Serum microRNA-34a is potential biomarker for inflammation in nonalcoholic fatty liver disease
, , , , , and | Jan 31, 2017
About this article
Article Category: Brief communication (Original)
Published Online: Jan 31, 2017
Page range: 163 - 171
DOI: https://doi.org/10.5372/1905-7415.1002.478
Keywords
© 2016 Puth Muangpaisarn, Kanisa Jampoka, Sunchai Payungporn, Naruemon Wisedopas, Chalermrat Bunchorntavakul, Pisit Tangkijvanich, Sombat Treeprasertsuk
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
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Baseline demographic and biochemical findings from patients with NAFLD
| Characteristics, mean (SD) and number (%) | NAFLD patients (n = 50) |
|---|---|
| Age (year) | 46.0 (13.7) |
| Female patients (%) | 26 (52) |
| Weight (kg) | 93.0 (43.6) |
| Height (m) | 161.8 (9.6) |
| Body Mass Index (BMI) (kg/m2) | 35.8 (15.8) |
| Normal (BMI <23.0 kg/m2) | 3 (6) |
| Overweight (BMI 23.0-24.9 kg/m2) | 8 (16) |
| Obesity grade 1 (BMI 25.0-29.9 kg/m2) | 14 (28) |
| Obesity grade 2 (BMI 30.0-39.9 kg/m2) | 9 (18) |
| Morbid obesity (BMI >40 kg/m2) | 16 (32) |
| Metabolic syndrome | 38 (76) |
| Hypertension | 30 (60) |
| Hypercholesterolemia | 30 (60) |
| Diabetes mellitus and impaired fasting glucose | 27 (54) |
| Hypertriglyceridemia | 15 (30) |
| Albumin (g/dL) | 4.3 (0.4) |
| Total bilirubin (mg/dL) | 0.91 (0.39) |
| Aspartate aminotransferase (AST) (U/L) | 50 (32) |
| Alanine aminotransferase (ALT) (U/L) | 71 (45) |
| Alkaline phosphatase (ALP) (U/L) | 75 (22) |
| Fasting plasma glucose (mg/dL) | 114 (36) |
| Hemoglobin Alc (%) | 6.3 (1.2) |
| Triglyceride (mg/dL) | 143 (54) |
| Total cholesterol (mg/dL) | 197 (38) |
| High-density lipoprotein (HDL) (mg/dL) | 43 (10) |
| Low-density lipoprotein (LDL) (mg/dL) | 124 (35) |
Liver histological parameters of NAFLD patients
| Characteristics | NAFLD patients (n = 50) |
|---|---|
| NASH (%) | 33 (66) |
| Simple steatosis (%) | 17 (34) |
| 1 | 7 (14) |
| 2 | 5 (10) |
| 3 | 11 (22) |
| 4 | 15 (30) |
| 5 | 9 (18) |
| 6 | 3 (6) |
| FO | 19 (38) |
| Fl | 20 (40) |
| F2 | 5 (10) |
| F3 | 6 (12) |
| 1 (5-33%) | 24 (48) |
| 2 (34-66%) | 18 (36) |
| 3 (>66%) | 8 (16) |
| 0 (none) | 14 (28) |
| 1 (<2 foci/20 fields) | 27 (54) |
| 2 (2-4 foci/20 fields) | 9 (18) |
| 3 (>4 foci/20 fields) | 0 |
| 0 (none) | 16 (32) |
| 1 (few) | 24 (48) |
| 2 (many) | 10 (20) |