[
Bhaskar S., Sudhakaran P.R., Helen A. (2016). Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-kappaB signaling pathway. Cell. Immunol., 310: 131–140.
]Search in Google Scholar
[
Burmańczuk A., Hola P., Milczak A., Piech T., Kowalski C., Wojciechowska B., Grabowski T. (2018). Quercetin decrease somatic cells count in mastitis of dairy cows. Res. Vet. Sci., 117: 255–259.
]Search in Google Scholar
[
Caglayan Sozmen S., Karaman M., Cilaker Micili S., Isik S., Bagriyanik A., Arikan Ayyildiz Z., Uzuner N., Anal O., Karama n O. (2016). Effects of quercetin treatment on epithelium-derived cytokines and epithelial cell apoptosis in allergic airway inflammation mice model. Iran. J. Allergy. Asthma. Immunol., 15: 487–497.
]Search in Google Scholar
[
Chen S., Ruan Q., Bedner E., Deptala A., Wang X., Hsieh T.C., Traganos F., Darzynkiewicz Z. (2001). Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines. Cell. Prolif., 34: 293–304.
]Search in Google Scholar
[
Chen S., Jiang H., Wu X., Fang J. (2016). Therapeutic effects of quercetin on inflammation, obesity, and type 2 diabetes. Mediat. Inflamm., 2016: ID 9340637.
]Search in Google Scholar
[
Chen Y., Yang Y., Wang F., Yang X., Yao F., Ming K., Yuan W., Zeng L., Liu J. (2018). Antiviral effect of baicalin phospholipid complex against duck hepatitis A virus type 1. Poultry Sci., 97: 2722–2732.
]Search in Google Scholar
[
de Rijke E., Out P., Niessen W.M., Ariese F., Gooijer C., Brinkman U.A. (2006). Analytical separation and detection methods for flavonoids. J. Chromatogr. A., 1112: 31–63.
]Search in Google Scholar
[
EMA (2011). Guideline on bioanalytical method validation. EMEA/CHMP/EWP/192217/2009 Rev. 1 Corr. 2**. 1–23. www.ema.europa.eu/en/documents/scientific-guideline/guideline-bioanalytical-method-validation_en.pdf
]Search in Google Scholar
[
FDA (2018). Bioanalytical Method Validation Guidance for Industry. 1–44. www.fda.gov/files/drugs/published/Bioanalytical-Method-Validation-Guidance-for-Industry.pdf
]Search in Google Scholar
[
Gao X., Guo M., Zhang Z., Shen P., Yang Z., Zhang N. (2017). Baicalin promotes the bacteriostatic activity of lysozyme on S. aureus in mammary glands and neutrophilic granulocytes in mice. Oncotarget, 8: 19894–19901.
]Search in Google Scholar
[
Guo M., Zhang N., Li D., Liang D., Liu Z., Li F., Fu Y., Cao Y., Deng X., Yang Z. (2013). Baicalin plays an anti-inflammatory role through reducing nuclear factor-kappaB and p38 phosphorylation in S. aureus-induced mastitis. Int. Immunopharmacol., 16: 125–130.
]Search in Google Scholar
[
Guo M., Cao Y., Wang T., Song X., Liu Z., Zhou E., Deng X., Zhang N., Yang Z. (2014). Baicalin inhibits Staphylococcus aureus-induced apoptosis by regulating TLR2 and TLR2-related apoptotic factors in the mouse mammary glands. Eur. J. Pharmacol., 723: 481–488.
]Search in Google Scholar
[
He X., We i Z., Zhou E., Chen L., Kou J., Wang J., Yang Z. (2015). Baicalein attenuates inflammatory responses by suppressing TLR4 mediated NF-kappaB and MAPK signaling pathways in LPS-induced mastitis in mice. Int. Immunopharmacol., 28: 470–476.
]Search in Google Scholar
[
Ji B., Zhao X., Yu P., Meng L., Zhao Y., Yu Z. (2017). Simultaneous determination and pharmacokinetics of fourteen bioactive compounds in rat plasma by LC-ESI-MS/MS following intravenous injection of Gegen-Sanqi compatibility solution. J. Chromatogr. B. Analyt. Technol. Biomed. Life. Sci., 1068–1069: 164–172.
]Search in Google Scholar
[
Li C., Lin G., Zuo Z. (2011). Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. Biopharm. Drug. Dispos., 32: 427–445.
]Search in Google Scholar
[
Li-Weber M. (2009). New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer. Treat. Rev., 35: 57–68.
]Search in Google Scholar
[
Lu C.M., Lin L.C., Tsai T.H. (2014). Determination and pharmacokinetic study of gentiopicroside, geniposide, baicalin, and swertiamarin in Chinese herbal formulae after oral administration in rats by LC-MS/MS. Molecules, 19: 21560–21578.
]Search in Google Scholar
[
Ma Z., Otsuyama K., Liu S., Abroun S., Ishikawa H., Tsuyama N., Obata M., Li F.J., Zheng X., Maki Y., Miyamoto K., Kawano M.M. (2005). Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Blood, 105: 3312–3318.
]Search in Google Scholar
[
Maurya A.K., Vinayak M. (2017). Quercetin attenuates cell survival, inflammation, and angio-genesis via modulation of AKT signaling in murine T-cell lymphoma. Nutr. Cancer., 69: 470–480.
]Search in Google Scholar
[
Meng L., Lv Z., Yu Z.Z., Xu D., Ya n X. (2016). Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression. Genet. Mol. Res., 15: gmr7265.
]Search in Google Scholar
[
Muthian G., Bright J.J. (2004). Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte. J. Clin. Immunol., 24: 542–552.
]Search in Google Scholar
[
Oo A., Teoh B.T., Sam S.S., Bakar S.A., Zandi K. (2019). Baicalein and baicalin as Zika virus inhibitors. Arch. Virol., 164: 585–593.
]Search in Google Scholar
[
Perruchot M.H., Gondret F., Robert F., Dupuis E., Quesnel H., Dessauge F. (2019). Effect of the flavonoid baicalin on the proliferative capacity of bovine mammary cells and their ability to regulate oxidative stress. Peer J., doi:10.7717/peerj.656510.7717/peerj.6565640750230863682
]Search in Google Scholar
[
Schapoval E.E., Vargas M.R., Chaves G., Bridi R., Zuanazzi J.A., Henriques A.T. (1998). Antiinflammatory and antinociceptive activities of extracts and isolated compounds from Stachytarpheta cayennensis. J. Ethnopharmacol., 60: 53–59.
]Search in Google Scholar
[
Shen Y.C., Chiou W.F., Chou Y.C., Chen C.F. (2003). Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes. Eur. J. Pharmacol., 465: 171–181.
]Search in Google Scholar
[
Shieh D.E., Cheng H.Y., Ye n M.H., Chiang L.C., Lin C.C. (2006). Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. Am. J. Chinese. Med., 34: 245–261.
]Search in Google Scholar
[
Wang Y., Ya o Y., An R., Yo u L., Wang X. (2009). Simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin of GegenQinlian decoction in rat plasma by ultra-performance liquid chromatography-mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 877: 1820–1826.
]Search in Google Scholar
[
Wu S.C., Chu X.L., Su J.Q., Cui Z.Q., Zhang L.Y., Yu Z.J., Wu Z.M., Cai M.L., Li H.X., Zhang Z.J. (2018). Baicalin protects mice against Salmonella typhimurium infection via the modulation of both bacterial virulence and host response. Phytomedicine, 48: 21–31.
]Search in Google Scholar
[
Yang W., Li H., Cong X., Wang X., Jiang Z., Zhang Q., Qi X., Gao S., Cao R., Tian W. (2016). Baicalin attenuates lipopolysaccharide induced inflammation and apoptosis of cow mam-mary epithelial cells by regulating NF-kappaB and HSP72. Int. Immunopharmacol., 40: 139–145.
]Search in Google Scholar
[
Zhao Q.Y., Yuan F.W., Liang T., Liang X.C., Luo Y.R., Jiang M., Qing S.Z., Zhang W.M. (2018). Baicalin inhibits Escherichia coli isolates in bovine mastitic milk and reduces antimicrobial resistance. J. Dairy Sci., 101: 2415–2422.
]Search in Google Scholar