<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Green tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed information about the effect of a standard green tea extract (Polyphenon, P), at different doses, on antioxidant enzymes and oxidative stress markers in murine blood, liver, small and large intestine. In all doses, P improved the oxidative stress status via an increased content of plasmatic SH-groups (by 21-67 %). Regarding antioxidant enzymes in tissues, the low dose of P had the best positive effect as it elevated the activity of NADPH quinone reductase in liver and small intestine, thioredoxin reductase in small intestine and hepatic superoxide dismutase. Based on these facts, consumption of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione reductase and superoxide dismutase</p></abstract>

Green tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed information about the effect of a standard green tea extract (Polyphenon, P), at different doses, on antioxidant enzymes and oxidative stress markers in murine blood, liver, small and large intestine. In all doses, P improved the oxidative stress status via an increased content of plasmatic SH-groups (by 21-67 %). Regarding antioxidant enzymes in tissues, the low dose of P had the best positive effect as it elevated the activity of NADPH quinone reductase in liver and small intestine, thioredoxin reductase in small intestine and hepatic superoxide dismutase. Based on these facts, consumption of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione reductase and superoxide dismutase

Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo

Faculty of Pharmacy Charles University in Prague CZ-500 05 Hradec Králové Czech Republic

Faculty of Medicine and Dentistry Palacký University CZ-775 15 Olomouc Czech Republic

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Green tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed...

Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo

Published Online: Mar 11, 2015

Page range: 65 - 73

Received: Oct 15, 2014

DOI: https://doi.org/10.1515/acph-2015-0007

Keywords
green tea extract, dietary supplement, flavonoids, green tea catechins, antioxidant enzymes

© by Iva Boušová

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo

Published Online: Mar 11, 2015

Page range: 65 - 73

Received: Oct 15, 2014

DOI: https://doi.org/10.1515/acph-2015-0007

Keywordsgreen tea extract, dietary supplement, flavonoids, green tea catechins, antioxidant enzymes

© by Iva Boušová

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
green tea extract, dietary supplement, flavonoids, green tea catechins, antioxidant enzymes