<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Rosacea is a chronic inflammatory skin disease characterised by transient or persistent erythema, telangiectasia, papules, and pustules that predominantly involve central regions of the face. Recent studies have shown a possible clinical association between rosacea and cardiovascular diseases (CVDs). Rosacea and atherosclerosis are both known to have alterations in the innate immune system, enhanced oxidative and endoplasmic reticulum stress. The aim of this review is to delve deep into the pathogenesis of rosacea and atherosclerosis to uncover possible pathogenic overlaps between these chronic inflammatory diseases.</p></abstract>

Rosacea is a chronic inflammatory skin disease characterised by transient or persistent erythema, telangiectasia, papules, and pustules that predominantly involve central regions of the face. Recent studies have shown a possible clinical association between rosacea and cardiovascular diseases (CVDs). Rosacea and atherosclerosis are both known to have alterations in the innate immune system, enhanced oxidative and endoplasmic reticulum stress. The aim of this review is to delve deep into the pathogenesis of rosacea and atherosclerosis to uncover possible pathogenic overlaps between these chronic inflammatory diseases.

Overlaps in the Pathogenesis of Rosacea and Atherosclerosis

Department of Infectology and Dermatology

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Overlaps in the Pathogenesis of Rosacea and Atherosclerosis"}

Rosacea is a chronic inflammatory skin disease characterised by transient or persistent erythema, telangiectasia, papules, and pustules that predominantly...

Overlaps in the Pathogenesis of Rosacea and Atherosclerosis

Published Online: Jun 21, 2018

Page range: 152 - 159

Received: Jul 11, 2017

Accepted: Jan 15, 2018

DOI: https://doi.org/10.2478/prolas-2018-0006

Keywords
rosacea, atherosclerosis, Toll-like receptor 2, LL-37, endoplasmic reticulum stress, oxidative stress

© 2018 Aleksejs Zavorins et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Overlaps in the Pathogenesis of Rosacea and Atherosclerosis

Published Online: Jun 21, 2018

Page range: 152 - 159

Received: Jul 11, 2017

Accepted: Jan 15, 2018

DOI: https://doi.org/10.2478/prolas-2018-0006

Keywordsrosacea, atherosclerosis, Toll-like receptor 2, LL-37, endoplasmic reticulum stress, oxidative stress

© 2018 Aleksejs Zavorins et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
rosacea, atherosclerosis, Toll-like receptor 2, LL-37, endoplasmic reticulum stress, oxidative stress