High skeletal titanium content, open mesoporous TS-1 titanosilica molecular sieves with more accessible active centres exhibit higher catalytic activity, target product selectivity and resistance to coking deactivation in green catalytic oxidation reactions using hydrogen peroxide as oxidant. In this paper, TS-1 titania-silica molecular sieves without anatase, with the highest theoretical skeletal titanium content (2.0 wt%) and open mesopores (mesopore volume 0.71 cm3/g) were synthesised based on the ageing dry gel limited domain conversion method invented in previous research work. The intrinsic kinetics of the catalytic reaction of phenol with hydrogen peroxide for direct hydroxylation of benzenes was investigated. The effects of stirring rate, phenol concentration, hydrogen peroxide concentration, catalyst dosage and reaction temperature on the initial conversion rate of phenol were investigated, and the experimental data were fitted with a power function equation to obtain the intrinsic kinetic equation of the catalyst