An Experimental Analytical and In Vitro Approach to Bridge Between Different Heated Tobacco Product Variants
, , , , , , et | 16 avr. 2022
À propos de cet article
Article Category: Short Communication
Publié en ligne: 16 avr. 2022
Pages: 1 - 9
Reçu: 16 nov. 2021
Accepté: 17 févr. 2022
DOI: https://doi.org/10.2478/cttr-2022-0001
Mots clés
© 2022 Tomasz Jaunky et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Figure 1
Figure 2
Test products and puffing regime.
| Product | Product code/puffing regime | Product descriptor | Variant | Blend (top flavour) | Product change from “Base” | Change classification |
|---|---|---|---|---|---|---|
| Reference cigarette | 1R6F / HCI |
Combustible reference | N/A | US Blend | N/A | N/A |
| Commercial comparator | THS 2.2_R / HCI |
THP_benchmark | THS2.2 | Tobacco (Regular) | N/A | N/A |
| Base | THP1.0_BT / HCIm |
THP_base | THP1.0 | Tobacco (Blended) | N/A | N/A |
| Variant 1 | THP1.1_RT / HCIm |
THP_1 | THP1.1 | Tobacco (Rich) | Change in tobacco flavour and increased nicotine | Minor |
| Variant 2 | THP1.1_C / HCIm |
THP_2 | THP1.1 | Citrus | Change in device aesthetics and top flavour | Minor |
| Variant 3 | THP1.1_S / HCIm |
THP_3 | THP1.1 | Smooth | Change in device aesthetics and top flavour | Minor |
| Variant 4 | THP1.1_F / HCIm |
THP_4 | THP1.1 | Fresh | Change in device aesthetics and top flavour | Minor |
| Variant 5 | THP1.1_RTF / HCIm |
THP_5 | THP1.1 | Tobacco (Rich) | Change in device aesthetics, top flavour and foil wrap | Major |
Comparison of analyte emissions among products1.
| Analyte | Units | 1R6F |
THP_benchmark |
THP_base | THP variant | ||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |||||
| Acetaldehyde | μg/consumable | 1859 (169) | 219 (31) | 122.6 (5.55) | 128.6 (7.89) | 131.8 (6.49) | 126.6 (12.62) | 123.6 (6.19) | 83.41 (3.95) |
| Acrolein | μg/consumable | 148 (22) | 11.3 (24) | 1.69 (0.13) | 1.70 (0.19) | 2.10 (0.21) | 1.99 (0.23) | 1.75 (0.15) | 1.24 (0.08) |
| Benzene | μg/consumable | 76 (5.8) | 0.649 (0.074) | 0.06 (0.02) | 0.09 (0.03) | 0.06 (0.02) | 0.04 (0.01) | 0.07 (0.03) | 0.06 (0.02) |
| Benzo[a]pyrene | ng/consumable | 11.4 (1.7) | NQ | 0.45 (0.15) | 0.31 (0.06) | 0.53 (0.06) | 0.43 (0.05) | 0.40 (0.05) | NQ |
| 1,3-Butadiene | μg/consumable | 114 (4) | 0.294 (0.042) | BDL | BDL | BDL | BDL | BDL | BDL |
| Formaldehyde | μg/consumable | 68.4 (3.9) | 5.53 (0.69) | 2.73 (0.96) | 2.38 (0.48) | 2.81 (1.56) | 2.65 (1.11) | 2.77 (1.22) | 1.51 (0.28) |
| NNK | ng/consumable | 208 (7) | 6.7 (0.6) | 7.46 (0.54) | 5.08 (0.63) | 10.01 (0.76) | 5.63 (1.18) | 6.46 (1.16) | 6.27 (0.84) |
| NNN | ng/consumable | 191 (8) | 17.2 (1.25) | 24.4 (1.96) | 16.5 (1.5) | 26.92 (1.72) | 0.04 (0.01) | 22.30 (3.16) | 13.31 (1.45) |
| CO | mg/consumable | 29.4 (0.6) | 0.532 (0.068) | BDL | BDL | BDL | BDL | BDL | BDL |
| Glycerol | mg/consumable | 1.36 (0.05) | 4.63 (0.83) | 2.12 (0.24) | 1.94 (0.35) | 2.81 (0.49) | 2.25 (0.37) | 2.38 (0.26) | 3.95 (0.29) |
| TPM | mg/consumable | 45.5 (2.2) | 10.3 (0.9) | 26.16 (1.49) | 27.12 (0.42) | 27.66 (1.25) | 26.34 (1.29) | 25.74 (1.84) | 26.11 (1.07) |
| Nicotine | mg/consumable | 2.0 (0.08) | 1.32 (0.16) | 0.38 (0.03) | 0.38 (0.04) | 0.46 (0.03) | 0.38 (0.03) | 0.38 (0.02) | 0.79 (0.02) |
| TAY | mg/consumable | 80.53 | 17.02 | 28.79 | 29.57 | 31.07 | 29.10 | 28.63 | 30.94 |
| TAY | mg/puff | 10.07 | 2.13 | 3.60 | 3.70 | 3.88 | 3.64 | 3.58 | 3.87 |
| TAY |
mg | 32.1 | 181.05 | 306 | 314.5 | 329.8 | 309.4 | 304.3 | 329 |
| % reduction relative to (1R6F) | % | N/A | 93.24 | 95.41 | 96.36 | 94.82 | 97.35 | 95.68 | 97.07 |