<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec>
<h3>Background</h3>
<p>Dysregulation the immune system is characteristic of the severe stages of COVID-19 disease; therefore, the study aimed to highlight the defective immune regulation patients with COVID-19 pneumonia without chronic diseases.</p>
</sec>
<sec>
<h3>Methods</h3>
<p>The study included 180 individuals, 60 as a control group, and 120 patients with COVID-19, including 67 males and 53 females, whose ages ranged from 27 to 70 years, at Imam Al-Hussein Teaching Hospital in Thi-Qar Province, South of Iraq. The CXCL 10 and IL-10 were evaluated by enzyme-linked immunosorbent assay (ELISA).</p>
</sec>
<sec>
<h3>Results</h3>
<p>The current study recorded that CXCL 10 was significantly increased &lt; 0.001 in patients compared to controls, while the IL-10 was decreased significantly in patients, within disease severity the CXCL 10 increased with progress of disease, and IL-10 increased in sever patients, according to BMI the CXCL 10 decrease in obese patients than over and normal weight, while IL-10 increased in normal weight patients.</p>
</sec>
<sec>
<h3>Conclusion</h3>
<p>This study investigated the CXCL 10 was highly elevated in COVID-19 patients than control group, also noted the CXCL 10 increased with disease progress, therefor consider a good marker for poor outcome, furthermore the obese patients are more likely to have severe outcomes than others, so BMI is considered a risk factor for patients.</p>
</sec>
</abstract>

Background
Dysregulation the immune system is characteristic of the severe stages of COVID-19 disease; therefore, the study aimed to highlight the defective immune regulation patients with COVID-19 pneumonia without chronic diseases.


Methods
The study included 180 individuals, 60 as a control group, and 120 patients with COVID-19, including 67 males and 53 females, whose ages ranged from 27 to 70 years, at Imam Al-Hussein Teaching Hospital in Thi-Qar Province, South of Iraq. The CXCL 10 and IL-10 were evaluated by enzyme-linked immunosorbent assay (ELISA).


Results
The current study recorded that CXCL 10 was significantly increased < 0.001 in patients compared to controls, while the IL-10 was decreased significantly in patients, within disease severity the CXCL 10 increased with progress of disease, and IL-10 increased in sever patients, according to BMI the CXCL 10 decrease in obese patients than over and normal weight, while IL-10 increased in normal weight patients.


Conclusion
This study investigated the CXCL 10 was highly elevated in COVID-19 patients than control group, also noted the CXCL 10 increased with disease progress, therefor consider a good marker for poor outcome, furthermore the obese patients are more likely to have severe outcomes than others, so BMI is considered a risk factor for patients.

Evaluation of CXCL 10 and IL-10 in COVID-19 pneumonia

Pneumologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Evaluarea CXCL 10 și IL-10 în pneumonia COVID-19

Background
Dysregulation the immune system is characteristic of the severe stages of COVID-19 disease; therefore, the study aimed to highlight the defective...

Evaluation of CXCL 10 and IL-10 in COVID-19 pneumonia

Article Category: Original Paper

Published Online: May 02, 2024

Page range: 175 - 180

DOI: https://doi.org/10.2478/pneum-2023-0043

Keywords
CXCL 10, IL-10, COVID-19, Severity of Disease, Cytokine Storm

© 2022 Hayder Fadhil Okab et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Evaluation of CXCL 10 and IL-10 in COVID-19 pneumonia

Article Category: Original Paper

Published Online: May 02, 2024

Page range: 175 - 180

DOI: https://doi.org/10.2478/pneum-2023-0043

KeywordsCXCL 10, IL-10, COVID-19, Severity of Disease, Cytokine Storm

© 2022 Hayder Fadhil Okab et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
CXCL 10, IL-10, COVID-19, Severity of Disease, Cytokine Storm