<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Carboxylato-type transition metal complexes with agaric acid, a bioactive natural compound derived from citric acid, were prepared, and tested <italic>in vitro</italic> for their antimicrobial activity and cytotoxicity. The products as well as agaric acid itself are amphiphilic compounds containing a hydrophilic head (citric acid moiety) and a hydrophobic tail (non-polar alkyl chain). The putative composition of the carboxylates was assigned on grounds of elemental analysis, infrared (IR) and high-resolution mass spectra (HR-MS), as well as in analogy with known complexes containing the citrate moiety. The metal carboxylates showed interesting activity in several microbial strains, especially against <italic>S. aureus</italic> (vanadium complex; MIC = 0.05 mg/ml). They were also tested for their cytotoxic activity in hepatocytes, the highest activity having been found in the copper(II) and manganese(II) complexes. Further research based on these preliminary results is needed in order to evaluate the influence of parameters like stability of the metal complexes in solution on the bioactivity of the complexes.</p>
</abstract>

Carboxylato-type transition metal complexes with agaric acid, a bioactive natural compound derived from citric acid, were prepared, and tested in vitro for their antimicrobial activity and cytotoxicity. The products as well as agaric acid itself are amphiphilic compounds containing a hydrophilic head (citric acid moiety) and a hydrophobic tail (non-polar alkyl chain). The putative composition of the carboxylates was assigned on grounds of elemental analysis, infrared (IR) and high-resolution mass spectra (HR-MS), as well as in analogy with known complexes containing the citrate moiety. The metal carboxylates showed interesting activity in several microbial strains, especially against S. aureus (vanadium complex; MIC = 0.05 mg/ml). They were also tested for their cytotoxic activity in hepatocytes, the highest activity having been found in the copper(II) and manganese(II) complexes. Further research based on these preliminary results is needed in order to evaluate the influence of parameters like stability of the metal complexes in solution on the bioactivity of the complexes.

Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid

Department of Chemical Theory of Drugs, Faculty of Pharmacy

Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Carboxylato-type transition metal complexes with agaric acid, a bioactive natural compound derived from citric acid, were prepared, and tested in vitro for...

Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid

Article Category: Original Paper

Published Online: Jul 25, 2021

Page range: 46 - 53

Received: Nov 13, 2020

Accepted: Mar 01, 2021

DOI: https://doi.org/10.2478/afpuc-2020-0018

Keywords
Bioinorganic chemistry, metallodrugs, agaric acid, anticancer, antimicrobial, amphiphilic compounds

© 2021 L. Habala et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid

Article Category: Original Paper

Published Online: Jul 25, 2021

Page range: 46 - 53

Received: Nov 13, 2020

Accepted: Mar 01, 2021

DOI: https://doi.org/10.2478/afpuc-2020-0018

KeywordsBioinorganic chemistry, metallodrugs, agaric acid, anticancer, antimicrobial, amphiphilic compounds

© 2021 L. Habala et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Bioinorganic chemistry, metallodrugs, agaric acid, anticancer, antimicrobial, amphiphilic compounds