<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jccm-2022-0010_s_006">
<h3>Background</h3>
<p>Renal involvement in COVID-19 leads to severe disease and higher mortality. We study renal parameters in COVID-19 patients and their association with mortality and length of stay in hospital.</p>
</sec>
<sec id="j_jccm-2022-0010_s_007">
<h3>Methods</h3>
<p>A retrospective study (n=340) of confirmed COVID-19 patients with renal involvement determined by the presence of acute kidney injury. Multivariate analyses of logistic regression for mortality and linear regression for length of stay (LOS) adjusted for relevant demographic, comorbidity, disease severity, and treatment covariates.</p></sec>
<sec id="j_jccm-2022-0010_s_008">
<h3>Results</h3>
<p>Mortality was 54.4% and mean LOS was 12.9 days. For mortality, creatinine peak (OR:35.27, 95% CI:2.81, 442.06, p&lt;0.01) and persistent renal involvement at discharge (OR:4.47, 95% CI:1.99,10.06, p&lt;0.001) were each significantly associated with increased odds for mortality. Increased blood urea nitrogen peak (OR:0.98, 95%CI:0.97,0.996, p&lt;0.05) was significantly associated with decreased odds for mortality. For LOS, increased blood urea nitrogen peak (B:0.001, SE:&lt;0.001, p&lt;0.01), renal replacement therapy (B:0.19, SE:0.06, p&lt;0.01), and increased days to acute kidney injury (B:0.19, SE:0.05, p&lt;0.001) were each significantly associated with increased length of stay.</p></sec>
<sec id="j_jccm-2022-0010_s_009">
<h3>Conclusion</h3>
<p>Our study emphasizes the importance in identifying renal involvement parameters in COVID-19 patients. These parameters are associated with LOS and mortality, and may assist clinicians to prognosticate COVID-19 patients with renal involvement.</p></sec>
</abstract>

Background
Renal involvement in COVID-19 leads to severe disease and higher mortality. We study renal parameters in COVID-19 patients and their association with mortality and length of stay in hospital.


Methods
A retrospective study (n=340) of confirmed COVID-19 patients with renal involvement determined by the presence of acute kidney injury. Multivariate analyses of logistic regression for mortality and linear regression for length of stay (LOS) adjusted for relevant demographic, comorbidity, disease severity, and treatment covariates.

Results
Mortality was 54.4% and mean LOS was 12.9 days. For mortality, creatinine peak (OR:35.27, 95% CI:2.81, 442.06, p<0.01) and persistent renal involvement at discharge (OR:4.47, 95% CI:1.99,10.06, p<0.001) were each significantly associated with increased odds for mortality. Increased blood urea nitrogen peak (OR:0.98, 95%CI:0.97,0.996, p<0.05) was significantly associated with decreased odds for mortality. For LOS, increased blood urea nitrogen peak (B:0.001, SE:<0.001, p<0.01), renal replacement therapy (B:0.19, SE:0.06, p<0.01), and increased days to acute kidney injury (B:0.19, SE:0.05, p<0.001) were each significantly associated with increased length of stay.

Conclusion
Our study emphasizes the importance in identifying renal involvement parameters in COVID-19 patients. These parameters are associated with LOS and mortality, and may assist clinicians to prognosticate COVID-19 patients with renal involvement.

Renal Manifestations and their Association with Mortality and Length of Stay in COVID-19 Patients at a Safety-net Hospital

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background
Renal involvement in COVID-19 leads to severe disease and higher mortality. We study renal parameters in COVID-19 patients and their association...

Renal Manifestations and their Association with Mortality and Length of Stay in COVID-19 Patients at a Safety-net Hospital

Article Category: Research Article

Pubblicato online: 12 mag 2022

Pagine: 80 - 88

Ricevuto: 20 dic 2021

Accettato: 27 apr 2022

DOI: https://doi.org/10.2478/jccm-2022-0010

Parole chiave
acute kidney injury, COVID-19, length of stay, mortality, SARS-CoV-2

© 2022 Sandra Gomez-Paz, Eric Lam, Luis Gonzalez-Mosquera, Diana Cardenas-Maldonado, Joshua Fogel, Ellen Gabrielle Kagan, Sofia Rubinstein, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Renal Manifestations and their Association with Mortality and Length of Stay in COVID-19 Patients at a Safety-net Hospital

Article Category: Research Article

Pubblicato online: 12 mag 2022

Pagine: 80 - 88

Ricevuto: 20 dic 2021

Accettato: 27 apr 2022

DOI: https://doi.org/10.2478/jccm-2022-0010

Parole chiaveacute kidney injury, COVID-19, length of stay, mortality, SARS-CoV-2

© 2022 Sandra Gomez-Paz, Eric Lam, Luis Gonzalez-Mosquera, Diana Cardenas-Maldonado, Joshua Fogel, Ellen Gabrielle Kagan, Sofia Rubinstein, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Parole chiave
acute kidney injury, COVID-19, length of stay, mortality, SARS-CoV-2