<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background.</bold> Parathyroid adenomas, the most common cause of primary hyperparathyroidism, are benign tumours which autonomously produce and secrete parathyroid hormone. [18F]-fluorocholine (FCH), PET marker of cellular proliferation, was recently demonstrated to accumulate in lesions representing enlarged parathyroid tissue; however, the optimal time to perform FCH PET/CT after FCH administration is not known. The aim of this study was to determine the optimal scan time of FCH PET/CT in patients with primary hyperparathyroidism.<bold>Patients and methods.</bold> 43 patients with primary hyperparathyroidism were enrolled in this study. A triple-phase PET/CT imaging was performed five minutes, one and two hours after the administration of FCH. Regions of interest (ROI) were placed in lesions representing enlarged parathyroid tissue and thyroid tissue. Standardized uptake value (SUVmean), retention index and lesion contrast for parathyroid and thyroid tissue were calculated.<bold>Results.</bold> Accumulation of FCH was higher in lesions representing enlarged parathyroid tissue in comparison to the thyroid tissue with significantly higher SUVmean in the second and in the third phase (p &lt; 0.0001). Average retention index decreased significantly between the first and the second phase and increased significantly between the second and the third phase in lesions representing enlarged parathyroid tissue and decreased significantly over all three phases in thyroid tissue (p&lt; 0.0001). The lesion contrast of lesions representing enlarged parathyroid tissue and thyroid tissue was significantly better in the second and the third phase compared to the first phase (p &lt; 0.05).<bold>Conclusions.</bold> According to the results the optimal scan time of FCH PET/CT for localization of lesions representing enlarged parathyroid tissue is one hour after administration of the FCH.</abstract>

Background. Parathyroid adenomas, the most common cause of primary hyperparathyroidism, are benign tumours which autonomously produce and secrete parathyroid hormone. [18F]-fluorocholine (FCH), PET marker of cellular proliferation, was recently demonstrated to accumulate in lesions representing enlarged parathyroid tissue; however, the optimal time to perform FCH PET/CT after FCH administration is not known. The aim of this study was to determine the optimal scan time of FCH PET/CT in patients with primary hyperparathyroidism.Patients and methods. 43 patients with primary hyperparathyroidism were enrolled in this study. A triple-phase PET/CT imaging was performed five minutes, one and two hours after the administration of FCH. Regions of interest (ROI) were placed in lesions representing enlarged parathyroid tissue and thyroid tissue. Standardized uptake value (SUVmean), retention index and lesion contrast for parathyroid and thyroid tissue were calculated.Results. Accumulation of FCH was higher in lesions representing enlarged parathyroid tissue in comparison to the thyroid tissue with significantly higher SUVmean in the second and in the third phase (p < 0.0001). Average retention index decreased significantly between the first and the second phase and increased significantly between the second and the third phase in lesions representing enlarged parathyroid tissue and decreased significantly over all three phases in thyroid tissue (p< 0.0001). The lesion contrast of lesions representing enlarged parathyroid tissue and thyroid tissue was significantly better in the second and the third phase compared to the first phase (p < 0.05).Conclusions. According to the results the optimal scan time of FCH PET/CT for localization of lesions representing enlarged parathyroid tissue is one hour after administration of the FCH.

Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CT

Department for Nuclear Medicine, University Medical Centre Ljubljana, Slovenia

Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Slovenia

Jozef Stefan Institute, Ljubljana, Slovenia

Department of Oncological Surgery, Institute of Oncology Ljubljana, Ljubljana, Slovenia

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Optimal scan time for evaluation of parathyroid adenoma with [F]-fluorocholine PET/CT

Background. Parathyroid adenomas, the most common cause of primary hyperparathyroidism, are benign tumours which autonomously produce and secrete parathyroid...

Optimal scan time for evaluation of parathyroid adenoma with [¹⁸F]-fluorocholine PET/CT

Published Online: Nov 27, 2015

Page range: 327 - 333

Received: Jan 06, 2015

Accepted: Mar 31, 2015

DOI: https://doi.org/10.1515/raon-2015-0016

Keywords
[F]-fluorocholine PET/CT, lesions representing enlarged parathyroid tissue, triple-phase, standardized up-take value, retention index, lesion contrast

© 2015 Sebastijan Rep et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CT

Published Online: Nov 27, 2015

Page range: 327 - 333

Received: Jan 06, 2015

Accepted: Mar 31, 2015

DOI: https://doi.org/10.1515/raon-2015-0016

Keywords[F]-fluorocholine PET/CT, lesions representing enlarged parathyroid tissue, triple-phase, standardized up-take value, retention index, lesion contrast

© 2015 Sebastijan Rep et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Optimal scan time for evaluation of parathyroid adenoma with [¹⁸F]-fluorocholine PET/CT

Keywords
[F]-fluorocholine PET/CT, lesions representing enlarged parathyroid tissue, triple-phase, standardized up-take value, retention index, lesion contrast