China. medRxiv, 20029009.10.1101/2020.02.27.20029009Search in Google Scholar

Hübscher, A., Isenmann, S. (2016). Delir: Konzepte, Ätiologie und klinisches Management. Fortschr. Neurol. Psychiatr.,84 (4), 233–244 (in German).Search in Google Scholar

Kenna, H. A., Poon, A. W., de los Angeles, C. P., Koran, L. M. (2011). Psychiatric complications of treatment with corticosteroids: Review with case report. Psychiatry Clin. Neurosci.,65 (6), 549–560.10.1111/j.1440-1819.2011.02260.x22003987Search in Google Scholar

Leonardi, M., Padovani, A., McArthur, J. C. (2020). Neurological manifestations associated with COVID-19: A review and a call for action. J. Neurol.,267 (6), 1573–1576.10.1007/s00415-020-09896-z723839232436101Search in Google Scholar

Leung, K. S.-S., Ng, T. T.-L., Wu, A. K.-L., Yau, M. C.-Y., Lao, H.-Y., Choi, M.-P., Tam, K. K.-G., Lee, L.-K., Wong, B. K.-C., Ho, A. Y.-M. et al. (2020). A territory-wide study of early COVID-19 outbreak in Hong Kong community: A clinical, epidemiological and phylogenomic investigation. medRxiv, 20045740.10.1101/2020.03.30.20045740Search in Google Scholar

Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., G¸tzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ,339 (2009), b2700.10.1136/bmj.b2700271467219622552Search in Google Scholar

Lim, S. T., Janaway, B., Costello, H., Trip, S. A., Price, G. (2020). Persistent psychotic symptoms following Covid-19 disease. BJ Psych. Open, 6 (5), e105.Search in Google Scholar

Loades, M. E., Chatburn, E., Higson-Sweeney, N., Reynolds, S., Shafran, R., Brigden, A., Linney, C., McManus, M. N., Borwick, C., Crawley, E. (2020). Rapid systematic review: The impact of social isolation and loneliness on the mental health of children and adolescents in the context of COVID-19. J. Amer. Acad. Child Adolesc. Psychiatry., 59 (11), 1218–1239.e3.10.1016/j.jaac.2020.05.009726779732504808Search in Google Scholar

Lu, Y., Li, X., Geng, D., Mei, N., Wu, P. Y., Huang, C. C., Jia, T., Zhao, Y., Wang, D., Xiao, A., Yin, B. (2020). Cerebral micro-structural changes in COVID-19 patients: An MRI-based 3-month follow-up study. EClin. Med.,25, 100484.10.1016/j.eclinm.2020.100484739695232838240Search in Google Scholar

Majadas, S., Perez, J., Casado-Espada, N. M., Zambrana, A., Bullon, A., Roncero, C. (2020). Case with psychotic disorder as a clinical presentation of COVID-19. Psychiatry Clin. Neurosci.,74 (10), 551–552.10.1111/pcn.13107736176932639089Search in Google Scholar

Mawhinney, J. A., Wilcock, C., Haboubi, H., Roshanzamir, S. (2020). Neurotropism of SARS-CoV-2: COVID-19 presenting with an acute manic episode. Brit. Med. J. Case Rep.,13 (6), e236123.10.1136/bcr-2020-236123729866532540882Search in Google Scholar

McLoughlin, B. C., Miles, A., Webb, T. E., Knopp, P., Eyres, C., Fabbri, A., Humphries, F., Davis, D. (2020). Functional and cognitive outcomes after COVID-19 delirium. Eur. Geriatr. Med.,11 (5), 857–862.10.1007/s41999-020-00353-8735831732666303Search in Google Scholar

Menninger, K. A. (1994). Influenza and schizophrenia. An analysis of post-influenzal “dementia precox” as of 1918, and five years later further studies of the psychiatric aspects of influenza. 1926. Amer. J. Psychiatry,151 (6 Suppl), 182–187.Search in Google Scholar

Nalleballe, K., Reddy Onteddu, S., Sharma, R., Dandu, V., Brown, A., Jasti, M., Yadala, S., Veerapaneni, K., Siddamreddy, S., Avula, A., Kapoor, N., Mudassar, K., Kovvuru, S. (2020). Spectrum of neuropsychiatric manifestations in COVID-19. Brain Behav. Immun.,88, 71–74.10.1016/j.bbi.2020.06.020Search in Google Scholar

Nampoothiri, S., Sauve, F., Ternier, G., Fernandois, D., Coelho, C., Imbernon, M., Deligia, E., Perbet, R., Florent, V., Baroncini, M., Pasquier, F., Trottein, F., Maurage, C.-A., Mattot, V., Giacobini, P., Rasika, S., Prevot, V. (2020). The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis. bioRxiv, 139329.10.1101/2020.06.08.139329Search in Google Scholar

Parra, A., Juanes, A., Losada, C. P., Alvarez-Sesmero, S., Santana, V. D., Marti, I., Urricelqui, J., Rentero, D. (2020). Psychotic symptoms in COVID-19 patients. A retrospective descriptive study. Psychiatry Res.,291, 113254.Search in Google Scholar

Pascual-Goni, E., Fortea, J., Martinez-Domeno, A., Rabella, N., Tecame, M., Gomez-Oliva, C., Querol, L., Gomez-Anson, B. (2020). COVID-19- associated ophthalmoparesis and hypothalamic involvement. Neurol. Neuroimmunol. Neuroinflamm.,7 (5), doi: 10.1212/NXI.0000000000000823.10.1212/NXI.0000000000000823Search in Google Scholar

Paterson, R. W., Brown, R. L., Benjamin, L., Nortley, R., Wiethoff, S., Bharucha, T., Jayaseelan, D. L., Kumar, G., Raftopoulos, R. E., Zambreanu, L. et al. (2020). The emerging spectrum of COVID-19 neurology: Clinical, radiological and laboratory findings. Brain,143 (10), 3104–3120.10.1093/brain/awaa240Search in Google Scholar

Pfefferbaum, B., North, C. S. (2020). Mental health and the Covid-19 pandemic. New Engl. J. Med.,383 (6), 510–512.10.1056/NEJMp2008017Search in Google Scholar

Qi, D., Yan, X., Tang, X., Peng, J., Yu, Q., Feng, L., Yuan, G., Zhang, A., Chen, Y., Yuan, J. et al. (2020). Epidemiological and clinical features of 2019-nCoV acute respiratory disease cases in Chongqing municipality, China: A retrospective, descriptive, multiple-center study. medRxiv, 20029397.10.1101/2020.03.01.20029397Search in Google Scholar

Rabaan, A. A., Al-Ahmed, S. H., Haque, S., Sah, R., Tiwari, R., Malik, Y. S., Dhama, K., Yatoo, M. I., Bonilla-Aldana, D. K., Rodriguez-Morales, A. J. (2020). SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview. Infez. Med.,28 (2), 174–184.Search in Google Scholar

Rai, D., Garg, R. K., Malhotra, H. S., Verma, R., Jain, A., Tiwari, S. C., Singh, M. K. (2014). Acute confusional state/delirium: An etiological and prognostic evaluation. Ann. Indian Acad. Neurol.,17 (1), 30–34.Search in Google Scholar

Rajkumar, R. P. (2020). COVID-19 and mental health: A review of the existing literature. Asian J. Psychiatr.,52, 102066.10.1016/j.ajp.2020.102066Search in Google Scholar

Rogers, J. P., Chesney, E., Oliver, D., Pollak, T. A., McGuire, P., Fusar-Poli, P., Zandi, M. S., Lewis, G., David, A. S. (2020). Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: A systematic review and meta-analysis with comparison to the COVID-19 pandemic. Lancet Psychiatry,7 (7), 611–627.10.1016/S2215-0366(20)30203-0Search in Google Scholar

Salluh, J. I., Wang, H., Schneider, E. B., Nagaraja, N., Yenokyan, G., Damluji, A., Serafim, R. B., Stevens, R. D. (2015). Outcome of delirium in critically ill patients: Systematic review and meta-analysis. BMJ,350, h2538.10.1136/bmj.h2538445492026041151Search in Google Scholar

Sato, K., Mano, T., Iwata, A., Toda, T. (2020). Neuropsychiatric adverse events of chloroquine: A real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database. Biosci Trends,14 (2), 139–143.10.5582/bst.2020.0308232321905Search in Google Scholar

Severance, E. G., Dickerson, F. B., Viscidi, R. P., Bossis, I., Stallings, C. R., Origoni, A. E., Sullens, A., Yolken, R. H. (2011). Coronavirus immuno-reactivity in individuals with a recent onset of psychotic symptoms. Schizophr. Bull.,37 (1), 101–107.10.1093/schbul/sbp052Search in Google Scholar

Singhal, T. (2020). A review of Coronavirus Disease-2019 (COVID-19). Indian J. Pediatr., 87 (4), 281–286.10.1007/s12098-020-03263-6Search in Google Scholar

Song, E., Zhang, C., Israelow, B., Lu-Culligan, A., Prado, A. V., Skriabine, S., Lu, P., Weizman, O.-E., Liu, F., Dai, Y. et al. (2020). Neuroinvasion of SARS-CoV-2 in human and mouse brain. bioRxiv, 169946.10.1101/2020.06.25.169946Search in Google Scholar

Soysal, P., Kara, O. (2020). Delirium as the first clinical presentation of the coronavirus disease 2019 in an older adult. Psychogeriatrics,20 (5), 763–765.10.1111/psyg.12587Search in Google Scholar

Townsend, L., Dyer, A. H., Jones, K., Dunne, J., Kiersey, R., Gaffney, F., Connor, L., Mooney, A., Leavy, D., Ridge, K. et al. (2020). Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. medRxiv, 20164293.10.1371/journal.pone.0240784Search in Google Scholar

Varatharaj, A., Thomas, N., Ellul, M. A., Davies, N. W. S., Pollak, T. A., Tenorio, E. L., Sultan, M., Easton, A., Breen, G., Zandi, M. et al. (2020). Neurological and neuropsychiatric complications of COVID-19 in 153 patients: A UK-wide surveillance study. Lancet Psychiatry,7 (10), 875–882.10.1016/S2215-0366(20)30287-XSearch in Google Scholar

Vindegaard, N., Benros, M. E. (2020). COVID-19 pandemic and mental health consequences: Systematic review of the current evidence. Brain Behav. Immun.,89, 531–542.10.1016/j.bbi.2020.05.048Search in Google Scholar

Wilkins, E. G., Ellis, M. E., Dunbar, E. M., Gibbs, A. (1988). Does isolation of patients with infections induce mental illness? J. Infect.,17 (1), 43–47.10.1016/S0163-4453(88)92308-0Search in Google Scholar

Yachou, Y., El Idrissi, A., Belapasov, V., Ait Benali, S. (2020). Neuro-invasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: Understanding the neurological manifestations in COVID-19 patients. Neurol. Sci.,41, 2657–2669.10.1007/s10072-020-04575-3738520632725449Search in Google Scholar

Zaim, S., Chong, J. H., Sankaranarayanan, V., Harky, A. (2020). COVID-19 and multiorgan response. Curr. Probl. Cardiol.,45 (8), 100618.10.1016/j.cpcardiol.2020.100618718788132439197Search in Google Scholar

Zhang, B., Zhou, X., Qiu, Y., Song, Y., Feng, F., Feng, J., Song, Q., Jia, Q., Wang, J. (2020). Clinical characteristics of 82 cases of death from COVID-19. PLoS One,15 (7), e0235458.10.1371/journal.pone.0235458734713032645044Search in Google Scholar

Zhang, J., Lu, H., Zeng, H., Zhang, S., Du, Q., Jiang, T., Du, B. (2020). The differential psychological distress of populations affected by the COVID-19 pandemic. Brain Behav. Immun.,87, 49–50.10.1016/j.bbi.2020.04.031715694632304883Search in Google Scholar

Zubair, A. S., McAlpine, L. S., Gardin, T., Farhadian, S., Kuruvilla, D. E., Spudich, S. (2020). Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of Coronavirus Disease 2019: A review. JAMA Neurol.,77 (8), 1018–1027.10.1001/jamaneurol.2020.2065748422532469387Search in Google Scholar

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