Postoperative radiotherapy for patients with completely resected pathological stage IIIA-N2 non-small cell lung cancer: a preferential benefit for squamous cell carcinoma
, , , , , , , y | 03 dic 2020
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Article Category: Research Article
Publicado en línea: 03 dic 2020
Páginas: 66 - 76
Recibido: 21 jul 2020
Aceptado: 06 oct 2020
DOI: https://doi.org/10.2478/raon-2020-0070
© 2021 Cuimeng Tian, Guimei Liu, Yongxiang Xu, Guangrong Xia, Tongmei Zhang, Jiaqiang Huang, Hui Jiang, Ji Ming Wang, Baolan Li, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Figure 1
Figure 2
Univariate analyses of the factors affecting overall survival (OS), loco-regional recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) of lung squamous cell carcinoma (LADC) patients (N = 194)
| Characteristics | No. | OS | LRFS | DMFS | |||
|---|---|---|---|---|---|---|---|
| 5-year OS, % | P | 5-year LRFS, % | P | 5-year DMFS, % | P | ||
| 0.071 | 0.085 | 0.139 | |||||
| | 96 | 48.2 | 46.9 | 44.1 | |||
| | 98 | 39.6 | 37.1 | 30.6 | |||
| 0.751 | 0.811 | 0.494 | |||||
| | 139 | 43.6 | 41.6 | 34.5 | |||
| | 55 | 45.0 | 42.8 | 41.3 | |||
| 0.001* | 0.001* | 0.006* | |||||
| | 127 | 50.4 | 49.4 | 44.5 | |||
| | 67 | 31.0 | 27.4 | 22.7 | |||
| 0.468 | 0.158 | 0.319 | |||||
| | 178 | 44.1 | 42.3 | 36.5 | |||
| | 16 | 41.7 | 38.5 | 37.5 | |||
| 0.032* | 0.020* | 0.001* | |||||
| | 166 | 46.3 | 44.0 | 40.4 | |||
| | 28 | 29.5 | 28.0 | 15.5 | |||
| 0.001* | 0.002* | 0.000* | |||||
| | 46 | 60.9 | 58.3 | 58.8 | |||
| | 62 | 37.9 | 38.8 | 37.8 | |||
| | 86 | 38.7 | 35.4 | 22.5 | |||
| 0.000* | 0.000* | 0.000* | |||||
| | 87 | 56.6 | 54.7 | 53.4 | |||
| | 107 | 33.3 | 31.4 | 20.4 | |||
| 0.000* | 0.001* | 0.000* | |||||
| | 80 | 54.8 | 52.7 | 51.8 | |||
| | 114 | 35.7 | 34.0 | 26.9 | |||
| 0.001* | 0.002* | 0.001* | |||||
| | 46 | 60.9 | 58.3 | 58.8 | |||
| | 148 | 38.3 | 36.9 | 29.0 | |||
| 0.169 | 0.280 | 0.541 | |||||
| | 24 | 34.4 | 36.5 | 37.5 | |||
| | 170 | 44.9 | 43.0 | 36.6 | |||
| 0.948 | 0.723 | 0.440 | |||||
| | 152 | 45.0 | 43.0 | 38.8 | |||
| | 42 | 40.0 | 40.0 | 28.7 | |||
Multivariate analyses of the factors affecting overall survival (OS), loco-regional recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) of lung adenocarcinoma (LSCC) patients (N = 85)
| Characteristics | OS | LRFS | DMFS | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR(95% CI) | P | HR (95% CI) | P | |
| 0.789 | 0.823 | 0.563 | ||||
| | 1 | 1 | 1 | |||
| | 0.905(0.436–1.880) | 0.922(0.454–1.874) | 0.806(0.389–1.672) | |||
| 0.208 | 0.149 | 0.151 | ||||
| | 1 | 1 | 1 | |||
| | 1.436(0.817–2.522) | 1.524(0.860–2.701) | 1.522(0.858–2.699) | |||
| 0.257 | 0.296 | 0.664 | ||||
| | 1 | 1 | 1 | |||
| | 1.618(0.704–3.715) | 1.556(0.679–3.563) | 1.194(0.537–2.657) | |||
| 0.440 | 0.454 | 0.330 | ||||
| | 1 | 1 | 1 | |||
| | 1.322(0.650–2.689) | 1.308(0.648–2.643) | 1.428(0.697–2.925) | |||
| 0.922 | 0.963 | 0.813 | ||||
| | 1 | 1 | 1 | |||
| | 1.043(0.447–2.436) | 0.979(0.409–2.343) | 0.903(0.385–2.114) | |||
| 0.127 | 0.224 | 0.496 | ||||
| | 1 | 1 | 1 | |||
| | 0.523(0.227–1.202) | 0.595(0.258–1.374) | 0.751(0.328–1.715) | |||
| 0.017* | 0.006* | 0.013* | ||||
| | 1 | 1 | 1 | |||
| | 0.364(0.159–1.832) | 0.308(0.133–0.712) | 0.349(0.152–0.802) | |||
Univariate analyses of the factors affecting overall survival (OS), loco-regional recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) of lung adenocarcinoma (LSCC) patients (N = 85)
| Characteristics | No | OS | LRFS | DMFS | |||
|---|---|---|---|---|---|---|---|
| 5-year OS, % | P | 5-year LRFS, % | P | 5-year DMFS, % | P | ||
| 0.670 | 0.784 | 0.762 | |||||
| | 7 | 42.9 | 42.9 | 42.9 | |||
| | 78 | 43.2 | 39.1 | 41.3 | |||
| 0.362 | 0.617 | 0.447 | |||||
| | 60 | 46.4 | 40.8 | 43.9 | |||
| | 25 | 36.0 | 36.0 | 36.0 | |||
| 0.713 | 0.659 | 0.767 | |||||
| | 18 | 55.6 | 44.4 | 50.0 | |||
| | 67 | 39.6 | 37.8 | 39.0 | |||
| 0.283 | 0.375 | 0.498 | |||||
| | 57 | 47.6 | 42.4 | 45.5 | |||
| | 28 | 34.1 | 33.2 | 33.9 | |||
| 0.341 | 0.289 | 0.237 | |||||
| | 56 | 46.4 | 44.1 | 47.1 | |||
| | 29 | 37.0 | 30.3 | 31.8 | |||
| 0.625 | 0.596 | 0.882 | |||||
| | 31 | 50.6 | 44.4 | 44.8 | |||
| | 26 | 41.3 | 37.8 | 41.2 | |||
| | 28 | 35.2 | 34.3 | 38.1 | |||
| 0.115 | 0.161 | 0.431 | |||||
| | 45 | 49.2 | 45.2 | 46.1 | |||
| | 40 | 36.7 | 34.1 | 36.1 | |||
| 0.152 | 0.154 | 0.265 | |||||
| | 51 | 48.7 | 43.8 | 46.9 | |||
| | 34 | 34.4 | 33.0 | 33.1 | |||
| 0.367 | 0.363 | 0.654 | |||||
| | 31 | 50.6 | 44.4 | 44.8 | |||
| | 54 | 38.9 | 36.9 | 39.7 | |||
| 0.316 | 0.371 | 0.525 | |||||
| | 13 | 30.8 | 30.8 | 30.8 | |||
| | 72 | 45.3 | 40.9 | 43.5 | |||
| 0.026* | 0.008** | 0.018* | |||||
| | 66 | 37.7 | 32.5 | 35.3 | |||
| | 19 | 63.2 | 63.2 | 63.2 | |||
Multivariate analyses of the factors affecting overall survival (OS), loco-regional recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) of lung squamous cell carcinoma (LADC) patients (N = 194)
| Characteristics | OS | LRFS | DMFS | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR(95% CI) | P | HR (95% CI) | P | |
| 0.000* | 0.000* | 0.005* | ||||
| | 1 | 1 | 1 | |||
| | 2.172(1.471–3.207) | 2.098(1.421–3.099) | 1.739(1.181–2.560) | |||
| 0.074 | 0.156 | 0.002* | ||||
| | 1 | 1 | 1 | |||
| | 1.560(0.958–2.542) | 1.428(0.873–2.337) | 2.120(1.308–3.435) | |||
| 0.255 | 0.234 | 0.134 | ||||
| | 1 | 1 | 1 | |||
| | 1.403(0.783–2.512) | 1.441(0.789–2.632) | 1.624(0.861–3.062) | |||
| 0.392 | 0.435 | 0.471 | ||||
| | 1 | 1 | 1 | |||
| | 1.313(0.704–2.447) | 1.291(0.680–2.452) | 1.283(0.651–2.528) | |||
| 0.015* | 0.046* | 0.141 | ||||
| | 1 | 1 | 1 | |||
| | 2.065(1.148–3.714) | 1.818(1.010–3.272) | 1.565(0.863–2.839) | |||
| 0.004* | 0.031* | 0.047* | ||||
| | 1 | 1 | 1 | |||
| | 0.417(0.230–0.757) | 0.524(0.291–0.942) | 0.554(0.310–0.992) | |||
| 0.759 | 0.737 | 0.444 | ||||
| | 1 | 1 | 1 | |||
| | 1.074(0.680–1.697) | 0.924(0.584–1.463) | 1.196(0.756–1.891) | |||
Patient characteristics
| Characteristic | LADC ( N = 194 ) | LSCC ( N = 85 ) | ||||||
|---|---|---|---|---|---|---|---|---|
| Total, n (%) | Non-PORT, n (%) | PORT, n (%) | P | Total, n (%) | Non-PORT, n (%) | PORT, n (%) | P | |
| 0.262 | 0.593 | |||||||
| | 96(49.5) | 72(47.4) | 24(57.1) | 7(8.2) | 6(9.1) | 1(5.3) | ||
| | 98(50.5) | 80(52.6) | 18(42.9) | 78(91.8) | 60(90.9) | 18(94.7) | ||
| 0.058 | 0.814 | |||||||
| | 139(71.6) | 104(68.4) | 35(83.3) | 60(70.6) | 47(71.2) | 13(68.4) | ||
| | 55(28.4) | 48(31.6) | 7(16.7) | 25(29.4) | 19(28.8) | 6(31.6) | ||
| 0.199 | 0.058 | |||||||
| | 127(65.5) | 96(63.2) | 31(73.8) | 18(21.2) | 11(16.7) | 7(36.8) | ||
| | 67(34.5) | 56(36.8) | 11(26.2) | 67(78.8) | 55(83.3) | 12(63.2) | ||
| 0.028 | 0.211 | |||||||
| | 178(91.8) | 136(89.5) | 42(100) | 57(84.0) | 42(63.6) | 15(78.9) | ||
| | 16(8.2) | 16(10.5) | 0(0.0) | 28(16.0) | 24(36.4) | 4(21.1) | ||
| 0.044 | 0.167 | |||||||
| | 166(85.6) | 126(82.9) | 40(95.2) | 56(65.9) | 46(69.7) | 10(52.6) | ||
| | 28(14.4) | 26(17.1) | 2(4.8) | 29(34.1) | 20(30.3) | 9(47.4) | ||
| 0.228 | 0.989 | |||||||
| | 46(23.7) | 38(25.0) | 8(19.0) | 31(36.5) | 24(36.4) | 7(36.8) | ||
| | 62(32.0) | 44(28.9) | 18(42.9) | 26(30.6) | 20(30.3) | 64(31.6) | ||
| | 86(44.3) | 70(46.1) | 16(38.1) | 28(32.9) | 22(33.3) | 6(31.6) | ||
| 0.090 | 0.581 | |||||||
| | 87(44.8) | 73(48.0) | 14(33.3) | 45(52.9) | 36 (54.5) | 9(47.4) | ||
| | 107(55.2) | 79(52.0) | 28(66.7) | 40(47.1) | 30(45.5) | 10(52.6) | ||
| 0.060 | 0.832 | |||||||
| | 80(41.2) | 68(44.7) | 12(28.6) | 51(60.0) | 40(60.6) | 11(57.9) | ||
| | 114(58.8) | 84(55.3) | 30(71.4) | 34(40.0) | 26(39.4) | 8(42.1) | ||
| 0.422 | 0.970 | |||||||
| | 46(23.7) | 38(25.0) | 8(19.0) | 31(36.5) | 24(36.4) | 7(36.8) | ||
| | 148(76.3) | 114(75.0) | 34(81.0) | 54(63.5) | 42(63.6) | 12(63.2) | ||
| 0.026 | 0.512 | |||||||
| | 24(12.4) | 23(15.1) | 1(2.4) | 13(15.3) | 11(16.7) | 2(10.5) | ||
| | 170(87.6) | 129(84.9) | 41(97.6) | 72(84.7) | 55(83.3) | 17(89.5) | ||