Article Category: Original Paper
Published Online: May 02, 2024
Page range: 175 - 180
DOI: https://doi.org/10.2478/pneum-2023-0043
Keywords
© 2022 Hayder Fadhil Okab et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Background
Dysregulation the immune system is characteristic of the severe stages of COVID-19 disease; therefore, the study aimed to highlight the defective immune regulation patients with COVID-19 pneumonia without chronic diseases.
Methods
The study included 180 individuals, 60 as a control group, and 120 patients with COVID-19, including 67 males and 53 females, whose ages ranged from 27 to 70 years, at Imam Al-Hussein Teaching Hospital in Thi-Qar Province, South of Iraq. The CXCL 10 and IL-10 were evaluated by enzyme-linked immunosorbent assay (ELISA).
Results
The current study recorded that CXCL 10 was significantly increased < 0.001 in patients compared to controls, while the IL-10 was decreased significantly in patients, within disease severity the CXCL 10 increased with progress of disease, and IL-10 increased in sever patients, according to BMI the CXCL 10 decrease in obese patients than over and normal weight, while IL-10 increased in normal weight patients.
Conclusion
This study investigated the CXCL 10 was highly elevated in COVID-19 patients than control group, also noted the CXCL 10 increased with disease progress, therefor consider a good marker for poor outcome, furthermore the obese patients are more likely to have severe outcomes than others, so BMI is considered a risk factor for patients.