Accès libre

PIWI-interacting RNA (piRNA): a narrative review of its biogenesis, function, and emerging role in lung cancer

Pritha Mukherjee
Pritha Mukherjee
, 
Shamee Bhattacharjee
Shamee Bhattacharjee
 et 
Deba Prasad Mandal
Deba Prasad Mandal
   | 28 févr. 2022
Asian Biomedicine's Cover Image
À propos de cet article
Article précédent
Article suivant
Citez
Article Category: Review
Publié en ligne: 28 févr. 2022
Pages: 3 - 14
DOI: https://doi.org/10.2478/abm-2022-0002
Mots clés
© 2022 Pritha Mukherjee et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

Early discoveries related to PIWI proteins and piRNA. piRNA, PIWI-interacting RNA; PIWI, P-element induced wimpy testis protein.
Early discoveries related to PIWI proteins and piRNA. piRNA, PIWI-interacting RNA; PIWI, P-element induced wimpy testis protein.

Figure 2

Representation of how the present findings for PIWI proteins or piRNA integrate with the emerging hallmarks of cancer in the case of lung cancer. Turquoise represents positively regulated with the hallmark, while red represents negatively regulated with the hallmark. piRNA, PIWI-interacting RNA; P-element induced wimpy testis protein.
Representation of how the present findings for PIWI proteins or piRNA integrate with the emerging hallmarks of cancer in the case of lung cancer. Turquoise represents positively regulated with the hallmark, while red represents negatively regulated with the hallmark. piRNA, PIWI-interacting RNA; P-element induced wimpy testis protein.

Important discoveries of PIWI/piRNA expression in various cancers†

Year PIWI/piRNA Expression Cancer type Role
2005 PIWIL2 Upregulated Testicular seminoma Inhibition of apoptosis and promotion of proliferation via Stat3/Bcl-XL signaling pathway [18]
2006 PIWIL1 Upregulated Human gastric cancer Cell proliferation [19]
2007 PIWIL1 Upregulated Soft tissue sarcoma Stem cell proliferation [20]
2008 PIWIL1 Up/down-regulated Adenocarcinoma Poor prognosis and death [21]
2009 PIWIL1 Presence in cytoplasm Esophageal squamous cell carcinoma Poor prognosis [22]
2010 PIWIL2 Varied Cervical neoplasia Biomarker [23]
2010 PIWIL2 Upregulated Human breast cancers Biomarker [24]
2011 PIWIL1 Upregulated Glioma Tumor progression, poor outcome, and biomarker [25]
2011 piR-651 Upregulated Gastric, colon, lung, and breast cancer Increases cell proliferation [26]
2011 PIWIL1 Upregulated Colorectal cancer Leads to poor overall survival, biomarker [27]
2012 piR-823 Downregulated Gastric cancer Increases cell proliferation [28]
2012 PIWIL2 Upregulated Colon cancer Metastasis [29]
2013 PIWI Upregulated Stage III epithelial ovarian cancer Promotes metastasis, biomarker [30]
2013 piR-932 Upregulated Breast cancer Positive regulator of breast cancer stem cells [31]
2014 PIWIL1 Upregulated Human breast cancer Cell proliferation [32]
2014 piRNA-823 Upregulated Multiple myeloma Regulates angiogenesis [33]
2014 PIWIL1 and PIWIL4 Varied Renal cell carcinoma Related to clinicopathological parameters [34]
2014 PIWIL1 Upregulated Cervical cancer Promotes chemoresistance [35]
2014 PIWIL1 Upregulated Hepatocellular carcinoma Reduces proliferation and migration [36]
2015 piRNA-DQ594040 Downregulated Bladder cancer Promotes cell proliferation, colony formation and functions against apoptosis [37]
2015 piR-021285 Upregulated Breast cancer Epigenetic remodeling [38]
2015 PIWIL2 Upregulated Prostate cancer Metastasis [39]
2015 piR-017061 Downregulated Pancreatic cancer Associated with diseased condition [40]
2015 piR-015551 Downregulated Colorectal cancer Associated with long ncRNA expression [41]
2015 PIWIL1 Downregulated Chronic myeloid leukemia Induces growth and metastasis [42]
2015 PIWIL2 Upregulated Cholangiocarcinoma Involved in shorter survival span and metastasis [43]
2015 piR-57125 Downregulated Renal cell carcinoma Associated with tumor recurrence and metastasis, prognostic biomarker [44]
piR-30924 Upregulated
piR-38756 Upregulated
2015 PIWIL1 Upregulated Type 1 endometrial cancer Tumor progression by downregulating PTEN [45]
2015 PIWIL2 Downregulated Bladder cancer Related to disease specific and progression free survival [46]
2016 PIWIL4 Upregulated Breast cancer Metastasis, antiapoptotic activity and proliferation[47]
2016 FR140858 Differentially expressed Head and neck squamous cell carcinoma Correlated to human papillomavirus infection [48]
2016 piR-598 Upregulated Glioma Induces growth and proliferation [49]
2017 PIWIL3 Upregulated Melanoma Induces metastasis [50]
2017 PIWIL4 Upregulated Retinoblastoma Induces proliferation [51]
2018 piR-5937 Varied Colon cancer Biomarker [52]
piR-28876
2018 piR-8041 Downregulated Glioblastoma Related to tumor growth [53]
2018 PIWIL1 Upregulated Gastric cancer Metastasis [54]
2018 PIWIL1 and PIWIL2 Varied Muscle invasive urothelial bladder cancer Correlation with clinical factors, biomarkers [55]
2018 PIWIL4 Upregulated Human breast cancer Cell motility [56]
2019 piR-823 Upregulated Multiple myeloma Tumor progression [57]
2019 piR-39980 Upregulated Neuroblastoma Tumor progression and drug resistance [58]
2019 piR-36712 Downregulated Breast cancer Chemoresistance and tumor progression [59]
2020 piR-004987 Upregulated Lung cancer Correlated with lung cancer from sputum as compared with normal [60]
piR-020809 Upregulated
piR-023338 Downregulated
piR-011186 Downregulated
2021 piR-hsa-211106 Downregulated Lung cancer Chemoresistance and tumor progression [61]
2021 piR-1008 Upregulated Lung cancer
piR-28231 Upregulated Lung cancer
piR-11256 Upregulated Lung cancer
piR-30636 Upregulated Lung cancer
piR-24143 Upregulated Lung cancer Biomarker lung cancer [62]
piR-6842 Upregulated Lung cancer
piR-8757 Upregulated Lung cancer
piR-15572 Upregulated Lung cancer
piR-5444 Upregulated Lung cancer and serum exosome
piR-26925 Upregulated
eISSN:
1875-855X
Langue:
Anglais
Périodicité:
6 fois par an
Sujets de la revue:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine
RSS Feed de la revue