Cystatin C and cystatin SN as possible soluble tumor markers in malignant uveal melanoma

1Kaliki S, Shields CL. Uveal melanoma: relatively rare but deadly cancer. Eye (Lond) 2017; 31: 241-57. doi: 10.1038/eye.2016.275 Kaliki S Shields CL Uveal melanoma: relatively rare but deadly cancer Eye (Lond) 2017 31 241 57 10.1038/eye.2016.275530646327911450Open DOISearch in Google Scholar

2Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA. The 2018 World Health Organization classification of cutaneous, mucosal, and uveal melanoma: detailed analysis of 9 distinct subtypes defined by their evolutionary pathway. Arch Pathol Lab Med 2020; 144: 500-22. doi: 10.5858/arpa.2019-0561-RA Elder DE Bastian BC Cree IA Massi D Scolyer RA The 2018 World Health Organization classification of cutaneous, mucosal, and uveal melanoma: detailed analysis of 9 distinct subtypes defined by their evolutionary pathway Arch Pathol Lab Med 2020 144 500 22 10.5858/arpa.2019-0561-RA32057276Open DOISearch in Google Scholar

3Sathe S, Sakata M, Beaton AR, Sack RA. Identification, origins and the diurnal role of the principal serine protease inhibitors in human tear fluid. Curr Eye Res 1998; 17: 348-62. doi: 10.1080/02713689808951215 Sathe S Sakata M Beaton AR Sack RA Identification, origins and the diurnal role of the principal serine protease inhibitors in human tear fluid Curr Eye Res 1998 17 348 62 10.1080/027136898089512159561826Open DOISearch in Google Scholar

4Saakyan SV, Tsygankov АY, Moiseeva NI, Karamysheva АF, Garri DD. Assessment of the chemosensitivity of uveal melanoma cells ex vivo Bull Exp Biol Med 2020; 170: 142-7. doi: 10.1007/s10517-020-05020-3 Saakyan SV Tsygankov АY, Moiseeva NI Karamysheva АF, Garri DD Assessment of the chemosensitivity of uveal melanoma cells ex vivo Bull Exp Biol Med 2020 170 142 7 10.1007/s10517-020-05020-333231795Open DOISearch in Google Scholar

5Shah SU, Mashayekhi A, Shields CL, Walia HS, Hubbard GB 3rd, Zhang J, et al. Uveal metastasis from lung cancer: clinical features, treatment, and outcome in 194 patients. Ophthalmology 2014; 121: 352-7. doi: 10.1016/j. ophtha.2013.07.014 Shah SU Mashayekhi A Shields CL Walia HS Hubbard GB 3rd Zhang J et al Uveal metastasis from lung cancer: clinical features, treatment, and outcome in 194 patients Ophthalmology 2014 121 352 7 10.1016/j.ophtha.2013.07.01423988200Open DOISearch in Google Scholar

6Valsecchi ME, Orloff M, Sato R, Chervoneva I, Shields CL, Shields JA, et al. Adjuvant sunitinib in high-risk patients with uveal melanoma: comparison with institutional controls. Ophthalmology 2018; 125: 210-7. doi: 10.1016/j. ophtha.2017.08.017 Valsecchi ME Orloff M Sato R Chervoneva I Shields CL Shields JA et al Adjuvant sunitinib in high-risk patients with uveal melanoma: comparison with institutional controls Ophthalmology 2018 125 210 7 10.1016/j.ophtha.2017.08.01728935400Open DOISearch in Google Scholar

7Spagnolo F, Caltabiano G, Queirolo P. Uveal melanoma. Cancer Treat Rev 2012; 38: 549-53. doi: 10.1016/j.ctrv.2012.01.002 Spagnolo F Caltabiano G Queirolo P Uveal melanoma Cancer Treat Rev 2012 38 549 53 10.1016/j.ctrv.2012.01.00222270078Open DOISearch in Google Scholar

8Luke JJ, Triozzi PL, McKenna KC, Van Meir EG, Gershenwald JE, Bastian BC, et al. Biology of advanced uveal melanoma and next steps for clinical therapeutics. Pigment Cell Melanoma Res 2015; 28: 135-47. doi: 10.1111/ pcmr.12304 Luke JJ Triozzi PL McKenna KC Van Meir EG Gershenwald JE Bastian BC et al Biology of advanced uveal melanoma and next steps for clinical therapeutics Pigment Cell Melanoma Res 2015 28 135 47 10.1111/pcmr.12304432663725113308Open DOISearch in Google Scholar

9Turk V, Stoka V, Turk D. Cystatins: biochemical and structural properties, and medical relevance. Front Biosci 2008; 13: 5406-20. doi: 10.2741/3089 Turk V Stoka V Turk D Cystatins: biochemical and structural properties, and medical relevance Front Biosci 2008 13 5406 20 10.2741/308918508595Open DOISearch in Google Scholar

10Breznik B, Mitrović A, Lah T, Kos J. Cystatins in cancer progression: more than just cathepsin inhibitors. Biochimie 2019; 166: 233-50. doi: 10.1016/j. biochi.2019.05.002 Breznik B Mitrović A Lah T Kos J Cystatins in cancer progression: more than just cathepsin inhibitors Biochimie 2019 166 233 50 10.1016/j.biochi.2019.05.00231071357Open DOISearch in Google Scholar

11Wu H, Du Q, Dai Q, Ge J, Cheng X. Cysteine protease cathepsins in atherosclerotic cardiovascular diseases. J Atheroscler Thromb 2018; 25: 111-23. doi: 10.5551/jat.RV17016 Wu H Du Q Dai Q Ge J Cheng X Cysteine protease cathepsins in atherosclerotic cardiovascular diseases J Atheroscler Thromb 2018 25 111 23 10.5551/jat.RV17016Open DOISearch in Google Scholar

12Wallin H, Bjarnadottir M, Vogel LK, Wassélius J, Ekström U, Abrahamson M. Cystatins – extra- and intracellular cysteine protease inhibitors: high-level secretion and uptake of cystatin C in human neuroblastoma cells. Biochimie 2010; 92: 1625-34. doi: 10.1016/j.biochi.2010.08.011 Wallin H Bjarnadottir M Vogel LK Wassélius J Ekström U Abrahamson M Cystatins – extra- and intracellular cysteine protease inhibitors: high-level secretion and uptake of cystatin C in human neuroblastoma cells Biochimie 2010 92 1625 34 10.1016/j.biochi.2010.08.011Open DOISearch in Google Scholar

13Liu Y, Yao J. Research progress of cystatin SN in cancer. Onco Targets Ther 2019; 12: 3411-9. doi: 10.2147/OTT.S194332 Liu Y Yao J Research progress of cystatin SN in cancer Onco Targets Ther 2019 12 3411 9 10.2147/OTT.S194332Open DOISearch in Google Scholar

14Grubb AO. Cystatin C – properties and use as diagnostic marker. Adv Clin Chem 2000; 35: 63-99. doi: 10.1016/s0065-2423(01)35015-1 Grubb AO Cystatin C – properties and use as diagnostic marker Adv Clin Chem 2000 35 63 99 10.1016/s0065-2423(01)35015-1Open DOISearch in Google Scholar

15Abrahamson M, Alvarez-Fernandez M, Nathanson CM. Cystatins. Biochem Soc Symp 2003; 70: 179-99. doi: 10.1042/bss0700179 Abrahamson M Alvarez-Fernandez M Nathanson CM Cystatins Biochem Soc Symp 2003 70 179 99 10.1042/bss070017914587292Open DOISearch in Google Scholar

16Poteryaeva ON, Falameyeva OV, Korolenko TA, Kaledin VI, Djanayeva SJ, Nowicky JW, et al. Cysteine proteinase inhibitor level in tumor and normal tissues in control and cured mice. Drugs Exp Clin Res 2000; 26: 301-6. PMID: 11345042 Poteryaeva ON Falameyeva OV Korolenko TA Kaledin VI Djanayeva SJ Nowicky JW et al Cysteine proteinase inhibitor level in tumor and normal tissues in control and cured mice Drugs Exp Clin Res 2000 26 301 6 PMID: 11345042Search in Google Scholar

17Keppler D. Towards novel anti-cancer strategies based on cystatin function. Cancer Lett 2006; 235: 159-76. doi: 10.1016/j.canlet.2005.04.001 Keppler D Towards novel anti-cancer strategies based on cystatin function Cancer Lett 2006 235 159 76 10.1016/j.canlet.2005.04.00115893421Open DOISearch in Google Scholar

18Lah TT, Kokalj-Kunovar M, Drobnic-Kosorok M, Babnik J, Golouh R, Vrhovec I, et al. Cystatins and cathepsins in breast carcinoma. Biol Chem Hoppe Seyler 1992; 373: 595-604. doi: 10.1515/bchm3.1992.373.2.595 Lah TT Kokalj-Kunovar M Drobnic-Kosorok M Babnik J Golouh R Vrhovec I et al Cystatins and cathepsins in breast carcinoma Biol Chem Hoppe Seyler 1992 373 595 604 10.1515/bchm3.1992.373.2.5951515089Open DOISearch in Google Scholar

19Cox JL. Cystatins and cancer. Front Biosci (Landmark Ed) 2009; 14: 463-74. doi: 10.2741/3255. PMID: 19273078 Cox JL Cystatins and cancer Front Biosci (Landmark Ed) 2009 14 463 74 10.2741/3255.PMID:19273078Open DOISearch in Google Scholar

20Jakoš T, Pišlar A, Jewett A, Kos J. Cysteine cathepsins in tumor-associated immune cells. Front Immunol 2019; 10: 2037. doi: 10.3389/fimmu.2019.02037 Jakoš T Pišlar A Jewett A Kos J Cysteine cathepsins in tumor-associated immune cells Front Immunol 2019 10 2037 10.3389/fimmu.2019.02037672455531555270Open DOISearch in Google Scholar

21Svechnikova IG, Korolenko TA, Stashko JuF, Kaledin VI, Nikolin VP, Nowicky JW. The influence of Ukrain on the growth of HA-1 tumor in mice: the role of cysteine proteinases as markers of tumor malignancy. Drugs Exp Clin Res 1998; 24: 261-9. PMID: 10190085 Svechnikova IG Korolenko TA Stashko JuF Kaledin VI Nikolin VP Nowicky JW The influence of Ukrain on the growth of HA-1 tumor in mice: the role of cysteine proteinases as markers of tumor malignancy Drugs Exp Clin Res 1998 24 261 9 PMID: 10190085Search in Google Scholar

22Korolenko TA, Cherkanova MS, Gashenko EA, Johnston T. Cystatin C, atherosclerosis and lipid-lowering therapy by statins. In: Cohen JB, Ryseck LP, editors. Cystatins: protease inhibitors, biomarkers and immunomodulators. New York, USA: Nova Science Publishers; 2011. p. 187-204. Korolenko TA Cherkanova MS Gashenko EA Johnston T Cystatin C atherosclerosis and lipid-lowering therapy by statins In: Cohen JB, Ryseck LP, editors. Cystatins: protease inhibitors, biomarkers and immunomodulators. New York, USA: Nova Science Publishers; 2011 p 187–204Search in Google Scholar

23Korolenko TA, Pisareva EE, Filyushina EE, Johnston TP, Machova E. Serum cystatin C and chitotriosidase in acute P-407 induced dyslipidemia: can they serve as potential early biomarkers for atherosclerosis? Exp Toxicol Pathol 2015; 67: 459-66. doi: 10.1016/j.etp.2015.06.003 Korolenko TA Pisareva EE Filyushina EE Johnston TP Machova E Serum cystatin C and chitotriosidase in acute P-407 induced dyslipidemia: can they serve as potential early biomarkers for atherosclerosis? Exp Toxicol Pathol 2015 67 459 66 10.1016/j.etp.2015.06.00326129870Open DOISearch in Google Scholar

24Paraoan L, Gray D, Hiscott P, Garcia-Finana M, Lane B, Damato B, et al. Cathepsin S and its inhibitor cystatin C: imbalance in uveal melanoma. Front Biosci (Landmark Ed.) 2009; 14: 2504-13. doi: 10.2741/3393 Paraoan L Gray D Hiscott P Garcia-Finana M Lane B Damato B et al Cathepsin S and its inhibitor cystatin C: imbalance in uveal melanoma Front Biosci (Landmark Ed.) 2009 14 2504 13 10.2741/339319273215Open DOISearch in Google Scholar

25De Souza GA, Godoy LM, Mann M. Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors. Genome Biol 2006; 7: R72. doi: 10.1186/gb-2006-7-8-R72 De Souza GA Godoy LM Mann M Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors Genome Biol 2006 7 R72 10.1186/gb-2006-7-8-R72177960516901338Open DOISearch in Google Scholar

26Balasubramanian SA, Wasinger VC, Pye DC, Willcox MD. Preliminary identification of differentially expressed tear proteins in keratoconus. Mol Vis 2013; 19: 2124-34. eCollection 2013. PMID: 24194634 Balasubramanian SA Wasinger VC Pye DC Willcox MD Preliminary identification of differentially expressed tear proteins in keratoconus Mol Vis 2013 19 2124 34 eCollection 2013. PMID: 24194634Search in Google Scholar

27Dikovskaya MA, Trunov AN, Chernykh VV, Korolenko TA. Cystatin C and lactoferrin concentrations in biological fluids as possible prognostic factors in eye tumor development. Int J Circumpolar Health 2013; 72(Suppl 1): 21087. doi: 10.3402/ijch.v72i0.21087. eCollection 2013 Dikovskaya MA Trunov AN Chernykh VV Korolenko TA Cystatin C and lactoferrin concentrations in biological fluids as possible prognostic factors in eye tumor development Int J Circumpolar Health 2013 72Suppl 1 21087 10.3402/ijch.v72i0.21087.eCollection2013Open DOISearch in Google Scholar

28Korolenko TA, Tuzikov FV, Cherkanova MS, Johnston TP, Tuzikova NA, Loginova VM, et al. Influence of atorvastatin and carboxymethylated glucan on the serum lipoprotein profile and MMP activity of mice with lipemia induced by poloxamer 407. Can J Physiol Pharmacol 2012; 90: 141-53. doi: 10.1139/y11-118 Korolenko TA Tuzikov FV Cherkanova MS Johnston TP Tuzikova NA Loginova VM et al Influence of atorvastatin and carboxymethylated glucan on the serum lipoprotein profile and MMP activity of mice with lipemia induced by poloxamer 407 Can J Physiol Pharmacol 2012 90 141 53 10.1139/y11-11822320860Open DOISearch in Google Scholar

29Pišlar A, Jewett A, Kos J. Cysteine cathepsins: their biological and molecular significance in cancer stem cells. Semin Cancer Biol 2018; 53: 168-77. doi: 10.1016/j.semcancer.2018.07.010 Pišlar A Jewett A Kos J Cysteine cathepsins: their biological and molecular significance in cancer stem cells Semin Cancer Biol 2018 53 168 77 10.1016/j.semcancer.2018.07.01030063965Open DOISearch in Google Scholar

30Jiang J, Liu HL, Liu ZH, Tan SW, Wu B. Identification of cystatin SN as a novel biomarker for pancreatic cancer. Tumor Biol 2015; 36: 3903-10. doi: 10.1007/s13277-014-3033-3 Jiang J Liu HL Liu ZH Tan SW Wu B Identification of cystatin SN as a novel biomarker for pancreatic cancer Tumor Biol 2015 36 3903 10 10.1007/s13277-014-3033-325577248Open DOISearch in Google Scholar

31Jiang Y, Zhang J, Zhang C, Hong L, Jiang Y, Lu L, et al. The role of cystatin C as a proteosome inhibitor in multiple myeloma. Hematology 2020; 25: 457-63. doi: 10.1080/16078454.2020.1850973 Jiang Y Zhang J Zhang C Hong L Jiang Y Lu L et al The role of cystatin C as a proteosome inhibitor in multiple myeloma Hematology 2020 25 457 63 10.1080/16078454.2020.185097333250014Open DOISearch in Google Scholar

32Leto G, Sepporta MV. The potential of cystatin C as a predictive biomarker in breast cancer. Expert Rev Anticancer Ther 2020; 20: 1049-56. doi: 10.1080/14737140.2020.1829481 Leto G Sepporta MV The potential of cystatin C as a predictive biomarker in breast cancer Expert Rev Anticancer Ther 2020 20 1049 56 10.1080/14737140.2020.182948132990495Open DOISearch in Google Scholar

33Ognibene A, Mannucci E, Caldini A, Terreni A, Brogi M, Bardini G, et al. Cystatin C reference values and aging. Clin Biochem 2006; 39: 658-61. doi: 10.1016/j.clinbiochem.2006.03.017 Ognibene A Mannucci E Caldini A Terreni A Brogi M Bardini G et al Cystatin C reference values and aging Clin Biochem 2006 39 658 61 10.1016/j.clinbiochem.2006.03.01716730690Open DOISearch in Google Scholar

34Odden MC, Tager IB, Gansevoort RT, Bakker SJ, Katz R, Fried LF, et al. Age and cystatin C in healthy adults: a collaborative study. Nephrol Dial Transplant 2010; 25: 463-9. doi: 10.1093/ndt/gfp474 Odden MC Tager IB Gansevoort RT Bakker SJ Katz R Fried LF et al Age and cystatin C in healthy adults: a collaborative study Nephrol Dial Transplant 2010 25 463 9 10.1093/ndt/gfp474290424819749145Open DOISearch in Google Scholar

35Edinga BE, Yakam AT, Nansseu JR, Bilong C, Belinga S, Minkala E, et al. Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population. BMC Clin Pathol 2019; 19: 4. doi: 10.1186/ s12907-019-0086-7 Edinga BE Yakam AT Nansseu JR Bilong C Belinga S Minkala E et al Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population BMC Clin Pathol 2019 19 4 10.1186/s12907-019-0086-7642379630923459Open DOISearch in Google Scholar

36Groesbeck D, Köttgen A, Parekh R, Selvin E, Schwartz GJ, Coresh J, et al. Age, gender, and race effects on cystatin C levels in US adolescents. Clin J Am Soc Nephrol 2008; 3: 1777-85. doi: 10.2215/CJN.00840208 Groesbeck D Köttgen A Parekh R Selvin E Schwartz GJ Coresh J et al Age, gender, and race effects on cystatin C levels in US adolescents Clin J Am Soc Nephrol 2008 3 1777 85 10.2215/CJN.00840208257227918815241Open DOISearch in Google Scholar

37Zou J, Chen Z, Wei X, Chen Z, Fu Y, Yang X, et al. Cystatin C as a potential therapeutic mediator against Parkinson’s disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units. Cell Death Dis 2017; 8: e2854. doi: 10.1038/cddis.2017.240 Zou J Chen Z Wei X Chen Z Fu Y Yang X et al Cystatin C as a potential therapeutic mediator against Parkinson’s disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units Cell Death Dis 2017 8 e2854 10.1038/cddis.2017.240552089928569795Open DOISearch in Google Scholar

38Keppler D, Zhang J, Bihani T, Lin AW. Novel expression of CST1 as candidate senescence marker. J Gerontol A Biol Sci Med Sci 2011; 66: 723-31. doi: 10.1093/gerona/glr033 Keppler D Zhang J Bihani T Lin AW Novel expression of CST1 as candidate senescence marker J Gerontol A Biol Sci Med Sci 2011 66 723 31 10.1093/gerona/glr03321636832Open DOISearch in Google Scholar

39Wang R, Chen Z, Fu Y, Wei X, Liao J, Liu X, et al. Plasma cystatin C and high-density lipoprotein are important biomarkers of Alzheimer’s disease and vascular dementia: a cross-sectional study. Front Aging Neurosci 2017; 9: 26. doi: 10.3389/fnagi.2017.00026 Wang R Chen Z Fu Y Wei X Liao J Liu X et al Plasma cystatin C and high-density lipoprotein are important biomarkers of Alzheimer’s disease and vascular dementia: a cross-sectional study Front Aging Neurosci 2017 9 26 10.3389/fnagi.2017.00026529492128223934Open DOISearch in Google Scholar

40Xu Y, Ding Y, Li X, Wu X. Cystatin C is a disease-associated protein subject to multiple regulation. Immunol Cell Biol 2015; 93: 442-51. doi: 10.1038/ icb.2014.121 Xu Y Ding Y Li X Wu X Cystatin C is a disease-associated protein subject to multiple regulation Immunol Cell Biol 2015 93 442 51 10.1038/icb.2014.121716592925643616Open DOISearch in Google Scholar

41Kos J, Mitrović A, Mirković B. The current stage of cathepsin B inhibitors as potential anticancer agents. Future Med Chem 2014; 6: 1355-71. doi: 10.4155/fmc.14.73 Kos J Mitrović A Mirković B The current stage of cathepsin B inhibitors as potential anticancer agents Future Med Chem 2014 6 1355 71 10.4155/fmc.14.7325163003Open DOISearch in Google Scholar

42Pieragostino D, D’Alessandro M, Di Ioia M, Di Ilio C, Sacchetta P, Del Boccio P. Unraveling the molecular repertoire of tears as a source of biomarkers: beyond ocular diseases. Proteomics Clin Appl 2015; 9: 169-86. doi: 10.1002/ prca.201400084 Pieragostino D D’Alessandro M Di Ioia M Di Ilio C Sacchetta P Del Boccio P Unraveling the molecular repertoire of tears as a source of biomarkers: beyond ocular diseases Proteomics Clin Appl 2015 9 169 86 10.1002/prca.20140008425488355Open DOISearch in Google Scholar

43Huh CG, Håkansson K, Nathanson CM, Thorgeirsson UP, Jonsson N, Grubb A, et al. Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene. Mol Pathol 1999; 52: 332-40. doi: 10.1136/mp.52.6.332 Huh CG Håkansson K Nathanson CM Thorgeirsson UP Jonsson N Grubb A et al Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene Mol Pathol 1999 52 332 40 10.1136/mp.52.6.33239571810748866Open DOISearch in Google Scholar

44Wegiel B, Jiborn T, Abrahamson M, Helczynski L, Otterbein L, Persson JL, et al. Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways. PLoS ONE 2009; 4: e7953. doi: 10.1371/journal.pone.0007953 Wegiel B Jiborn T Abrahamson M Helczynski L Otterbein L Persson JL et al Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways PLoS ONE 2009 4 e7953 10.1371/journal.pone.0007953277651519956729Open DOISearch in Google Scholar

45Hammouda NE, Salah El-Din MA, El-Shishtawy MM, El-Gayar AM. Serum cystatin C as a biomarker in diffuse large B-cell lymphoma. Sci Pharm 2017; 85: 9. doi: 10.3390/scipharm85010009 Hammouda NE Salah El-Din MA El-Shishtawy MM El-Gayar AM Serum cystatin C as a biomarker in diffuse large B-cell lymphoma Sci Pharm 2017 85 9 10.3390/scipharm85010009538814628282874Open DOISearch in Google Scholar

46Cao X, Li Y, Luo RZ, Zhang L, Zhang SL, Zeng J, et al. Expression of cystatin SN significantly correlates with recurrence, metastasis, and survival duration in surgically resected non-small cell lung cancer patients. Sci Rep 2015; 5: 8230. doi: 10.1038/srep08230 Cao X Li Y Luo RZ Zhang L Zhang SL Zeng J et al Expression of cystatin SN significantly correlates with recurrence, metastasis, and survival duration in surgically resected non-small cell lung cancer patients Sci Rep 2015 5 8230 10.1038/srep08230431617225648368Open DOISearch in Google Scholar

47Chen YF, Ma G, Cao X, Luo RZ, He LR, He JH, et al. Overexpression of cystatin SN positively affects survival of patients with surgically resected esophageal squamous cell carcinoma. BMC Surg 2013; 13: 15. doi: 10.1186/1471-248213-15 Chen YF Ma G Cao X Luo RZ He LR He JH et al Overexpression of cystatin SN positively affects survival of patients with surgically resected esophageal squamous cell carcinoma BMC Surg 2013 13 15 10.1186/1471-248213-15Open DOISearch in Google Scholar

48Oh SS, Park S, Lee KW, Madhi H, Park SG, Lee HG, et al. Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation. Cell Death Dis 2017; 8: e2729. doi: 10.1038/cddis.2017.153 Oh SS Park S Lee KW Madhi H Park SG Lee HG et al Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation Cell Death Dis 2017 8 e2729 10.1038/cddis.2017.153547757928383558Open DOISearch in Google Scholar

49Oh BM, Lee SJ, Cho HJ, Park YS, Kim JT, Yoon SR, et al. Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer. Cell Death Dis 2017; 8: e2682. doi: 10.1038/cddis.2017.100 Oh BM Lee SJ Cho HJ Park YS Kim JT Yoon SR et al Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer Cell Death Dis 2017 8 e2682 10.1038/cddis.2017.100538651228300829Open DOISearch in Google Scholar

50Yoneda K, Iida H, Endo H, Hosono K, Akiyama T, Takahashi H, et al. Identification of cystatin SN as a novel tumor marker for colorectal cancer. Int J Oncol 2009; 35: 33-40. doi: 10.3892/ijo_00000310 Yoneda K Iida H Endo H Hosono K Akiyama T Takahashi H et al Identification of cystatin SN as a novel tumor marker for colorectal cancer Int J Oncol 2009 35 33 40 10.3892/ijo_00000310Open DOISearch in Google Scholar

51Cui Y, Sun D, Song R, Zhang S, Liu X, Wang Y, et al. Upregulation of cystatin SN promotes hepatocellular carcinoma progression and predicts a poor prognosis. J Cell Physiol 2019; 234: 22623-34. doi: 10.1002/jcp.28828 Cui Y Sun D Song R Zhang S Liu X Wang Y et al Upregulation of cystatin SN promotes hepatocellular carcinoma progression and predicts a poor prognosis J Cell Physiol 2019 234 22623 34 10.1002/jcp.28828676755831106426Open DOISearch in Google Scholar

52Paraoan L, Hiscott P, Gosden C. Cystatin C in macular and neuronal degenerations: Implications for mechanism(s) of age-related macular degeneration. Vision Research 2010; 50: 737-42. doi: 10.1016/j.visres.2009.10.022 Paraoan L Hiscott P Gosden C Cystatin C in macular and neuronal degenerations: Implications for mechanism(s) of age-related macular degeneration Vision Research 2010 50 737 42 10.1016/j.visres.2009.10.02219917302Open DOISearch in Google Scholar