<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Several isoforms of voltage-gated sodium channels (VGSCs) found in peripheral nerves is associated in the pathogenesis of neuropathic and inflammatory pain. Until now, there are few studies of the distribution of VGSCs in dental pulp and its relationship to dental pain. Objective: Perform literature review to provide update information of VGSCs in dental pulp. Methods: We reviewed and discussed seventy-eight articles listed in MEDLINE (PubMed) database using keywords including “sodium channels” and “dental pain”. They are articles published in English from 1978 to 2010. Results: Although several VGSCs isoforms are distributed in dental pulp, only NaV1.7, NaV1.8, and NaV1.9 have been found to be upregulated in painful pulpitis. Conclusion: NaV1.7, NaV1.8, and NaV1.9 seem to have key roles in inflammatory dental pain. As a result, they might be the targets to treat dental pulp inflammation.</abstract>

Background: Several isoforms of voltage-gated sodium channels (VGSCs) found in peripheral nerves is associated in the pathogenesis of neuropathic and inflammatory pain. Until now, there are few studies of the distribution of VGSCs in dental pulp and its relationship to dental pain. Objective: Perform literature review to provide update information of VGSCs in dental pulp. Methods: We reviewed and discussed seventy-eight articles listed in MEDLINE (PubMed) database using keywords including “sodium channels” and “dental pain”. They are articles published in English from 1978 to 2010. Results: Although several VGSCs isoforms are distributed in dental pulp, only NaV1.7, NaV1.8, and NaV1.9 have been found to be upregulated in painful pulpitis. Conclusion: NaV1.7, NaV1.8, and NaV1.9 seem to have key roles in inflammatory dental pain. As a result, they might be the targets to treat dental pulp inflammation.

Expression of sodium channels in dental pulp

Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200,

Cardiac Electrophysiology Research and Training Center, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200,

Cardiac Electrophysiology Research and Training Center, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand

DDS, PhD, Department of Oral Biology and Diagnostic Science, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Expression of sodium channels in dental pulp"}

Background: Several isoforms of voltage-gated sodium channels (VGSCs) found in peripheral nerves is associated in the pathogenesis of neuropathic and...

Expression of sodium channels in dental pulp

Article Category: Review article

Publié en ligne: 04 févr. 2017

Pages: 735 - 746

DOI: https://doi.org/10.5372/1905-7415.0506.100

Mots clés
Dental pulp, expression, inflammation, sodium channels

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Expression of sodium channels in dental pulp

Article Category: Review article

Publié en ligne: 04 févr. 2017

Pages: 735 - 746

DOI: https://doi.org/10.5372/1905-7415.0506.100

Mots clésDental pulp, expression, inflammation, sodium channels

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
Dental pulp, expression, inflammation, sodium channels