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Low bone mineral density in Thai children with systemic lupus erythematosus: prevalence and risk factors


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Figure 1

The difference in BMD z scores between the first and the follow-up DXA of the hip and lumbar spine. Hip 1, first DXA scan of the hip; Hip 2, follow-up DXA scan of the hip; LS 1, first DXA scan of the lumbar spine; LS 2, follow-up DXA scan of the lumbar spine. Wilcoxon signed-rank test; *P < 0.05, ***P < 0.001. BMD, bone mineral density; DXA, dual-energy X-ray absorptiometry.
The difference in BMD z scores between the first and the follow-up DXA of the hip and lumbar spine. Hip 1, first DXA scan of the hip; Hip 2, follow-up DXA scan of the hip; LS 1, first DXA scan of the lumbar spine; LS 2, follow-up DXA scan of the lumbar spine. Wilcoxon signed-rank test; *P < 0.05, ***P < 0.001. BMD, bone mineral density; DXA, dual-energy X-ray absorptiometry.

Characteristics based on the BMD z score in pediatric patients with SLE

Characteristic First DXA (n = 60) Follow-up DXA (n = 51)

BMD z score P BMD z score P


> −2 (n = 36) ≤−2 (n = 24) >−2 (n = 23) ≤−2 (n = 28)
Age at time of DXA (years), mean (SD) 11.34 (2.42) 11.32 (2.72) 0.98 10.62 (2.67) 11.38 (2.05) 0.28
Disease duration (months), median (IQR) 13.5 (7–21) 17 (8.5–32.5) 0.39 26 (22–37) 40.5 (20.5–53.5) 0.31
Weight for age z score, mean (SD) 1.05 (1.64) –0.12 (1.78) 0.014* 0.92 (1.98) 0.16 (1.56) 0.15
Height for age z score, mean (SD) –0.58 (1.46) –1.00 (1.01) 0.24 –0.58 (1.07) –0.92 (1.19) 0.32
SLEDAI score at DXA, mean (SD) 5.21 (5.73) 6.29 (4.94) 0.48 4.25 (2.90) 5.89 (4.24) 0.25
C3 level, mean (SD) 89.31 (29.30) 88.11 (36.16) 0.89 93.40 (21.10) 99.31 (28.10) 0.40
Vitamin D level, median (IQR) 20 (8–29) 30.50 (13.5–60) 0.26 24.5 (19.6–33.1) 20.1 (13.3–29.2) 0.41
Cumulative corticosteroid dose (g), mean (SD) 11.70 (7.00) 17.38 (13.58) 0.10 15.91 (6.19) 23.65 (14.62) 0.059
Immunosuppressant, n (%) 25 (69.4) 17 (70.8) 0.53§ 18 (78.3) 23 (82.1) 0.73§
Vitamin D supplement, n (%) 17 (47.2) 10 (41.7) 0.53§ 13 (56.5) 20 (71.4) 0.61§
Calcium supplement, n (%) 19 (52.8) 7 (29.2) 0.16§ 18 (78.3) 17 (60.7) 0.64§

Factors associated with low BMD in patients with childhood SLE

Characteristic First DXA Follow-up DXA


Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
OR (95% CI) P Adjusted OR (95% CI) P OR (95% CI) P Adjusted OR (95% CI) P
Weight for age z score 0.67 (0.45–0.93) 0.03 0.78 (0.50–1.17) 0.25 0.87 (0.62–1.20) 0.394
Cumulative steroid dose 1.06 (0.99–1.13) 0.10 1.00 (1.00–1.00) 0.10 1.07 (0.99–1.16) 0.059 1.08 (1.00–1.17) 0.050
eISSN:
1875-855X
Język:
Angielski
Częstotliwość wydawania:
6 razy w roku
Dziedziny czasopisma:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine